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Cell replacement therapy of neurodegenerative disorders aims to substitute the degenerating cells with new functional neurons. Clinical trails with patients suffering from Parkinson’s or Huntington’s disease have generated proof-of-principle results that neural precursors taken from the developing human brain can survive upon grafting to the diseased brain and provide long-lasting symptomatic reli

Is self-stereotyping part of the stereotype threat process? The self-concepts of 122 male and female business students were assessed by self-report and the Implicit Association Test (Greenwald, McGhee & Schwartz, 1998). The participants were either told that their salary negotiating ability would be assessed (stereotype threat) or not. There were no sex-differences in the non-diagnostic condit

Abstract is available

We investigate theoretically the properties of the photon state and the electronic transport in a system consisting of a metallic quantum dot strongly coupled to a superconducting microwave transmission line cavity. Within the framework of circuit quantum electrodynamics, we derive a Hamiltonian for arbitrary strong capacitive coupling between the dot and the cavity. The dynamics of the system is

Background Few authors have investigated function and pain after surgical treatment of patients with bone metastases. In 1999 the Scandinavian Sarcoma Group (SSG) initiated the Skeletal Metastasis Registry as a multi-centric, prospective study to provide a scientific basis for recommendations of treatment. Patients and methods We have analyzed function and pain in 530 patients (mean age 65 yr) ope

Background: Continuous abstinence and retention in treatment for alcohol and drug use disorders are central challenges for the treatment providers. The literature has failed to show consistent, strong predictors of retention. Predictors and treatment structure may differ across treatment modalities. In this study the structure was reinforced by the addition of supervised urine samples three times

Projektet Framgångspotential är en kartläggning av vissa professionella attityder och personliga egenskaper hos 2000-talets bibliotekarier. Kartläggningen gjordes 2001-2002. Den övergripande forskningsfrågan rör hurdana medarbetare biblioteken behöver under de kommande 10-20 åren. Projektet syftade till att med utgångspunkt från en lista över 34 personliga egenskaper kartlägga och analysera dels a

Popular Abstract in German Bakterielle Infektionen gehören zu den häufigsten Todesursachen weltweit. Sepsis ist definiert durch das Vorhandesein einer Infektion, sowie der Erfüllung von 2 der 4 Kriterien eines systemischen Entzündungssyndroms. Die durch die Bakterien ausgelöste Immunantwort umfasst die Aktivierung der zellulären Immmunität, der Gerinnerungs- und Komplementsysteme, sowie die ProdukBacterial infections and sepsis are amongst the leading causes of death worldwide. Sepsis is caused by an uncontrolled systemic host response towards an invading pathogen. Due to the engagement of various systems including cellmediated responses, the coagulation and complement cascades, treatment of sepsis remains challenging. This is reflected in mortality rates of about 50 % for patients with se

Cathepsin E (CTSE), an aspartic proteinase, is differentially expressed in the metaplasia-dysplasia-neoplasia sequence of gastric and colon cancer. We evaluated CTSE in Barrett's esophagus (BE) and cancer because increased CTSE levels are linked to improved survival in several cancers, and other cathepsins are up-regulated in BE and esophageal adenocarcinoma (EAC). A total of 273 pretreatment tiss

Popular Abstract in Swedish Depression är en av de stora folksjukdomarna och drabbar varannan kvinna och var fjärde man någon gång under deras livstid. Vid djupa depressioner, då självmordsrisken är hög eller då patienten hamnat i ett livshotande tillstånd på grund av oförmåga att äta och dricka används elektrokonvulsiv terapi (ECT), eller som det ofta kallas, ”elbehandling”. Ungefär 45 000 patienElectroconvulsive therapy (ECT) is a well-established treatment for severe depressive disorder, but its clinical use has been limited by concerns about side effects such as memory disturbances. Despite over 70 years in clinical use, the exact mechanisms of action behind the therapeutic or adverse effects are not fully understood. Enhanced brain plasticity, including neurogenesis, angiogenesis and

In elderly man, low serum 25-hydroxyvitamin D (25(OH)D) was associated with a substantial excess risk of death compared to 25(OH)D values greater than 50-70 nmol/l, but the association attenuated with time. The aim of the present study was to determine whether poor vitamin D status was associated with an increase in the risk of death in elderly men. We studied the relationship between serum 25(OH)

Recension av två doktorsavhandlingar.This review scrutinizes two doctoral dissertations at Lund University, one in Historical Archaeology, the other in Latin. Both are deemed to deserve high praise.

Topology optimization at finite strain setting using the concept of inverse motion based form finding is introduced. This novel procedure allows boundary conditions and shape of the structure in the operating, deformed, state to be prescribed. The outcome of the optimization algorithm will be the shape of the undeformed structure, i.e. the state in which the structure should be manufactured. The o

In the 1990s, several public corruption scandals were uncovered in Sweden. This article focuses specifically on local corruption, and our purpose is to examine whether a case can be made that problems of public corruption in Swedish municipalities have increased. By applying instruments from the institutional rational choice framework, we reach the conclusion that there are indeed reasons to suspe

The fact that 10% of female mice enter oestrus and allow mating in the middle of the day is an old observation that has been more or less forgotten. We here show that this old knowledge can be used to improve the efficacy of both embryo transfer and insemination protocols. The present technical paper shows that rapid re-arrangements of mating cages, to achieve pseudo-pregnant recipients in the mid

Herein we investigated the association between polymorphisms in the LRP5 gene and bone phenotypes and fractures in three large male cohorts based on the rationale that mutations in LRP5 cause severe bone phenotypes. Results showed an association of the Val667Met SNP with spine BMD in 3,800 young and elderly men. INTRODUCTION: The low-density lipoprotein receptor-related protein 5 (LRP5)-Wnt signal

OBJECTIVE-Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes. The objective was to determine whether SNAP23 may also be involved in the known association between lipid accumulation in skeletal muscle and insulin resistance/type 2 diabetes in humans, as

We consider model predictive control (MPC) problems with linear dynamics, polytopic constraints, and quadratic objective. The resulting optimization problem is solved by applying an accelerated gradient method to the dual problem. The focus of this paper is to provide bounds on the number of iterations needed in the algorithm to guarantee a prespecified accuracy of the dual function value and the