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Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.
Mutations in alpha-synuclein have been linked to rare, autosomal dominant forms of Parkinsons disease. Despite its ubiquitous expression, mutant alpha-synuclein primarily leads to the loss of dopamine-producing neurons in the substantia nigra. Alpha-synuclein is a presynaptic nerve terminal protein of unknown function, though some studies suggest it is important for synapse formation and maintenan
Integrative taxonomy confirms that Gregarina garnhami and G. acridiorum (Apicomplexa, Gregarinidae), parasites of Schistocerca gregaria and Locusta migratoria (Insecta, Orthoptera), are distinct species
Orthoptera are infected by about 60 species of gregarines assigned to the genus Gregarina Dufour, 1828. Among these species, Gregarina garnhami Canning, 1956 from Schistocerca gregaria (Forsskål, 1775) was considered by Lipa et al. in 1996 to be synonymous with Gregarina acridiorum (Léger 1893), a parasite of several orthopteran species including Locusta migratoria (Linné, 1758). Here, a morpholog
Synthesis of CdS nanocrystals in polymeric films studied by in-situ GID and GISAXS
In this work, we describe the synthesis of CdS nanocrystals in thin polymeric films by in-situ Grazing Incidence Diffraction (GID) and Grazing Incidence Small Angle Scattering (GISAXS). The 2D GISAXS patterns indicate how the precursor structure is altered as the temperature is varied from 25°C to 300°C. At 150°C, the CdS nanocrystals start to arrange themselves in a hexagonal lattice with a latti
New Measures for Governing Religions in Xi’s China
With the incorporation of the State Administration for Religious Affairs (SARA) into the Chinese Communist Party’s (CCP) United Front Work Department in 2018, religious affairs have been brought back into the direct control of the Party. While SARA has retained its name, it is no longer an independent state agency. Five further legal measures were introduced from 2019 to 2021. This review essay ex
Prenatal alcohol exposure before pregnancy awareness: a thematic analysis of online forum comments and misinformation
Background: Many women consume alcohol while pregnant before they are aware of the pregnancy, raising concerns about potential harms to the developing fetus. Official guidelines in the United Kingdom recommend abstinence throughout pregnancy, and many women turn to online forums for reassurance and information. However, online forums can also become a source of misinformation, potentially increasi
Elephants, bushes, hot porridge… and clinical intuition?
Accelerating delayed-acceptance Markov chain Monte Carlo algorithms
Delayed-acceptance Markov chain Monte Carlo (DA-MCMC) samples from a probability distribution, via a two-stages version of the Metropolis-Hastings algorithm, by combining the target distribution with a "surrogate" (i.e. an approximate and computationally cheaper version) of said distribution. DA-MCMC accelerates MCMC sampling in complex applications, while still targeting the exact distribution. W
Politiskt ledarskap under kris - En utredning av ledarskapet under finanskrisen och covid19 pandemin
The purpose of this thesis is to examine how political leadership takes shape and is expressed during crisis management. This is done through an analysis of Fredrik Reinfeldtś management of the 2008 financial crisis and Stefan Löfvenś management of the Covid19 pandemic. This thesis focuses on how different leadership styles have been used to meet the specific challenges of each crisis. With the he
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Utbildn kurspl master blfl13
Utbildn kurspl master sang13
AstraZeneca-domen - Tufft besked för originaltillverkare
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Musikerutbildning interpretation diplom
Utbildnings utbplan kandidat ky2 old
Integrating genetics with newborn metabolomics in infantile hypertrophic pyloric stenosis
Introduction: Infantile hypertrophic pyloric stenosis (IHPS) is caused by hypertrophy of the pyloric sphincter muscle. Objectives: Since previous reports have implicated lipid metabolism, we aimed to (1) investigate associations between IHPS and a wide array of lipid-related metabolites in newborns, and (2) address whether detected differences in metabolite levels were likely to be driven by genet
Physio-chemical analysis of airborne tire wear particles
Supporting Entrepreneurship and Innovation in Higher Education in Lithuania
Changes in climate, technology and demography as well as the COVID-19 pandemic are transforming our societies and way of life. The EU Member States, as elsewhere, need a strong higher education sector, as an engine of innovation and entrepreneurship and driver of skills and knowledge. As the conditions in which our societies operate are changing, there is broad consensus that higher education inst
