Sökresultat

Epidemiological studies show that modifiable risk factors account for approximately 40% of the population variability in risk of developing dementia, including sporadic Alzheimer's disease (AD). Recent findings suggest that these factors may also modify disease trajectories of people with autosomal-dominant AD. With positron emission tomography imaging, it is now possible to study the disease many

Copper (Cu) is one of the most abundant trace metals in all organisms, involved in a plethora of cellular processes. Yet elevated concentrations of the element are harmful, and interestingly prokaryotes are more sensitive for environmental Cu stress than humans. Various transport systems are present to maintain intracellular Cu homeostasis, including the prokaryotic plasmid-encoded multiprotein pc

Background-Myocardial scarring from infarction or nonischemic fibrosis forms arrhythmogenic substrate. The Selvester QRS score has been extensively validated for estimating myocardial infarction scar size in the absence of ECG confounders. but has not been tested to quantify scar in patients with hypertrophy, bundle branch/fascicular blocks, or nonischemic cardiomyopathy. We assessed the hypothese

Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule,

Epidermolysis bullosa simplex (EBS) is usually inherited as an autosomal dominant disease due to monoallelic gain-of-function mutations in KRT5 or KRT14. Although autosomal recessive forms of EBS have been associated with mutations in at least 10 genes, recessive EBS due to homozygous biallelic KRT5 mutations has not been reported previously; it has been hypothesized that it would result in prenat

Background: Dialectical behavior therapy (DBT) is an evidence-based treatment for self-harm and emotion regulation difficulties. A modified version, DBT-Skills System (DBT-SS), has been developed in the USA for individuals with cognitive difficulties. The present study is a pilot study, testing the DBT-SS in a Swedish context.Methods: Six participants were treated with individual therapy and group

Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer risk using a Mendelian randomization analysis. We performed a GWAS of spermidine/spermine ratio to

ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation. Here, we present the cryo-electron microscopy (cryo-EM) structure of human ClC-1, uncovering an architecture reminiscent of that of bovine ClC-K and CLC tran

Microsoft Word - ENSO V second call for paper 20161201.docx ENSO  V     The  Fifth  Conference  of  the  European  Network  on  Social  Ontology   Lund,  Sweden   August  30  –  September  1,  2017     SECOND  CALL  FOR  PAPERS  –  SUBMISSION  OPEN  DEC  1st     The  European  Network  on  Social  Ontology  invites  contributions  to  its  fifth  conference.  ENSO   V  is  an  interdisciplinary  c

https://konferens.ht.lu.se/fileadmin/_migrated/content_uploads/ENSO_V_second_call_for_paper_20161201_01.pdf - 2025-12-11

Thursday May 16th Room: Arrival: 12:30-12:40 Scandinavian Literature in the World Nordic Languages in the World / World Languages in the Nordic Countries Translations of Scandinavian Literature Room: H135a H135b H140 Afternoon sessions: 12:40-13:00 Agata Lubowicka Bjarne Købmand Petersen Els Biesemans 13:00-13:20 Jens Lohfert Jørgensen Frederic Pearl Catia De Marco 13:20-13:40 Krzysztof Bak* Crist

https://www.css.lu.se/fileadmin/user_upload/project/css/CSS_Conference_2019_-_Revised_Schedule_-__2019-05-14.pdf - 2025-12-11

Samhället präglas av digital utveckling som anses medföra stora fördelar. Inom det juridiska området tar primärt EU digitaliseringen i anspråk vid sin verksamhet. Sverige har högt uppsatta digitaliseringsmål men är inte lika lyckade som EU på att lagtekniskt följa med i denna utveckling. Med utgångspunkt i digitaliseringen av samhället utreds i den här uppsatsen huruvida det är möjligt att, utifråSociety is characterized by digital development, which is considered to bring great benefits. In the legal field it is primarily the EU that uses means towards digitalization in its operations. Sweden’s goals for digitalization are high but the country has not been as successful as the EU in staying current with the development judicially. With the digitization of society as its basis, this paper

In 2018 Sweden passed a new sexual offence legislation based on consent. The new law came in effect on 1 July. Due to the new law, the lack of consent is now enough to constitute a sexual offence. The sexual offences affected by the new law are rape, 6 kap. 1 § brottsbalken, and sexual abuse 6 kap. 2 § brottsbalken. The interests protected by the sexual offence legislation are the right to self-de

Förhöjda temperaturer på höga breddgrader kan förändra koldynamiken i hela Arktis. Modellerade CO2 simuleringar visar att under nuvarande klimatförhållanden utgör Arktis en netto kolsänka, fast den stora utsträckningen samt fina geografiska heterogenitet lyfter upp osäkerhet kring dess status som CO2 sänka/källa i regionen. Förståelsen för arktiska koldioxidflödekan förbättras genom integrering avIncreased temperatures in high latitudes may alter the carbon dynamics throughout the Arctic. Modelled CO2 simulations show that current climate conditions constitute the Arctic a net carbon sink, though the large extent and fine landscape heterogeneity raise an uncertainty about the carbon sink/source status of the region. The understanding of Arctic CO2 fluxes can be improved through integration

Denna rapport är en del av Folkhälsomyndighetens uppdrag om att sprida kunskapinom miljörelaterad hälsa för att främja en miljö som bidrar till en god och jämlikhälsa i befolkningen. Rapporten riktar sig främst till beslutsfattare och handläggaresom arbetar med miljörelaterad hälsa på nationell, regional och lokal nivå. Denutgör ett viktigt beslutsunderlag för prioriteringar och åtgärder inom detm

Tvångsvård av barn är ett mycket allvarligt ingrepp i den personliga integriteten. För att barn ska kunna tillförsäkras god vård – utan samtycke – måste det därför ställas höga krav på rättssäkerhet. Uppsatsen syftar till att undersöka huruvida rekvisitet något annat socialt nedbrytande beteende i 3 § lag (1990:52) med särskilda bestämmelser om vård av unga (LVU) uppfyller kravet på rättssäkerhet.Compulsory care of a child is a very serious invasion of their privacy. In order to ensure good care of a child – without consent – high requirements must be placed on the legal certainty. This essay intends to examine if the necessary prerequisite any other socially destructive behavior in § 3 the Care of Young Persons Act (CYPA), meets the requirements for legal certainty. Special attention is p

The provision in the Swedish Penal Code Chapter 3 section 1, which regulates the penalty for murder, has been altered several times during the recent years. The latest alteration of the provision took place in July 2014 with the aim that life imprisonment should be the "average penalty". The provision was altered by adding the wording that the penalty for murder should be life imprisonme

On the 1st of July 2018 Sweden changed the law on sexual assault. The new law meant that the prerequisite that separate sexual assault and legal sexual intercourse was changed. In previous legislation coercion was needed for a perpetrator to be convicted of sexual assault. The new law instead places voluntariness at the center of the court’s assessment. The amendment was preceded by much debate. T