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Otoacoustic emissions and improved pass/fail separation using wavelet analysis and time windowing

A new method is presented for the purpose of improving pass/fail separation during transient evoked otoacoustic emission (TEOAE) hearing screening. The method combines signal decomposition in scales using the discrete wavelet transform, non-linear denoising and scale-dependent time windowing. The cross-correlation coefficient between two subaveraged, processed TEOAE signals is used as a pass/fail

Discriminatory analysis of biochip-derived protein patterns in CSF and plasma in neurodegenerative diseases

The role of biomarkers in neurodegenerative diseases has been emphasized by recent research. Future clinical demands for identifying diseases at an early stage may render them essential. The aim of this pilot study was to test the analytical performance of two multiplex assays of cerebral markers on a well-defined clinical material consisting of patients with various neurodegenerative diseases. We

Detecting Stochastic Nuclear Quadrupole Resonance Signals in the Presence of Strong Radio Frequency Interference

Nuclear quadrupole resonance (NQR) is a radio frequency (RF) spectroscopic technique, allowing the detection of many high explosives and narcotics. In practice, NQR is restricted by the low signal-to-noise ratio of the observed signals, a problem further exacerbated by the presence of strong RF interference (RFI). The current literature focuses on the use of conventional, multiple-pulsed NQR (cNQR

Disturbed cholesterol homeostasis in hormone-sensitive lipase null mice.

Transcriptomics analysis revealed that genes involved in hepatic de novo cholesterol synthesis were down-regulated in fed HSL-null mice that had been on high-fat diet (HFD) for 6 months. This finding prompted a further analysis of cholesterol metabolism in HSL-null mice, which was performed in fed and 16-h fasted mice on a normal chow diet (ND) or a HFD regimen. Plasma cholesterol was elevated in

Definition of Genetic Events Directing the Development of Distinct Types of Brain Tumors from Postnatal Neural Stem/Progenitor Cells.

Although brain tumors are classified and treated based upon their histology, the molecular factors involved in the development of various tumor types remain unknown. In this study, we show that the type and order of genetic events directs the development of gliomas, central nervous system primitive neuroectodermal tumors, and atypical teratoid/rhabdoid-like tumors from postnatal mouse neural stem/

Prospective study of nosocomial transmission of hepatitis C in a Swedish gastroenterology unit .

A prospective study of incident hepatitis C in 515 gastroenterology patients was conducted by follow-up sampling at 3-6 months after admission to the gastroenterology unit to test for antibodies to hepatitis C virus and for hepatitis C virus RNA. Universal precautions were implemented, and the use of multidose vials had been banned in this unit. Despite 5,964 exposure-days for several risk factors