Filtyp
The underlying question in localization is, where am I? In this thesis a purely image based approach is proposed to solve this problem. In order to create a complete image based system, there are many subproblems that have to be addressed. The localization problem can also be solved in other ways, for example, with a GPS. Two advantages with using images compared to GPS are that no open sky is nee
This thesis describes a number of coherent processes, such as quantum information processing, superradiance and electromagnetically induced transparency, which have been experimentally implemented using rare-earth-ion-doped crystals. The rare-earths are a class of elements that have in common, an atomic structure that allows for very long lifetimes as well as coherence times, both on optical trans
Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. The specificity of the vector is however important to avoid potential off-target effects
Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xen
Familial hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, transmitted in an autosomal dominant fashion, i.e. 50% risk for transmission of the disease-causing mutation to each child of the affected family. Previous studies reveal a high risk for HCM related cardiac events including sudden cardiac death (SCD) during childhood, with a peak incidence of up to 10% during th
Transplantation of vital organs is today a widely used treatment when failure of the organ is a fact. To prevent rejection immunosuppresive treatment must be maintained lifelong, unless transplantation is perfomed between identical twins. Many immunosuppresive agents introduced in clinical practice have been benificial in improving graft survival rates, but adverse effects remains a huge problem t
Abstract The efficiency of different leachate treatment methods for the removal of refractory organic compounds and ammonium-nitrogen was investigated. The methods evaluated were nitrification, denitrification, adsorption onto activated carbon, precipitation by ferric chloride or aluminum sulphate and oxidation by ozone or Fenton´s reagent. Furthermore, analyses were performed on leachates from mu
Two non-thermal regimens of light interaction with biological tissue, that are in a natural way connected, are discussed in the present thesis. These are photodynamic therapy (PDT) for the treatment of malignant tumours and laser-induced fluorescence (LIF) for tissue characterization. In PDT, a photochemical reaction is induced by non-ionizing electromagnetic irradiation in tissue where photosens
In my research, I have explored various aspects of acetals and their reactivity. Acetals have a central role in carbohydrate chemistry as an inherent functionality and as versatile protecting groups. The first part of the thesis summarizes results on regioselective reductive openings of benzylidene acetals. We thus used deuterium substituted benzylidene acetals and boranes, to investigate stereose
The overall aim of this composite thesis, consisting of five articles, is to develop concepts for furthering the understanding of small business managers´ handling of finance. The main contribution is the development of a conceptual understanding of so-called financial bootstrapping behavior in small businesses (referring to the use of methods for minimizing and/or eliminating the need for financi
Degradation of mRNA is a controlled process which is as important for gene regulation as the synthesis of mRNA. This thesis focuses on mechanisms of mRNA stability and degradation in Bacillus subtilis, the model of Gram-positive bacteria. The aprE mRNA, encoding an exported protease named subtilisin, is extremely stable with a half-life of more than 25 minutes. Average mRNA half-lives in B. subtil
The neutrophil store its effector proteins in several distinct types of cytoplasmic granules, developed sequentially during cell maturation. The different subtypes of granules have unique protein content and functional characteristics. The formation of each granule subtype coincides with the biosynthesis of its content. Granule proteins synthesised during the formation of a granule subtype are thu
Falls and fractures in older people are a common and increasing health problem which causes physical, social and psychological problems for the individual and is costly to society. The aims of this thesis were to investigate accidental falls of patients aged 65 - 74 who attended an orthopedic emergency ward, to investigate reliability of the modified figure of eight (MFE) and compare it with other
The topic of this dissertation is the work of the poet Bruno K. Öijer (b. 1951). My thesis is, that a recognition of how he has assumed the outsider position is vital for an understanding of his work, and that it also may contribute to an explanation of his particular importance in the cultural arena of the early 70s. The thesis is structured in four parts. Part one deals with the concept “outside
Two polymers, alginate and Eudragit S-100 were used as reversibly soluble-insoluble ligand carriers for the selective isolation of enzymes and lectins respectively. These two polymers have the inherent property of being precipitated under well defined conditions. Alginate was made insoluble by the addition of Ca2+ ions, and Eudragit S-100 by a pH shift. The polymers were modified with affinity lig
Infectious pancreatic necrosis virus (IPNV) is a Birnavirus that infects salmonid fish. The infection is usually mortal for fish under six months of age, while older fish become carriers, usually without any signs of infection, and will spread the virus to other susceptible fish and to their offspring. IPNV is an icosahedral, naked virion and the genome consists of two segments of double-stranded
Organizational creativity and psychological well-being. Present day organizations in a globalized society are experiencing external challenges and changes more than ever before and in order to adapt and react to these changes creativity and innovation are seen as some of the most important means. The standpoint in this thesis is that all employees have creative potential, and how the creative pote
Interactions of proteins with other proteins, with polymers and with surfaces are of great practical importance within for instance protein purification, drug delivery, and food technology. The aim of this work is to increase the understanding of protein-protein, protein-polyelectrolyte, and protein-surface interactions, particularly concerning the role of electrostatic interactions in these syste
This thesis in industrial design concerns the challenges and possibilities in meeting demographic shifts and the presumed expectations of today’s and tomorrow’s older generations. The background is the lack of furniture that responds to the demands of older consumers and the lack of knowledge about relationships between people and furniture in their home environments and in various forms of elderl
Helicobacter pylori is a gastric pathogen colonising the gastric mucus layer and epithelium of gastric tissue and is associated with chronic type B gastritis and peptic ulcer disease. The attachment of H. pylori to gastric epithelial cells involves several structures recognised by specific bacterial surface proteins. Since colonisation is an initial and critical step in the development of a chroni
