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Early mitochondrial metabolism and dynamics changes as predictors of neurodegeneration and neuronal cell death

Background: Neuronal calcium and ATP homeostasis is regulated through alterations in mitochondria fusion/fission events and anterograde and retrograde transport in neurons. Mitochondrial dynamics form an interactome that ultimately controls mitochondrial quality, quantity and metabolism. Our objective is to show that alterations in this interactome lead to point-of-no-return situations characteriz

Coherent J / ψ and ψ ′ photoproduction at midrapidity in ultra-peripheral Pb–Pb collisions at √sNN=5.02 TeV

The coherent photoproduction of J/ψ and ψ′ mesons was measured in ultra-peripheral Pb–Pb collisions at a center-of-mass energy sNN−−−√ = 5.02 TeV with the ALICE detector. Charmonia are detected in the central rapidity region for events where the hadronic interactions are strongly suppressed. The J/ψ is reconstructed using the dilepton (l+l−) and proton–antiproton decay channels, while for the ψ′ t

Jet energy scale and resolution measured in proton–proton collisions at √s=13 TeV with the ATLAS detector

Jet energy scale and resolution measurements with their associated uncertainties are reported for jets using 36–81 fb−1 of proton–proton collision data with a centre-of-mass energy of s√=13 TeV collected by the ATLAS detector at the LHC. Jets are reconstructed using two different input types: topo-clusters formed from energy deposits in calorimeter cells, as well as an algorithmic combination of c

Hepatic and extrahepatic insulin clearance in mice with double deletion of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors

The aim of this study was to investigate whether incretins, at physiological levels, affect hepatic and/or extrahepatic insulin clearance. Hepatic and extrahepatic insulin clearance was studied in 31 double incretin receptor knockout (DIRKO) and 45 wild-type (WT) mice, which underwent an Intravenous Glucose Tolerance Test (IVGTT). A novel methodology based on mathematical modeling was designed to

A methodology for the assessment of compound sea level and rainfall impact on urban drainage networks in a coastal city under climate change

This study seeks to investigate how stormwater drainage systems in coastal cities respond to climate change in terms of simultaneous sea level rise and rainfall. 7.5 years of recorded rainfall and sea level data in the city of Trelleborg in Sweden were used to generate projections of future climate events based on the emission scenario RCP8.5. Twelve scenarios were formulated to represent rain and

Optimization of experimental and computational processes to study mitochondrial trafficking and metabolic biomarkers

Background: The complex polarity of neurons requires specialized mechanisms to allocate sufficient number of mitochondria to neurites and synapses to control local calcium and ATP levels. Deficits in trafficking are directly linked to neurodegeneration. Our objective is to demonstrate that alterations of mitochondrial spatial location and metabolism are interconnected and can lead to point-of-no-r

Critical Review of Electro-kinetic Remediation of Contaminated Soils and Sediments : Mechanisms, Performances and Technologies

Remediation of contaminated soil and sediment is important for improving the eco-environmental quality. Electro-kinetic remediation (EKR) is an environmentally friendly technology to migrate and remove pollutants from the soil and sediment matrix. This paper analyses the mechanism and performance of EKR of heavy metals, organic pollutants, and compound pollutants. Moreover, the effect of optimizin

An infrared study of Galactic OH/IR stars - III. Variability properties of the Arecibo sample

We present the results of a near-infrared (NIR) monitoring programme carried out between 1999 and 2005 to determine the variability properties of the 'Arecibo sample of OH/IR stars'. The sample consists of 385 IRAS-selected Asymptotic Giant Branch (AGB) candidates, for which their O-rich chemistry has been proven by the detection of 1612 MHz OH maser emission. The monitoring data were complemented

Astrometric radial velocities for nearby stars

Context. Under certain conditions, stellar radial velocities can be determined from astrometry, without any use of spectroscopy. This enables us to identify phenomena, other than the Doppler effect, that are displacing spectral lines. Aims. The change of stellar proper motions over time (perspective acceleration) is used to determine radial velocities from accurate astrometric data, which are now

Elongation rate and average length of amyloid fibrils in solution using isotope-labelled small-angle neutron scattering

We demonstrate a solution method that allows both elongation rate and average fibril length of assembling amyloid fibrils to be estimated. The approach involves acquisition of real-time neutron scattering data during the initial stages of seeded growth, using contrast matched buffer to make the seeds effectively invisible to neutrons. As deuterated monomers add on to the seeds, the labelled growin

Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study

The trace element selenium is of essential importance for the synthesis of a set of redox active proteins. We investigated three complementary serum selenium status biomarkers in relation to overall survival and recurrence following diagnosis of primary invasive breast cancer in a large prospective cohort study. The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a prospective po

Survey on opportunities and barriers in lighting controls

This report summarizes a survey performed in eight countries on the status quo of daylight and electric lighting control systems. Feedback from more than 100 international experts (building / facility managers and planers) was evaluated. The aim of the survey was to identify the perception of the different possibilities of the current lighting control solutions and the expectations about the contr

Ekosystemtjänster och naturnyttor

Vi människor är biologiska varelser och därför sammanvävda med övrigt liv på jorden. Det betyder att vi både för vår överlevnad och för vår vällevnad är helt beroende, inte bara av att det finns en rikedom av liv på planeten, utan också av ett otal ekologiska funktioner som genereras av levande organismer, av enskilda arter eller av flera arter i samspel. Det handlar om direkt livsuppehållande fun