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The neurodegenerative Huntington's disease (HD) is caused by a polyglutamine (polyQ) amplification in the huntingtin protein (HTT). Currently there is no effective therapy available for HD; however, several efforts are directed to develop and optimize HTT-lowering methods to improve HD phenotypes. To validate these approaches, there is an immediate need for reliable, sensitive, and easily accessib

Background Problematic Internet use is characterized by excessive use of online platforms that can result in social isolation, family problems, psychological distress, and even suicide. Problematic Internet use has been associated with cannabis use disorder, however knowledge on the adult population remains limited. In Quebec, cannabis use has significatively increased since 2018, and it is associ

Aquaporin-0 (AQP0) is the main water channel in the mammalian lens and is involved in accommodation and maintaining lens transparency. AQP0 binds the Ca2+-sensing protein calmodulin (CaM) and this interaction is believed to gate its water permeability by closing the water-conducting pore. Here, we express recombinant and functional human AQP0 in Pichia pastoris and investigate how phosphorylation

Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no con

Background: Patients with cyanotic congenital heart disease (CCHD) may have a low burden of atherosclerosis. Endothelial dysfunction is an early stage of atherosclerosis and endothelial function is previously studied in smaller CCHD groups with different techniques and variable results. We aimed to examine endothelial function and carotid atherosclerosis in a larger group of CCHD patients. Methods

Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML and to investigate its prognostic impact. Complete cytogenetic data were available in 596 patients (

I april 2009 presenterade den europeiska kommissionen det först utkastet för vad som slutligen skulle bli ”alternative investment fund managers” (AIFMD) direktivet. Från början utsattes direktivet för kritik. Direktivets mål är att reglera den inre marknaden för AIF: er (alternativa investeringsfonder). Efter tillägg och omskrivningar antogs slutligen direktivet av Europaparlamentet och EuroparådeIn April 2009 the European Commission presented the first draft of what would eventually become the alternative investment fund managers directive. From the beginning, the directive was subject to criticism. The goal of the directive is to regulate the internal market for AIF: s (alternative investment funds). After amendments and rewrites the European parliament and the European council finally a

Den första Dublinförordningens tillkomst var ett resultat av de institutionella förändringar som följde av Amsterdamfördragets ikraftträdande. Dess upprättande var också ett resultat av de slutsatser som det Europeiska rådet enades om under sitt möte i Tammerfors år 1999. Rådet beslutade då att unionens medlemsstater på sikt skulle ha ett gemensamt asylsystem. Dublinförordningen trädde i kraft åThe first Dublin Regulation was a result of those institutional changes that followed by the Amsterdam Treaty coming into force. The establishment was also a result of the European Council’s conclusions, from their meeting in Tampere in 1999. During the meeting The Council agreed to create a common European asylum system. The Dublin Regulation entered into force in 2003. The purpose of the regul

Title: Is it value creating to invest when no one else dares? - An event study about the M&A relation to the economic cycle Seminar date: 2015-06-04 Course: FEKH89, Degree Project in Finance, Undergraduate level, 15 ECTS-credits Authors: Julia Andersson, Elin Dahlström, Niklas Lindh and Oscar Siöström Supervisor: Rikard Larsson Five key words: M&A, economic cycles, abnormal return, m

The principle of legality in criminal law demands that there must be support in law for an act to constitute a crime and for penalties to be imposed. When the Swedish Supreme Court for the first time was to apply the range of punishment for murder since it changed in July 2014 the principle of legality was of major interest. The Supreme Court chose to ignore the change from 2014 on the grounds tha

Since 2005 an alien can be granted residence permit if, after an overall assessment of the alien’s situation, there are such exceptionally distressing circumstances that he or she should be allowed to stay in Sweden. In July 2014 a provision came in force which stipulates that children may stay in Sweden if there are particularly distressing circumstances. The purpose of this thesis is to determin

Title: Barriers to Sustainable Investing Seminar date: 2021-06-02 Course: FEKH29, Bachelor Degree Project in Marketing Undergraduate Level, 15 ECTS Authors: Julia Benke, Filippa Kjellberg, Ida Svensson Advisor: Peter Svensson Key words: Barriers, Gaps, Sustainability, Intention, Attitude, Behavior Research question: Which barriers obstruct sustainable investing? Purpose: The study aims to contrib

I 29 kap. 1 § brottsbalken anges att straffet för ett brott ska bestämmas inom ramen för den tillämpliga straffskalan efter brottets straffvärde. Straffvärdet för ett brott kan anses spegla brottets allvarlighet och flera omständigheter kan påverka straffvärdet. I 29 kap. 2 § BrB anges försvårande omständigheter som påverkar straffvärdet i skärpande riktning. Hedersmotiv kan beaktas inom ramen fChapter 29 section 1 of The Swedish Criminal Code, hereafter called SCC, states that the penalty shall be determined within the framework of the applicable scale of penalties according to the penalty value of the offence. The penalty value can be considered a reflection of the seriousness of the offence. There are a number of circumstances which may affect the penalty value. Chapter 29 section 2 S

The Swedish Government wants to fight honor-related crime and believes that the introduction of a special honor crime is a way to further highlight that such violence is unacceptable. Therefore, in July 2019, the Government commissioned a special investigator to analyze and take a position on a special criminal provision that explicitly aims at honor-realtered violence and oppression. The inquiry

On 1st of July 2018 a new sexual crime law was introduced in Sweden. The Swedish sexual crime law is now based on explicit consent. The law also introduces a new offence, negligent rape. The negligence aspect means that intent is not required to be convicted of rape, punishment can be claimed in gross negligence. Gross negligence means that the perpetrator has been deliberately negligent, and in s

On July 1st, 2018, a reform regarding the Swedish sexual offence legislation came into force, which meant that the crime of rape in Chap. 6 § 1 of the Penal Code was constructed around the concept of voluntariness instead of around the concept of coercion. The new offence negligent rape was also introduced in Chap 6. § 1 a of the Penal Code. The paragraph regarding rape is still based on previous

Title:​ Profit-sharing foundations’ impact on organizational attractiveness - A study on the relationship within Svenska Handelsbanken Seminar date:​ 2019-01-17 Course: FEKH19 Business Administration: Bachelor Degree Project in Strategic Management, Undergraduate level, 15 University Credits Points Authors:​ Caroline Barle, Johanna Delshammar, Julia Hänström Advisor:​ Merle Jacob Five key words:

Svenskt ställföreträdarskap för vuxna består av möjligheten att utse en god man eller förvaltare. Tidigare fanns en möjlighet att upprätta en fullmakt för någon som kunde hjälpa den enskilda även efter att denna p.g.a. ålder eller annan orsak inte längre var beslutsförmögen. Det förfarandet kritiserades på många håll, inte minst genom NJA 2015 s. 851. Av denna anledning pågår arbetet för att anta Swedish deputisation for adults comprises the possibility to designate an administrator or trustee. Earlier, there were a possibility to nominate a proxy agent to assist individuals with their affairs even after a they due to old age or any other reason not were able to. This procedure has become questioned, not least in the Swedish Supreme Court, NJA 2015 s. 851. Due to this reason, the Swedish g

Staden Frutal, centrerad i den brasilianska delstaten Minas Gerais är idag under stark urbanisering och utveckling. Målet med denna studie var att ta reda på om den starka urbaniseringen har påverkat närliggande vattensystem och dess vattenkvalité. I studien har vattenkvalitén i floden Frutal, en flod liggandes centralt i staden Frutal, jämförts med vattenkvalitén i floden Bebedouro, en lantlig flThis study highlights the key issues that urban river systems face due to urbanization. The city of Frutal (20°01' 32.17”S 48°56' 09.62” W) centered in the Brazilian state of Minas Gerais is under urban expansion today. The aim of this study was to compare two rivers in this area, the Frutal River, an urban located river, with the Bebedouro River, which is a rural river approximately 3 km