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Background: The prevalence of autism in Denmark has been increasing, reaching 1.65% among 10-year-old children, and similar trends are seen elsewhere. Although there are several factors associated with autism, including genetic, environmental, and prenatal factors, the molecular etiology of autism is largely unknown. Here, we use untargeted metabolomics to characterize the neonatal metabolome from
Background: Understanding the relationship among changes in Clinical Dementia Rating (CDR), patient outcomes, and probability of progression is crucial for evaluating the long-term benefits of disease-modifying treatments. We examined associations among changes in Alzheimer’s disease (AD) stages and outcomes that are important to patients and their care partners including activities of daily livin
In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated the potential role of ALK mutations in neuroblastoma clonal evolution.
Within innate immune signaling pathways, Interleukin-1 receptor (IL-1R&)-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like receptors (TLR) and the IL-1R. Whereas human IRAK4-deficiency was shown to lead to severe immunodeficiency in response to pyogenic bacterial infection during childhood, little is known about the role of human IRAK2. We here identified a non-syno
The object of this study was to determine the association between tender point pain ratings, tender point counts and distress in people with fibromyalgia and to review the pharmacotherapy of fibromyalgia. Demographic, psychosocial, and health status information was collected from 316 health maintenance organization members with fibromyalgia. A manual tender point exam was conducted. Tender point c
Overcoming cellular growth restriction, including the evasion of cellular senescence, is a hallmark of cancer. We report that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor patient outcome. In mice, MMTV-PAK4 overexpression promotes spontaneous mammary cancer, while PAK4 gene depletion delays MMTV-PyMT driven tumors. Importantly, PAK4 prevents senescence-like gr
We present new data for the ∼3.0 Ga Maniitsoq Norite Belt of the Akia Terrane, West Greenland, with the aim of understanding its petrogenesis. The Maniitsoq Norite Belt is hosted in regional tonalite-trondhjemite-granodiorite (TTG) and dioritic orthogneisses, intruded by later sheets of TTG and granite pegmatites, and comprises two main rock types: plagioclase-rich “norites” and pyroxene-rich “mel
This paper reports and demonstrates a packetponder for access/metro node consolidation and aggregation using common-form-factor pluggables (CFFP), which can simplify edge network architectures.
Det relativt nya fenomenet reality-serier blir allt populärare och upptar en stor del av dagens tv-tablå. Fenomenet tillsammans med övrig massmedia har större inflytande och påverkan på samhället och oss människor än någonsin tidigare. Man diskuterar alkoholens roll i samhället, dess konsekvenser för relationer, hälsa o.s.v. Sedan TV kom har även alkoholens representation i TV kommit att bli en he
Abstract Title: IFRS 15 - Full or Modified Retrospective Application? A study of the standard’s effects and the factors behind companies’ choice of transition method. Seminar date: June 2nd, 2021 Course: FEKH69, Degree Project Undergraduate level, Business Administration, 15 University Credits Points (ECTS) Authors: Julia Baeza, Vendela Barth and Felicia Sonesson Advisor: Kristina Artsberg Key wor
Since July 1, 2013, there is no longer a sterilization requirement for transgender persons who want to transition. This paper critically examines the new legislation in the Parental Code, which entered into force on January 1, 2019 as a result of the abolished sterilization requirement. The new legislation applies to parenthood when one or both parents have changed their legal gender. Before the n
On the first of July, 2021, it became a crime in Sweden to allow children to witness crimes between relatives. The crime is called ”barnfridsbrott” and exists in Chapter 4, Section 3 in the Swedish Criminal Code. The criminalization of allowing children to witness crimes between relatives was met with a positive response from most of the consultation bodies. Although it was welcomed with open arms
As a result of the increased gang violence in Sweden, a crown witness system was introduced on July 22, 2022, which has been widely criticized. However, the legislator considered such regulation to be predominantly necessary. By introducing a new paragraph, ch. 29 § 5 a in the Swedish Criminal Code, the legislation can be described as an attempt to escape the culture of silence and initiate an eff
Fysiskt och psykiskt våld förekommer i många hem i Sverige. Allt för många barn växer upp med att få se, höra och uppleva detta våld. Under de senaste åren har forskning tydligt visat att barn som bevittnat våld inom familjen påverkas väldigt negativt. De känner ofta en känsla av maktlöshet, övergivenhet och skam. För att stärka barnets rättsliga ställning har det tidigare införts en straffskärpnPhysical and psychological violence exist in many homes in Sweden. Far too many children have grown up with witnessing, hearing and experience the violence. In recent years research has shown that children who witness violence within the family gets profoundly affected. They often feel a sense of powerlessness, abandonment, and shame. To strengthen the legal position of the child, a basis for aggr
In July 2024, the Inquiry on Sanctions, Recidivism, and Enforcement submit-ted its report, SOU 2024:48, which includes a proposal to introduce a preventively oriented, indefinite deprivation of liberty as a sanction, referred to as a security sentence. The purpose of the proposal is to enable the indefinite detention of an offender in particularly serious situations, where the sanction cannot be d
Konformitetsprincipen är den grundläggande rättsprincipen i den straffrätts-liga ansvarsläran som ger besked om att den som inte hade förmåga eller tillfälle att kunna rätta sig efter lagen inte bör bli straffrättsligt ansvarig för ett brott. Detta eftersom ett straffansvar i den situationen hade varit orätt-färdigt och meningslöst. Den som inte kunde rå för sin brottsliga gärning ska således inteThe Conformity Principle is a fundamental legal principle within the Swedish system of criminal liability that states that those who did not have capacity or opportunity to act in accordance with the criminal law should not be punished for a crime. Numerous rules and several legal principles can be derived from The Conformity Principle. The rationale behind the Conformity Principle is that it woul
På senare år har det skett en bred förskjutning i synen på barn- och föräldrarätt. Ett starkare barnrättsperspektiv har etablerats inom svensk rätt och politik. Flera ändringar har gjorts i föräldrabalken. En av dessa ändringar återfinns i 6 kap. 19 § tredje stycket föräldrabalken. I proposition 2020/21:150 föreslog den dåvarande regeringen en lagstadgad tidsgräns på fyra månader när det kommer tiIn recent years, there has been a broad shift in the view of children’s and parental rights. A stronger children’s rights perspective has been established within Swedish law and politics. Several amendments have been made to the Children and Parents Code. One of these amendments can be found in Chapter 6, Section 19, third paragraph of the Children and Parents Code (sw. föräldrabalken (1949:381)).
Title: Inspection of Nation Seminar date: 2024-05-30 Course: FEKH69, Business Administration: Bachelor Degree Project in Financial and Management Accounting Undergraduate level, 15 ECTS-Credits Authors: Ebba Rysjö Lindholm, Julia Skordby, William Lindh Gråsjö Supervisor: Elin Funck Key Words: Internal Control; Risk Management; COSO-Framework; Financial Irregularities; Non-Profit Organizatio
