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BACKGROUND Nivolumab was associated with higher rates of objective response than chemotherapy in a phase 3 study involving patients with ipilimumab-refractory metastatic melanoma. The use of nivolumab in previously untreated patients with advanced melanoma has not been tested in a phase 3 controlled study. METHODS We randomly assigned 418 previously untreated patients who had metastatic melanoma w
Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat
The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the n
In recent years, it has become increasingly recognized that the traditional production-based methods for calculations of greenhouse gas emissions have shortcomings. This is justified by the fact that such inventories only include emissions that occur within a particular geographical area. As major emissions also arise as a result of imports of goods and services and from international travel, such
Stor blåklocka bättre pollinerad i staden än på landsbygden Världen över är människor indirekt beroende av pollinerande djur då de förser oss med mat, mediciner och råmaterial genom att hjälpa växters fortplantning. Inom denna djurgrupp dominerar insekter där bin och humlor är särskilt viktiga på nordliga breddgrader. Det finns dock en stor oro kring våra pollinerande insekter idag. Som ett resul
Extrema klimathändelser såsom torka, skyfall och extrema temperaturer förväntas bli mer frekventa som följd av klimatförändringar. Extrema klimathändelser kan potentiellt stressa och skada vegetation över stora områden och leda till förändring i kolcykel, vegetationsgrönhet, albedo samt ändrad artkomposition. Denna studie fokuserar på två typer av extrema klimathändelser; frystorkning orsakad av eWith climate change, the frequency in climate extremes such as drought, heavy rainfalls, and extreme temperatures is predicted to increase. These extremes can potentially stress and damage vegetation over large areas, leading to altered carbon cycle, vegetation greenness, albedo, and shifted species composition. This study focuses on two different types of extreme events; frost drought caused by w
Anemia because of insufficient production of and/or response to erythropoietin (Epo) is a major complication of chronic kidney disease and cancer. The mechanisms modulating the sensitivity of erythroblasts to Epo remain poorly understood. We show that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (Tf
Acute myeloid leukemia with t(6; 9)(p22; q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6; 9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6; 9)/DEKNUP214-rearranged myeloid leukemia; 54
Problem: Företag som är en del av en multinationell verksamhet kan råka ut för kriser som är en följd av en händelse som utspelat sig på långt geografiskt avstånd. Ett exempel på detta är energibolaget Enrons konkurs, som har kastat en skugga över hela revisionsvärlden. Enrons konkurs berodde bland annat på tveksamma bokföringsmetoder och till följd av detta har även deras revisorer ifrågasatts. R
In 2006, Professor Juliet Stumpf at the Lewis and Clark Law School in Portland, Oregon coined the term “crimmigration”. In doing so, she gave a name to a legal development that had evolved in the United States since the mid-1980s. The term is a concatenation of ”criminal” and ”immigration”; suitable considering the legal field describes and highlights the merger of criminal and immigration law. To
Den centrala frågan i denna framställning är huruvida det finns ett behov av förändring vad gäller livstidsstraffet i Sverige, och om frågan besvaras jakande, vad förändringen i så fall skulle bestå av. För att kunna besvara frågeställningen på ett tillfredställande sätt jämförs det svenska livstidsstraffet med de engelska och norska påföljdssystemen. Inledningsvis redogörs för olika bestraffningThe main point of this thesis is whether or not there is a need for modifications of the life sentence in Sweden, and should that be the case, how that modification is supposed to be constructed. To answer this in an adequate manner, the Swedish life sentence is going to be compared to the English and Norwegian equivalents. To start with, an account of different theories on penalization and princ
Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i
On 1 July 2018, Sweden amended its sexual offence legislation to strengthen the protection of individuals' sexual integrity and self-determination. The reform criminalized the performance of sexual acts with someone who does not participate voluntarily, regardless of violence, threats or exploitation of a particularly vulnerable situation. In addition, negligent rape was introduced as a new cr
Under de senaste åren har hållbarhetsfrågor fått en alltmer framträdande roll i samhällsdebatten. Det som tidigare till stor del reglerades genom så kallad soft law, såsom riktlinjer och rekommendationer, har i ökande utsträckning börjat omfattas av bindande reglering. Klimatförändringarna och andra globala utmaningar har bidragit till att både Förenta nationerna (FN) och Europeiska unionen (EU) hIn recent years, sustainability issues have become increasingly prominent in the public debate. What was previously largely regulated through soft law, such as guidelines and self-regulation, has increasingly become subject to binding regulation. The climate change and other global challenges have contributed to both the United Nations (UN) and the European Union (EU) developing international agre
New rules came into force in the Tenancy Act (Sw. hyreslagen) on 1 July 2024 to create safer residential areas. These rules aim to give landlords greater opportunities to evict tenants involved in criminal activity that creates insecurity for the other tenants. This paper investigates what these new rules mean, and whether there are reasons to extend them to also cover tenant owned apartments. To
Background: Neoadjuvant therapy is protective of postoperative pancreatic fistula in pancreatoduodenectomy. However, the effect of neoadjuvant therapy after left pancreatectomy remains unclear. The aim of this international multicenter study was to evaluate the impact of neoadjuvant therapy on short term outcomes after left pancreatectomy for pancreatic ductal adenocarcinoma. Methods: Patients und
Background Postoperative pancreatic fistula (POPF) is a major complication after left pancreatectomy. The current International Study Group of Pancreatic Surgery classification has limitations, including heterogeneity in morbidity and high interobserver variability. This study aimed to assess POPF-related morbidity after left pancreatectomy and propose a refined classification system. Methods Pati
Following regulatory approval of anti-amyloid beta (Aβ) therapies, a better characterization of patients receiving these treatments is needed to guide clinical management and inclusion in future trials. This Alzheimer's Association-convened workgroup proposes a terminology, treatment-related amyloid clearance (TRAC), to reflect alterations in disease pathophysiology based on biomarker evidence for
Språk- och litteraturcentrum Litteraturlista för KINM13 ”RÖDA LISTAN”: FÖRDJUPNING I KANSLISPRÅKLIG KINESISKA, 15 hp Fastställd av Lärarkollegium 5, 2014-03-31. Reviderad av styrelsen för Sektion 5 2021-11-24 --------------------------------------------------------------------------------------------------------------------------- 2021年3月26日外交部发言人华春莹主持例行记者会 (Utrikesministeriets talesperson Hua Chu
https://www.sol.lu.se/media/utbildning/dokument/kurser/KINM13/20232/KINM13_litteraturlista_23.docx - 2026-06-18
Språk- och litteraturcentrum Författarskolan Kurslitteratur för LUFM10 Litterär gestaltning – fördjupningskurs på avancerad nivå 1–30 hp, ht 2026 (Fastställd i Sektionsstyrelse 2, SOL-Centrum, 8 juni 2026) Delkurs 1: Teori, 5 hp Cixous, Hélène (1994), Three Steps on the Ladder of Writing, New York: Columbia University Press (162 s.) Artiklar och skönlitteratur kan tillkomma. (ca. 400 s.) Referens
https://www.sol.lu.se/media/utbildning/dokument/kurser/LUFM10/20262/LUFM10_ht_26.pdf - 2026-06-18
