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Sesquiterpene synthases in Artemisia annua: Cloning, Expression, and Characterisation of the Recombinant Enzymes

Plants produce a multitude of different compounds that may have biotic effects. Artemisia annua, produces a compound used as a drug against multi-drug-resistant strains of Plasmodium falciparum, the parasite causing malaria. The compound, artemisinin, is a sesquiterpene and is an essential component for the production of artemisinin drugs against malaria. In a first critical step of the biosynthes