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Background-Myocardial scarring from infarction or nonischemic fibrosis forms arrhythmogenic substrate. The Selvester QRS score has been extensively validated for estimating myocardial infarction scar size in the absence of ECG confounders. but has not been tested to quantify scar in patients with hypertrophy, bundle branch/fascicular blocks, or nonischemic cardiomyopathy. We assessed the hypothese

Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule,

Epidermolysis bullosa simplex (EBS) is usually inherited as an autosomal dominant disease due to monoallelic gain-of-function mutations in KRT5 or KRT14. Although autosomal recessive forms of EBS have been associated with mutations in at least 10 genes, recessive EBS due to homozygous biallelic KRT5 mutations has not been reported previously; it has been hypothesized that it would result in prenat

Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de

Epidemiological studies show that modifiable risk factors account for approximately 40% of the population variability in risk of developing dementia, including sporadic Alzheimer's disease (AD). Recent findings suggest that these factors may also modify disease trajectories of people with autosomal-dominant AD. With positron emission tomography imaging, it is now possible to study the disease many

Copper (Cu) is one of the most abundant trace metals in all organisms, involved in a plethora of cellular processes. Yet elevated concentrations of the element are harmful, and interestingly prokaryotes are more sensitive for environmental Cu stress than humans. Various transport systems are present to maintain intracellular Cu homeostasis, including the prokaryotic plasmid-encoded multiprotein pc

ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation. Here, we present the cryo-electron microscopy (cryo-EM) structure of human ClC-1, uncovering an architecture reminiscent of that of bovine ClC-K and CLC tran

Background: Dialectical behavior therapy (DBT) is an evidence-based treatment for self-harm and emotion regulation difficulties. A modified version, DBT-Skills System (DBT-SS), has been developed in the USA for individuals with cognitive difficulties. The present study is a pilot study, testing the DBT-SS in a Swedish context.Methods: Six participants were treated with individual therapy and group

Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer risk using a Mendelian randomization analysis. We performed a GWAS of spermidine/spermine ratio to

Microsoft Word - HILMA 2007-08-17.doc HILMA Historiska Institutionen i Lund Meddelar Att… Årgång 33, 2007/08, Nr 1, 2007-08-17 Underlagen till HILMA förvaras i pärmar som står i rum 209, på hyllan ovanför faxen. Där hittar du ytterligare information om seminarier, anställningsvillkor, stipendier och annat samt ansök- ningsblanketter i förekommande fall. De sistnämnda, som är samlade i en separat p

https://www.hist.lu.se/fileadmin/_migrated/content_uploads/hilma_ht07_1_03.pdf - 2025-12-18

On the 1st of July 2018 Sweden changed the law on sexual assault. The new law meant that the prerequisite that separate sexual assault and legal sexual intercourse was changed. In previous legislation coercion was needed for a perpetrator to be convicted of sexual assault. The new law instead places voluntariness at the center of the court’s assessment. The amendment was preceded by much debate. T

Regleringen på aktiemarknaden grundar sig på tanken att samtliga marknadsaktörer ska behandlas lika och få tillgång till samma information samtidigt. Art. 17 MAR utgör exempel på reglering som syftar till att säkerställa denna likabehandling. Artikeln stadgar skyldighet för noterade bolag att offentliggöra insiderinformation och medger endast undantag under särskilda omständigheter. Övervakningen The regulations in the stock market are based on the idea that all market participants shall be treated equally and get access to the same information simultaneously. Article 17 in MAR constitutes an example of regulation that aims at ensuring equality between the market participants. According to the article, listed companies are obligated to disclose inside information and exceptions are only al

Tvångsvård av barn är ett mycket allvarligt ingrepp i den personliga integriteten. För att barn ska kunna tillförsäkras god vård – utan samtycke – måste det därför ställas höga krav på rättssäkerhet. Uppsatsen syftar till att undersöka huruvida rekvisitet något annat socialt nedbrytande beteende i 3 § lag (1990:52) med särskilda bestämmelser om vård av unga (LVU) uppfyller kravet på rättssäkerhet.Compulsory care of a child is a very serious invasion of their privacy. In order to ensure good care of a child – without consent – high requirements must be placed on the legal certainty. This essay intends to examine if the necessary prerequisite any other socially destructive behavior in § 3 the Care of Young Persons Act (CYPA), meets the requirements for legal certainty. Special attention is p

The provision in the Swedish Penal Code Chapter 3 section 1, which regulates the penalty for murder, has been altered several times during the recent years. The latest alteration of the provision took place in July 2014 with the aim that life imprisonment should be the "average penalty". The provision was altered by adding the wording that the penalty for murder should be life imprisonme

Samhället präglas av digital utveckling som anses medföra stora fördelar. Inom det juridiska området tar primärt EU digitaliseringen i anspråk vid sin verksamhet. Sverige har högt uppsatta digitaliseringsmål men är inte lika lyckade som EU på att lagtekniskt följa med i denna utveckling. Med utgångspunkt i digitaliseringen av samhället utreds i den här uppsatsen huruvida det är möjligt att, utifråSociety is characterized by digital development, which is considered to bring great benefits. In the legal field it is primarily the EU that uses means towards digitalization in its operations. Sweden’s goals for digitalization are high but the country has not been as successful as the EU in staying current with the development judicially. With the digitization of society as its basis, this paper

In 2018 Sweden passed a new sexual offence legislation based on consent. The new law came in effect on 1 July. Due to the new law, the lack of consent is now enough to constitute a sexual offence. The sexual offences affected by the new law are rape, 6 kap. 1 § brottsbalken, and sexual abuse 6 kap. 2 § brottsbalken. The interests protected by the sexual offence legislation are the right to self-de

Denna uppsats är skriven på uppdrag av Nordmalings kommun som önskade en djupgående studie av befolkningsminskningen i kommunen. Uppsatsens syfte var att göra en statistisk sammanställning och analys av befolkningen i Nordmalings kommun, för att på så sätt få en överblick på den demografiska utvecklingen. Studien visar att det den 31 december 2008 bodde 7 276 personer i Nordmalings kommun, varav 3

Flyktiga organiska föreningar som släpps ut från växter (BVOC- Biogenic volatile organic compounds) kan ha en stor påverkan på atmosfärisk kemi genom reaktioner som leder till ökad eller minskad ozonproduktion, och genom att de kan vara ett förstadium till aerosoler. De vanligaste flyktiga organiska föreningarna är isopren (2-metyl, 1,3-butadien) och dess derivat, terpener och terpenoider (isoprenBiogenic volatile organic compounds (BVOCs) can have a large affect on atmospheric chemistry by the production or degradation of ozone and by acting as precursors to secondary organic aerosols (SOA). The most common BVOCs are isoprene and its derivatives, terpenes and terpenoids (isoprenoids). These are used by the plant in cell membranes and as steroids, but are also a means of communication and