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Penicillin blocks human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) GABA(A) channels that open spontaneously.

We used the open-channel blocker, penicillin (10 mM), as a tool to investigate if the human α1β1 or α1β1γ2S γ-aminobutyric acid type A (GABAA) receptor channels opened in the absence of GABA. Application of penicillin to cells expressing the receptors resulted in a transient inward whole-cell current, the off-current, upon penicillin removal. The amplitude of the off-current was dependent on the d

Maternal depressive symptoms have a negative impact on prenatal attachment – findings from a Swedish community sample

Objective: The objective of this study was to evaluate attachment and its association to obstetric and demographic factors as well as emotional well-being using a standard measure of prenatal attachment during pregnancy. Background: The strength of the mothers’ relationship with her baby has important implications in the postnatal period, influencing the relationship she develops with her child, a

The role of women's attitudinal profiles in satisfaction with the quality of their antenatal and intrapartum care

Objective: To compare perceptions of antenatal and intrapartum care in women categorized into three profiles based on attitudes and fear. Design: Prospective longitudinal cohort study using self-report questionnaires. Profiles were constructed from responses to the Birth Attitudes Profile Scale and the Fear of Birth Scale at pregnancy weeks 18 to 20. Perception of the quality of care was measured

Danish women's experiences of the rebozo technique during labour : A qualitative explorative study

Objective The study aimed to explore women's experiences of the rebozo technique during labour. Methods This was a qualitative study based on individual telephone interviews, analysed by means of qualitative content analysis and inspired by interpretive description. 17 participants were recruited from two different-sized Danish hospitals and identified by applying a purposeful sample strategy. Res

Perioperative alcohol cessation intervention for postoperative complications

Background: Risky consumption of alcohol is a global problem. More than 3.3 million deaths annually are associated with risky use of alcohol, and global alcohol consumption continues to increase. People who have high alcohol consumption often require planned and emergency surgical procedures. Risky drinking is associated with increased postoperative complications such as infections, cardiopulmonar

Factors Associated With Pathogenicity of Anti-Glomerular Basal Membrane Antibodies : A Case Report

Antiglomerular basement membrane (GBM) disease is known as a super-acute proliferative glomerulonephritis caused by auto-antibodies targeting the NC1 domain of the α3 chain of type IV collagen.Here, we describe a case of atypical anti-GBM disease presenting as a dialysis-dependent acute renal failure with unusual mild glomerular involvement. We found that immunoglobulin G (IgG) deposits were restr

Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease

Mouse embryonic stem cell (mESC) lines were derived by crossing heterozygous transgenic (tg) mice expressing green fluorescent protein (GFP) under the control of the rat tyrosine hydroxylase (TH) promoter, with homozygous alpha-synuclein (aSYN) mice expressing human mutant SNCAA53T under the control of the mouse Prion promoter (MoPrP), or wildtype (WT) mice. The expression of GFP and human aSYN wa

Translation and validation of the hospital for special surgery pediatric functional activity brief scale for french paediatric populations

Purpose: Physical activity level is a prognostic variable for patients with injuries. Self-report questionnaires exist to obtain these measures; however, they are not accessible to all populations because of language barriers. Therefore, the purpose of this study was to translate and validate the Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) for francophone

Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis

Popular Abstract in Swedish Leukemi kännetecknas av en okontrollerad tillväxt av omogna vita blodkroppar och orsakas av förvärvade genetiska förändringar. Genetiska förändringar eller avvikelser, som är drivande i cancerutvecklingen, uppstår när normala celler delar sig. Identifiering av sådana förändringar på gen-och kromosomnivå är av stor klinisk betydelse. Behandling styrs av vilka genetiska aAcute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children <4 years and adults >50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. In contrast to pediatric ALL, which has a favorable prognosis, adult ALL is associated with a much poorer outcome with less than 40% overall

Accelerating inference for diffusions observed with measurement error and large sample sizes using approximate Bayesian computation

In recent years, dynamical modelling has been provided with a range of breakthrough methods to perform exact Bayesian inference. However, it is often computationally unfeasible to apply exact statistical methodologies in the context of large data sets and complex models. This paper considers a nonlinear stochastic differential equation model observed with correlated measurement errors and an appli

HIV-1 Enhancing Effect of Prostatic Acid Phosphatase Peptides Is Reduced in Human Seminal Plasma

We recently reported that HIV-1 infection can be inhibited by innate antimicrobial components of human seminal plasma (SP). Conversely, naturally occurring peptidic fragments from the SP-derived prostatic acid phosphatase ( PAP) have been reported to form amyloid fibrils called "SEVI'' and enhance HIV-1 infection in vitro. In order to understand the biological consequence of this proviral effect,

Evidence for Dysfunction of the Nigrostriatal Pathway in the R6/1 Line of Transgenic Huntington's Disease Mice.

The present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxylase-positive neurons was not reduced and nigrostriatal connectivity remained intact in 16-week-old R6/1 mice, the size of tyrosine hydroxy

MRI-Derived AD Signature of Cortical Thinning and Plasma P-Tau217 for Predicting Alzheimer Dementia Among Community-Dwelling Older Adults

Background and Objectives Structural brain MRI and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive Alzheimer's disease (AD) biomarkers to date. The extent to which these biomarkersmay outperformone another in predicting future Alzheimer dementia diagnosis is poorly understood, however. This study investigated 2 specific AD biomarkers, i.e., a cortic

Insights into interstitial lung disease pathogenesis

This review summarises some of the key features of interstitial lung diseases (ILDs) from a translational science point of view and brings insights into potential therapeutic options. Genetic predisposition and environmental factors like smoking, pollution and infections significantly impact the onset, progression and treatment response in ILDs, highlighting the need for personalised management. F

Hans-Heinrich Vogel

Professor emeritus Kontaktinformation E-post: hans-heinrich [dot] vogel [at] jur [dot] lu [dot] se Telefon: +46 46 222 10 94Organisation Juridiska institutionen Rumsnummer: 320 Hämtställe: 56 WebbplatsHans-Heinrich Vogels profil i Lunds universitets forskningsportalAndra roller Forskare Offentlig rätt Publikationer Visar av publikationer. Sorterade efter år och sen titel. Filtrera efter typ AllaAr

https://www.jur.lu.se/hans-heinrich-vogel - 2025-12-02

No title

No. 4 2019 M O D E V E T E N S K A P Vid Lunds Universitet H Ä L S N I N G F R Å N S T UD I E R Å D E T Modevetare, nu börjar April månad och vårvädret har redan börjat sprida sig i Skåne. Påsken vilar runt hörnet, och vi hoppas att det innebär lite ledigt med nära och kära. Vad händer på det modevetenskapliga programmet då? Både studerande på termin två och fyra åker på studiebesök till Stockholm

https://www.kultur.lu.se/fileadmin/user_upload/kultur/Utbildning/Mode_maanadsbrev/Ma__nadsbrev_April_2019.pdf - 2025-12-01

Granskning av kommunala utmaningar för implementeringen av nya rökfria miljöer

Skånes kommuner känner sig osäkra inför nya rökförbud Intervjuer med tjänstemän från Skånes kommuner visar på att de känner sig osäkra inför implementeringen av rökfria miljöer som presenteras i den nya tobakslagen. Folkhälsomyndigheten har bara en månad innan lagen träder i kraft kommit ut med den information som kommunerna behöver. Flera kommuner riskerar därför att falla efter i tillsynen av lThe Law of Tobacco and Similar Products becomes active on the 1st of July 2019 and brings with it new no-smoking areas, primarily in outdoor environments, which will demand municipal supervision. In this study, officials from Scania’s municipalities have been interviewed to investigate what their opinions, views and expected challenges with the implementation of these no-smoking areas are. It was

LU-gemensamt Mejlutskick Nr 20-v22-2021

NYTT FRÅN LUNDS UNIVERSITET Mejlutskick på svenska och engelska som vänder sig till fakultetskommunikatörer vid Lunds universitet för vidarespridning i fakultets- och institutionskanaler – Nr 20 v 22 - 2021. UNIVERSITETSGEMENSAMT Lönerevisionen drar ut på tiden Förhandlingarna med anledning av lönerevisionen pågår fortfarande. Tyvärr kan det konstateras att det nu har dragit ut så långt i tiden at

https://www.cec.lu.se/sites/cec.lu.se/files/2021-06/LU-gemensamt%20Mejlutskick%20Nr%2020-v22-2021.pdf - 2025-12-02

2011 hello freddie

FOLDER 3 Universitetsbibliotekets utställningskatalog 60 28 Universitetsbiblioteket, Lunds universitet Box 3, 221 00 LUND UB Media. ISSN 0281-3823, LULID/LIBR - 1548 4 februari - 22 maj 2011 Brevsamlingen Vänskapen och kontakten mellan den svenske konstnären och författaren Gösta Adrian-Nilsson (GAN, 1884-1965) och den danske surrealistiske konstnären Wilhelm Freddie (1909-1995) har hittills varit

https://www.ub.lu.se/en/sites/ub.lu.se.en/files/2011_hello_freddie.pdf - 2025-12-02