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The carotid-to-femoral pulse wave velocity, determined by pulse transit time (PTT) and distance, is a well-established measure of arterial stiffness and predicts adverse outcomes. However, its predictive value decreases with aging. To explore new risk indicator in the elderly, we investigated if the variation of carotid-to-femoral pulse wave velocity, registered as beat-to-beat variability of caro

Background & Aims Predniso(lo)ne, alone or in combination with azathioprine, is the standard-of-care (SOC) therapy for autoimmune hepatitis (AIH). However, the SOC therapy is poorly tolerated or does not control disease activity in up to 20% of patients. We assessed the efficacy of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy for patients with AIH. Methods We performed a r

Following a brief review of the development of medical ultrasonics from the mid-1930s to the mid-1950s, the collaboration between Edler and Hertz that began in Lund in 1953 is described. Using an industrial ultrasonic flaw detector, they obtained time-varying echoes transcutaneously from within the heart. The first clinical applications of M-mode echocardiography were concerned with the assessment

This thesis presents applications of the Scheimpflug Lidar (S-Lidar) method. The technique has been applied to combustion diagnostics on a scale of several meters as well as fauna detection and monitoring over distances of kilometers. Lidar or laser radar is a remote sensing technique where backscattering of laser light is detected with range resolution along the direction of the laser beam. It is

Muscarinic acetylcholine receptors (mAChRs) play a central role in the mammalian nervous system. These receptors are G protein-coupled receptors (GPCRs), which are activated by the agonists acetylcholine and muscarine, and blocked by a variety of antagonists. Mammals have five mAChRs (m1-m5). In this study, we cloned two structurally related GPCRs from the fruit fly Drosophila melanogaster, which,

English is widely recognized as the language of science, and English-language publications (ELPs) are rapidly increasing. It is often assumed that the number of non-ELPs is decreasing. This assumption contributes to the underuse of non-ELPs in conservation science, practice, and policy, especially at the international level. However, the number of conservation articles published in different langu

BACKGROUND: Endolichenic fungi are microbes that inhabit the thalli of lichens and produce various unique chemicals that can be used for pharmaceutical purposes.PURPOSE: This study screened a library of endolichenic fungal extracts to identify novel anticancer agents capable of suppressing the tumorigenicity of human cancer cells.METHODS: Active compounds were isolated from extracts of endolicheni

Accurate monitoring of glaciers’ extents and their dynamics is essential for improving our understanding of the impacts of climate and environmental changes in cold regions. The satellite-based Normalized Difference Snow Index (NDSI) has been widely used for mapping snow cover and glaciers around the globe. However, mapping glaciers in snow-covered areas using existing indices remains a challengin

Climate warming is expected to accelerate glacier retreat and shift hydrological regime, which poses great threat to regional water resources in terms of amount, variability, and quality. This is especially true in arid regions with glaciers such as the Central Asia. However, few models manage to mimic both glacier runoff and surface changes with adequate performance. To narrow this gap, we integ

Late Permian mass extinction (LPME) research has focused primarily on Tethyan sections because it is believed that these successions are more complete than those from other localities, and provide a more comprehensive record of the largest, most devastating extinction event in Earth history. The Kisejin section, a previously undocumented mid-Tethyan, Upper Permian-Lower Triassic succession located

The first authoritative overview of tourism studies published post-COVID-19 The Wiley Blackwell Companion to Tourism remains a definitive reference in this interdisciplinary field. Edited and authored by leading scholars from around the world, this state-of-the-art volume provides a comprehensive critical overview of tourism studies across the social sciences. In-depth yet accessible chapters comb

The purpose of this thesis has been to analyse the mechanism of the market driving approach carried out by a global organisation with a corporate brand. Market driving is a new organisational approach to strategy that lacks a solid theoretical framework, but constitutes a reality of global firms such as IKEA, The Body Shop, Benetton, Dell, Hennes and Mauritz, Starbucks. In the literature, the mark

Determining the appropriate duration for traffic conflict observation remains a critical yet unresolved challenge in road safety analysis. Existing approaches lack a quantitative approach to determine adequate sample sizes for general conflict-based applications. This study addresses this gap by proposing an extreme value theory based framework to determine appropriate observation durations, based