Sökresultat

Filtyp

Din sökning på "*" gav 531332 sökträffar

Gudar och människor bland texter och paratexter : Om varför Gamla testamentet inte har några författare

It is a wellknown fact that the books of the Hebrew Bible are, to a great extent, anonymous and that the individuals long identified as their authors (Moses, Isaiah, David, Solomon, and so on) are not the ones who have penned them. How, then, should the few paratexts that do, in fact, relate texts explicitly to named individuals be understood? In this article, I argue that such a question is essen

Impact of comorbidity in older patients with peripheral T-cell lymphoma : an international retrospective analysis of 891 patients

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of aggressive neoplasms with poor outcomes, commonly affecting older patients with comorbidities. This study aims to describe outcomes of older patients with PTCL in a large international cohort. Patients aged $70 years with PTCL diagnosed from 1 January 2010 to 31 December 2015 in the Swedish Lymphoma Registry (SLR) and California Cancer

Gene-environment interactions and metal toxicity

Humans are exposed to various metals through many different routes and each person’s genetic background contributes to their susceptibility to metal toxicity. In addition, recent evidence points to a role for the genetics of the human microbiome in metal uptake and toxicity. DNA sequence variation in genes that regulate metal toxicokinetics and toxicodynamics influences metal accumulation and rete

Structure of an Ultrathin Oxide on Pt3Sn(111) Solved by Machine Learning Enhanced Global Optimization**

Determination of the atomic structure of solid surfaces typically depends on comparison of measured properties with simulations based on hypothesized structural models. For simple structures, the models may be guessed, but for more complex structures there is a need for reliable theory-based search algorithms. So far, such methods have been limited by the combinatorial complexity and computational

The loyal defence lawyer

The work of defence lawyers entails managing emotions to ensure that they remain appropriate to the situation - whether that be a criminal trial or the law offices. This demands emotional dexterity and interactional skill, not least due to the particular role of defence lawyers who work closely with clients, view gruesome evidence and who often face moral suspicion. This chapter explores the vario

Acute echocardiographic and hemodynamic response to his-bundle pacing in patients with first-degree atrioventricular block

Background: Atrial pacing and right ventricular (RV) pacing are both associated with adverse outcomes among patients with first-degree atrioventricular block (1°AVB). His-bundle pacing (HBP) provides physiological activation of the ventricle and may be able to improve both atrioventricular (AV) and inter-ventricular synchrony in 1°AVB patients. This study evaluates the acute echocardiographic and

Microgravity crystallization of perdeuterated tryptophan synthase for neutron diffraction

Biologically active vitamin B6-derivative pyridoxal 5′-phosphate (PLP) is an essential cofactor in amino acid metabolic pathways. PLP-dependent enzymes catalyze a multitude of chemical reactions but, how reaction diversity of PLP-dependent enzymes is achieved is still not well understood. Such comprehension requires atomic-level structural studies of PLP-dependent enzymes. Neutron diffraction affo

Yeast and fruit fly mutual niche construction and antagonism against mould

A goal in insect–microbe ecology is to understand the mechanisms regulating species associations and mutualistic interactions. The spotted wing drosophila Drosophila suzukii develops in ripening fruit, unlike other drosophilids that typically feed on overripe fruit, and is associated with the yeast Hanseniaspora uvarum. We hypothesized that D. suzukii and H. uvarum engage in niche construction lea

Androgen receptor reprogramming demarcates prognostic, context-dependent gene sets in primary and metastatic prostate cancer

The androgen receptor (AR) is a prostate master transcription factor. It binds to genetic enhancers, where it regulates gene activity and plays a fundamental role in prostate pathophysiology. Previous work has demonstrated that AR-DNA binding is systematically and consistently reprogrammed during prostate tumorigenesis and disease progression. We charted these reprogrammed AR sites and identified

Alternative splicing modulation by G-quadruplexes

Alternative splicing is central to metazoan gene regulation, but the regulatory mechanisms are incompletely understood. Here, we show that G-quadruplex (G4) motifs are enriched ~3-fold near splice junctions. The importance of G4s in RNA is emphasised by a higher enrichment for the non-template strand. RNA-seq data from mouse and human neurons reveals an enrichment of G4s at exons that were skipped

Novel protein markers of androgen activity in humans : proteomic study of plasma from young chemically castrated men

Background: Reliable biomarkers of androgen activity in humans are lacking. The aim of this study was, therefore, to identify new protein markers of biological androgen activity and test their predictive value in relation to low vs normal testosterone values and some androgen deficiency linked pathologies. Methods: Blood samples from 30 healthy GnRH antagonist treated males were collected at three

Internal electric field engineering step-scheme–based heterojunction using lead-free Cs3Bi2Br9 perovskite–modified In4SnS8 for selective photocatalytic CO2 reduction to CO

This study focuses on improving photocatalytic CO2 reduction reaction (CRR) activity and modulating product selectivity. An In4SnS8/Cs3Bi2Br9-X (ISS/CBB-X) heterojunction is prepared using novel lead-free Cs3Bi2Br9 perovskite quantum dot–modified In4SnS8, which shows considerable potential as photocatalysts for CRRs under visible light. The optimised ISS/CBB photocatalyst exhibits high activity an

Effects of swirler blade angle and actuator applied voltage on combustion characteristics and cooling effectiveness

This paper investigated effects of swirlers with blade angles and applied voltage of plasma actuators on combustion and wall temperature of a Can - type gas turbine combustor. Results show that large blade angle of the swirler is beneficial for the mixing of fuel and air, which improves uniformity of the outlet temperature distribution and reduces CO emission but results in temperature rise of the

Operando Observation of Oxygenated Intermediates during CO Hydrogenation on Rh Single Crystals

The CO hydrogenation reaction over the Rh(111) and (211) surfaces has been investigated operando by X-ray photoelectron spectroscopy at a pressure of 150 mbar. Observations of the resting state of the catalyst give mechanistic insight into the selectivity of Rh for generating ethanol from CO hydrogenation. This study shows that the Rh(111) surface does not dissociate all CO molecules before hydrog

Structure and anisotropic dynamics of stimuli responsive colloidal ellipsoids at the nearest neighbor length scale

Stimuli-responsive self-assembly of (an) isotropic colloids has resulted in a plethora of self-assembled structures with potential applications in fabricating smart materials. A lack of detailed understanding of the interplay between these self-assembled structures and the resulting dynamics has often impeded the exploitation of their full potential. Herein, we have unveiled the relationship betwe

The cobalt oxidation state in preferential CO oxidation on CoOx/Pt(111) investigated by operando X-ray photoemission spectroscopy

The combination of a reducible transition metal oxide and a noble metal such as Pt often leads to active low-temperature catalysts for the preferential oxidation of CO in excess H2 gas (PROX reaction). While CO oxidation has been investigated for such systems in model studies, the added influence of hydrogen gas, representative of PROX, remains less explored. Herein, we use ambient pressure scanni

Uncontrolled asthma predicts severe COVID-19 : a report from the Swedish National Airway Register

Background: Severe asthma increases the risk of severe COVID-19 outcomes such as hospitalization and death. However, more studies are needed to understand the association between asthma and severe COVID-19. Methods: A cohort of 150,430 adult asthma patients were identified in the Swedish National Airway Register (SNAR) from 2013 to December 2020. Data on body mass index, smoking habits, lung funct

Twins in Guinea-Bissau have a 'thin-fat' body composition compared to singletons

The 'thrifty phenotype' hypothesis proposed that fetal undernutrition increases risk of diabetes in later life. Undernourished low birthweight Indian babies are paradoxically more adipose compared to well-nourished European babies, and are at higher risk of diabetes in later life. Twin pregnancies are an example of in utero growth restrictive environment due to shared maternal nutrition. There are

A collaborative planning process to develop future scenarios for wastewater systems

Wastewater infrastructure has a long lifetime and is subject to changing conditions and demands. When plans are made to upgrade or build new infrastructure, transdisciplinary planning processes and a robust analysis of future conditions are needed to make sustainable choices. Here, we provide a stepwise collaborative planning process in which future scenarios are developed together with local stak

Hydrogen sulfide potentiates the protective effects of nitrite against myocardial ischemia-reperfusion injury in type 2 diabetic rats

Decreased heart levels of nitric oxide (NO) and hydrogen sulfide (H2S) in type 2 diabetes (T2D) are associated with a higher risk of mortality following ischemia-reperfusion (IR) injury. This study aimed to determine the effects of co-administration of sodium nitrite and sodium hydrosulfide (NaSH) on IR injury in the isolated heart from rats with T2D. Two-month-old male rats were divided into 5 gr