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Det funktionella undantaget - En studie av gränsdragningen mellan mönsterskydd och teknisk funktion

On the 1 of July 2002 the Directive 98/71/EC of the European Parliament and of the Council on the legal protection of designs was implemented in the Swedish Design Protection Act (1970:485). The harmonization of the design rights within the EU brought an exemption provision contained in section 4 a § 1 pc. 1p. in the Design Protection Act (1970: 485), which statutes that a design right must not su

Otukt mot naturen, vems natur? Om avkriminaliseringen av homosexualiteten

Engelsk sammanfattning Due to the entry into force for a decriminalization regarding homosexuality in July 1944, homosexual activities were not considered as something criminal anymore. The struggle towards a more equal society did not end there. It took until 1979 before homosexuality was removed from the National Board of Health and Welfare (Socialstyrelsens) register of illnesses. Today, homos

Uppskjutet offentliggörande av insiderinformation i en utdragen process

Under de senaste femtio åren har de europeiska kapitalmarknaderna blivit allt mer integrerade. För att garantera allmänhetens förtroende, för att förhindra framtida finanskriser och för att nå den ekonomiska effektiviteten på marknaden, är det viktigt att det finns harmoniserade förbud mot marknadsmissbruk. En vanlig form av marknadsmissbruk är handel med insiderinformation, som kan leda till stoDuring the last fifty years, the European capital markets have become increasingly integrated. In order to ensure public confidence, to prevent future financial crises and to reach economic efficiency on the market, it is of importance that there are harmonised prohibitions against market abuse. A common form of market abuse on the European market is trading with inside information, which can lea

Bestraffningsteorier och ungdomspåföljderna

Den svenska straffrätten har under det senaste århundradet genomgått en mängd förändringar. Allt som oftast har påföljdssystemet varit utformad efter de för tillfället förhärskande bestraffningsteorierna. Det finns en lång tradition av särbehandling av unga lagöverträdare i Sverige och till viss del så tas hänsyn till andra intressen när det gäller ungdomar. Denna framställning ska besvara frågornSwedish penal law has undergone many changes over the last centuries. The sanction system has most often been modelled on penalization theories dominant at the time. Sweden has a long tradition of special treatment of young offenders, and other interest are to some extent taken into consideration when it comes to juvenile offenders compared to adults. This essay will answer the questions of which

Groddjursinventering i NV Skåne

Många groddjur har minskande populationstrender både lokalt och globalt. Inventeringar av groddjur är en viktig del av arbetet för att få mer information om deras utbredning för att kunna skydda groddjuren och deras miljöer. Detta kan ha positiva effekter även på andra djur och växter eftersom groddjur är bra indikatorer på rika miljöer. Genom sitt vattenupptag via huden är groddjuren extremt käns

Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay

The neurodegenerative Huntington's disease (HD) is caused by a polyglutamine (polyQ) amplification in the huntingtin protein (HTT). Currently there is no effective therapy available for HD; however, several efforts are directed to develop and optimize HTT-lowering methods to improve HD phenotypes. To validate these approaches, there is an immediate need for reliable, sensitive, and easily accessib

Trisomy 8 in pediatric acute myeloid leukemia : A NOPHO-AML study

Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML and to investigate its prognostic impact. Complete cytogenetic data were available in 596 patients (

The 10,000-year biocultural history of fallow deer and its implications for conservation policy

Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no con

Pharmacogenomic Association of Nonsynonymous SNPs in SIGLEC12, A1BG, and the Selectin Region and Cardiovascular Outcomes

We sought to identify novel pharmacogenetic markers associated with cardiovascular outcomes in patients with hypertension on antihypertensive therapy. We genotyped a 1:4 case:control cohort (n=1345) on the Illumina HumanCVD Beadchip from the INternational VErapamil SR-Trandolapril STudy (INVEST), where participants were randomized to a -blocker strategy or a calcium channel blocker strategy. Genom

Cannabis use, mental health, and problematic Internet use in Quebec : A study protocol

Background Problematic Internet use is characterized by excessive use of online platforms that can result in social isolation, family problems, psychological distress, and even suicide. Problematic Internet use has been associated with cannabis use disorder, however knowledge on the adult population remains limited. In Quebec, cannabis use has significatively increased since 2018, and it is associ

LED's Buy Greener: Shedding Light on Sustainable Procurement

In last decade, the lighting industry significantly changed with the development of light emitting diodes (LEDs) and their corresponding penetration of the market. The new technology increases energy efficiency and longevity compared to other types of lamps. As a result, LEDs can improve the sustainability performance of cities and towns, contributing to the mitigation of climate change and cuttin

The role of phosphorylation in calmodulin-mediated gating of human AQP0

Aquaporin-0 (AQP0) is the main water channel in the mammalian lens and is involved in accommodation and maintaining lens transparency. AQP0 binds the Ca2+-sensing protein calmodulin (CaM) and this interaction is believed to gate its water permeability by closing the water-conducting pore. Here, we express recombinant and functional human AQP0 in Pichia pastoris and investigate how phosphorylation

Vascular function in adults with cyanotic congenital heart disease

Background: Patients with cyanotic congenital heart disease (CCHD) may have a low burden of atherosclerosis. Endothelial dysfunction is an early stage of atherosclerosis and endothelial function is previously studied in smaller CCHD groups with different techniques and variable results. We aimed to examine endothelial function and carotid atherosclerosis in a larger group of CCHD patients. Methods