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Contributor to climate change, cities are the major responsible for a great amount of natural resource consumption and global waste production as a consequence of the ”take, make, dispose" aspects of our linear economic model. In face of this issue, Circular Economy (CE) is a new concept that seeks to decouple economic growth from the consumption of finite resources by shifting the linear eco
The Basel III regulatory framework was created in direct response to the financial crisis that occurred in 2007-2008. The regulatory framework in place during and before the crisis, Basel II, had not done enough to prevent the crisis. This prompted a revision and expansion of the regulations. The regulators created a new framework, which was initiated in January of 2013 and is expected to be fully
Syftet med den här uppsatsen är att argumentera för en individuell föräldraförsäkring. Den svenska föräldraförsäkringen studeras utifrån ett rättighetsperspektiv, något som tidigare har saknats. Föräldraförsäkringen är idag en grupprättighet och stor del av min teori har därför kretsat kring grupprättigheter och individuella rättigheter. I analysen av förarbetena till föräldraförsäkringen blir det
Problemfomulering: Ystad, som är beläget längs Skånes sydkust, har länge varit utsatt för kusterosion. När det blåser över Östersjön genereras vågor som orsakar uppspolning och direkt erosion av klitterna på stranden. Ett av de mest utsatta områdena är Ystads Sandskog, beläget öster om Ystads centrum. Här karakteriseras strandprofilen av en relativt kort strand med klitter som skyddar den låglänta
The employer’s right to rule is always a burning topic and many employers are currently not as familiar with the subject as they perhaps should be. High demands are placed on the employer in an employment relationship with employees, who also apply to employees. At the same time, the employer has been given, through the employer’s right to rule, the right to freely manage and allocate work in the
The overall aim of this composite thesis, consisting of five articles, is to develop concepts for furthering the understanding of small business managers´ handling of finance. The main contribution is the development of a conceptual understanding of so-called financial bootstrapping behavior in small businesses (referring to the use of methods for minimizing and/or eliminating the need for financi
Degradation of mRNA is a controlled process which is as important for gene regulation as the synthesis of mRNA. This thesis focuses on mechanisms of mRNA stability and degradation in Bacillus subtilis, the model of Gram-positive bacteria. The aprE mRNA, encoding an exported protease named subtilisin, is extremely stable with a half-life of more than 25 minutes. Average mRNA half-lives in B. subtil
The neutrophil store its effector proteins in several distinct types of cytoplasmic granules, developed sequentially during cell maturation. The different subtypes of granules have unique protein content and functional characteristics. The formation of each granule subtype coincides with the biosynthesis of its content. Granule proteins synthesised during the formation of a granule subtype are thu
Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. The specificity of the vector is however important to avoid potential off-target effects
Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xen
Familial hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, transmitted in an autosomal dominant fashion, i.e. 50% risk for transmission of the disease-causing mutation to each child of the affected family. Previous studies reveal a high risk for HCM related cardiac events including sudden cardiac death (SCD) during childhood, with a peak incidence of up to 10% during th
Transplantation of vital organs is today a widely used treatment when failure of the organ is a fact. To prevent rejection immunosuppresive treatment must be maintained lifelong, unless transplantation is perfomed between identical twins. Many immunosuppresive agents introduced in clinical practice have been benificial in improving graft survival rates, but adverse effects remains a huge problem t
Sepsis is a systemic inflammatory response syndrome to a localized or systemic infection that leads to the over production of proinflammatory cytokines and the ultimate failure of multiple organ systems. However, little is known about the potential role of Rac1 in controlling sepsis-induced intracellular signaling pathways. We hypothesized that Rac1 might be involved in sepsis mediated signaling p
Three different methods for Reynolds-averaged Navier-Stokes computational fluid dynamics modeling of non-premixed ignition and combustion using tabulated chemistry have been developed. All methods make use of flamelet libraries, where the flamelet auto-ignition process is parameterized using a progress variable. The progress variable parameterization of the auto-ignition chemistry allows for using
Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. Because of these features, HSCs are also the basis for bone marrow transplantation regimens for tr
This thesis has two main objectives related to trading foreign currencies. First, it is investigated how the customer order ow of Nordea is related to currency price changes. Second, the goal is to nd a new way of grouping customers that can give additional insights in the trading behaviour of dierent customers. The study uses order ow data which consists of spot and forward transactions made in
