Protein affinity reagents (PARs), most commonly antibodies, are essential reagents for protein characterization in basic research, biotechnology, and diagnostics as well as the fastest growing class of therapeutics. Large numbers of PARs are available commercially; however, their quality is often uncertain. In addition, currently available PARs cover only a fraction of the human proteome, and thei

With the advent of multimodality therapy, the overall five-year survival rate from childhood cancer has improved considerably now exceeding 80% in developed European countries. This growing cohort of survivors, with many years of life ahead of them, has raised the necessity for knowledge concerning the risks of adverse long-term sequelae of the life-saving treatments in order to provide optimal sc

Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are

We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression of mitochondrial or cytosolic FH but not by deletion of Hif1α or Nrf2. Progressive hyperglycem

Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. Here, we conducted a genome-wide association study (GWAS) involving 1,554 cases/1,973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from the EPITHYR consortium. Our results confirmed the association with the know

Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern

The activated B cell (ABC-like) subtype of diffuse large B cell lymphoma (DLBCL) is characterized by chronic activation of signaling initiated by immunoglobulin m (IgM). By analyzing the DNA copy number profiles of 1000 DLBCL tumors, we identified gains of 18q21.2 as the most frequent genetic alteration in ABC-like DLBCL. Using integrative analysis of matched gene expression profiling data, we fou

Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory mechanism is impaired in diabetes. Here we show in mice that therapeutic concentrations of insulin inhibit g

Ferritin heavy chain (FTH1) is a 21-kDa subunit of the ferritin complex, known for its role in iron metabolism, and which has recently been identified as a favorable prognostic protein for triple negative breast cancer (TNBC) patients. Currently, it is not well understood how FTH1 contributes to an anti-tumor response. Here, we explored whether expression and cellular compartmentalization of FTH1

REPORT ON PROGRESS 2015 cOPENhaGEN buSiNESS SchOOl pr in ci pl es fo r re sp on si bl e m an ag em en t e du ca ti on 2 This is the Copenhagen Business School’s (CBS) third Sharing Information on Pro- gress (SIP) report on the United Nations (UN) Principles for Responsible Manage- ment Education (PRME). It summarises CBS’ achievements and our ambition to become a leading business school in respons

https://www.ses.lu.se/sites/ses.lu.se/files/cbssustainability_report2015.pdf - 2025-02-01

We assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of steroid hormones and insulin-like growth factor 1, and risk of breast cancer in situ (BCIS), with the aim of determining whether any of these were disease specific. This was carried out using 1,062 BCIS cases and 10,126 controls as well as 6,113 invasive breast cancer c

Background Hexavalent chromium (Cr(VI)) is a carcinogen. Exposure to Cr(VI) may occur in different industrial processes such as chrome plating and stainless steel welding. The aim of this study was to assess occupational exposure to Cr(VI) in Denmark. Methods This cross-sectional study included 28 workers and 8 apprentices with potential Cr(VI) exposure and 24 within company controls, all recruite

Background: Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease. Methods: We did a multicentre, open-label, randomised crossover trial with blinded endpoint assessment at five specialist centres in Europe. We included participants aged

Background. Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. Methods. We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD du

AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection aga

Tillämpning av skyltmanual LU Byggnad Lunds universitet Tillämpning av skyltmanual LU Byggnad 2 • skyltmanual · Lunds universitet »mörkblå« PANTONE 280 COATED »brons« PANTONE 1395 COATED Frutiger 45 Light (endast inomhus) Frutiger 46 Light italic (endast inomhus) Frutiger 55 Roman Frutiger 56 ltalic Frutiger 65 Bold beskuret universitetssigill Universitetshuset Un1vers1tetshuset 2 · skyltmanual ·

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2022-01/20171101-skyltmanual-lu-tillg.pdf - 2025-02-01

Professor Contact details Email: dan [dot] hammarlund [at] geol [dot] lu [dot] se Phone: +46 46 222 79 85 Mobile: +46 73 062 85 67Organisation Quaternary Sciences Room number: 477 Service point: 16 WebpageDan Hammarlunds profile in Lund University research portalOther affiliations Researcher MERGE: ModElling the Regional and Global Earth system Principal investigator BECC: Biodiversity and Ecosyst

https://www.geology.lu.se/dan-hammarlund - 2025-02-02

Social environmental scientist Contact details Email: johanna [dot] alkan_olsson [at] cec [dot] lu [dot] se Phone: +46 46 222 17 93 Mobile: +46 72 741 79 90Organisation Centre for Environmental and Climate Science (CEC) Visiting address: Ekologihuset, Sölvegatan 37, Lund Room number: E237 Service point: 50 WebpageJohanna Alkan Olssons profile in Lund University research portalOther affiliations As

https://www.cec.lu.se/johanna-alkan-olsson - 2025-02-02

VETENSKAP OCH BEPRÖVAD ERFARENHET TANDVÅRD VETENSKAP OCH BEPRÖVAD ERFARENHET VID SBU | 1 2 | STEN ANTTILA & SUSANNA AXELSSON VETENSKAP OCH BEPRÖVAD ERFARENHET TANDVÅRD ISBN 978-91-983575-8-5 © VBE-programmet och författarna Grafisk form Johan Laserna Tryckt av Media-Tryck, Lunds universitet, Lund 2019 Förord 9 NILS-ERIC SAHLIN Vad är vetenskap och vad är beprövad erfarenhet? Och vad betyder eviden

https://www.vbe.lu.se/sites/vbe.lu.se/files/vbe_tandvard_webb.pdf - 2025-02-01