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PurposeThis paper aims to examine how governance structures and actor dynamics shape knowledge integration in digital place innovation. Collaborative governance research emphasizes coordination and consensus-building, but less is known about how municipalities and private firms integrate heterogeneous knowledge systems when co-creating digital solutions for urban centers. Conceptualizing digital pPurposeThis paper aims to examine how governance structures and actor dynamics shape knowledge integration in digital place innovation. Collaborative governance research emphasizes coordination and consensus-building, but less is known about how municipalities and private firms integrate heterogeneous knowledge systems when co-creating digital solutions for urban centers. Conceptualizing digital p

This study investigates the stock of words for PROPERTY IN GENERAL with the subcategories MOVABLE and IMMOVABLE PROPERTY in the regional medieval Scandinavian laws and makes a linguistic-geographical analysis of these words with the aim of establishing a relative term chronology. A crude analysis shows that fé/fæ for PROPERTY IN GENERAL and land for IMMOVABLE PROPERTY were the oldest

Endothelin-1 (ET-1) is an extremely potent smooth muscle spasmogen well known from the vascular system but also active within the airways. The importance of its proinflammatory and co-mitogenic properties has become increasingly evident, the endothelin system also having been shown to mimic the signal features of asthma, COPD and other pulmonary diseases. The present thesis concerns the role of th

Type 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. In addition to well-known hallmarks of the disease, such as defective insulin secretion, insulin resistance and perturbed glucagon secretion, we aimed to find a possible role for CLOCK genes in the pathogenesis of

The susceptibility to mould growth varies between building materials. The factors that most affect mould growth, the relative humidity (RH) and temperature also vary in different parts of buildings. One way of preventing the growth of mould in buildings is therefore to choose building materials that can withstand the expected conditions. It is thus crucial that data are available to allow the corr

Background: Acute ischemia of the lower limb is a vascular emergency associated with amputation and death. Patients suffering from acute limb ischemia are usually elderly, and multiple comorbidities are often present. Intra-arterial thrombolysis is, perhaps, the most important minimal-invasive treatment option available today. Although uncontrolled hemorrhage is a dreaded complication, it is consi

Antineoplastic drugs are commonly used in the medical treatment of cancer and some other diseases. Workplaces e.g. hospital pharmacies and wards where antineoplastic drugs are used are contaminated with these drugs and health care workers are therefore at risk of getting occupationally exposed. Many antineoplastic drugs are classified as carcinogenic and teratogenic to humans. Cyclophosphamide (CP

Brain damage from ischemia-reperfusion and hypoglycemia are major causes of morbidity and mortality. Therapeutic strategies include hypothermia, glutamate-receptor blockade, immunosuppression and lately treatment aiming at preserving mitochondrial integrity and function. Mitochondria are the main producers of cellular energy but mitochondria also participate in cell signaling and take an active pa

Cytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. Roquinimex, the lead compound, was found to be metabolised by CYPs to hydroxylated and demethylated metabolites. A similar metabolite patter

The aim of this dissertation is to explore the possibilities of an adequate understanding of time by discussing concepts of time (and eternity) as they appear in church texts, theological thinking, and natural science from the Newtonian era to modern physics. Relationality, dynamics, multiplicity, and narrativity are suggested as indispensable dimensions of such an understanding. Inspired by P. R

This thesis takes its starting point in the large spread and rise in obesity prevalence that have been observed around the world, making obesity an increasing public health concern. The thesis consists of an introductory chapter, which justifies the study of obesity from economic perspectives and puts the subsequent studies in context, and four studies that address obesity from different economic