Plasma phosphorylated tau181 (P-tau181) might be increased in Alzheimer’s disease (AD), but its usefulness for differential diagnosis and prognosis is unclear. We studied plasma P-tau181 in three cohorts, with a total of 589 individuals, including cognitively unimpaired participants and patients with mild cognitive impairment (MCI), AD dementia and non-AD neurodegenerative diseases. Plasma P-tau18

Sign languages do not arise from thin air: rather, they emerge in communities where conventions are already in place for using gesture. Little research has considered how these conventions are retained and/or adapted as gestures are integrated into emerging sign language lexicons. Here we describe a set of five gestures that are used to convey negative meanings by both speakers and signers in a si

On the morning of the 8th of April 2013, the world woke up to Abu Bakr Al- Baghdadi, the leader of what was called the Islamic State in Iraq or ISI, announcing the expansion of his group from Iraq into Syria. Al-Baghdadi also announced the merger of ISI and Jabhat al-Nusra (JN) into a new group called the Islamic State in Iraq and al-Sham or ISIS. Only one day after the announcement, JN released a

In this conceptual paper theory of infrastructure is combined with one of situated learning, with a focus on search and search engines. The aim of the paper is to make a theoretical contribution to the information literacy research field by discussing theoretical contradictions as well as strengths when combining the two theoretical perspectives. Search engines and their use are part of the contem

This article describes the types of signed names given and used by deaf users of Japanese Sign Language. Drawing from a dataset of 216 signed names, we identify and describe nine strategies for signed name formation. Notably, seven of these represent written Japanese surnames. We explain how language contact with written Japanese characters (kanji) and syllabograms (kana) gives rise to a distincti

α-Synucleinopathies are characterized by autonomic dysfunction and motor impairments. In the pure autonomic failure (PAF), α-synuclein (α-Syn) pathology is confined within the autonomic nervous system with no motor features, but mouse models recapitulating PAF without motor dysfunction are lacking. Here, we show that in TgM83+/− mice, inoculation of α-Syn preformed fibrils (PFFs) into the stellate

This paper reports a study of pupils’ experiences of media and information literacy education in five Swedish schools by answering the following overarching question, what roles do the teaching of information seeking and critical assessment of information play for pupils in their school-work as well as in their everyday life? Pupils in ninth grade were asked to fill in a questionnaire regarding th

The article gives an overview of erectile mechanisms and erectile dysfunction (ED). Current treatment of ED is presented. Most of the patients with ED should be treated by their primary care physician. Urologists should be involved only when treatment has failed, and when erectile implants might be an option. In Skåne the waiting list for these patients has been eliminated by using the operating c

Social learning is often treated as an intervention, a designed process facilitated or even initiated by a third party. We investigated how a social learning process emerged spontaneously from inside Kristianstad, one of the most flood-prone municipalities in Sweden. Twenty key persons were interviewed over 8 years, many of them several times, to assess the process. A small action oriented group o

Objectives To investigate changes in bone mineral density (BMD) in patients with early rheumatoid arthritis (RA) over a 10-year period. Methods Consecutive patients with early RA (symptom duration

In this study, we aim to investigate the possibility that the construction of the Isahaya Sea-Dyke significantly causes anoxic water development in the bottom layer in the Ariake Sea, Japan. We numerically compared the vertical distribution of dissolved oxygen (DO) in the water column between two cases with the dyke and without it. As a result of this research, the followings are clarified: 1) DO

This study investigated how a history of menopausal hormone therapy (MHT) impacts clinical outcomes overall and in different subgroups of breast cancer patients. The study included 814 primary breast cancer patients aged ≥50 years in Sweden (2002–2012) with follow-up until 2016. Associations between patient- and tumor characteristics, recurrences, and overall survival were analyzed in relation to

Bioengineered polyhydroxyalkanoate (PHA) spheres assembled in engineered bacteria are showing promising potential in protein immobilization for high-value applications. Here, we have designed innovative streamlined approaches to add functional proteins from complex mixtures (e.g., without prior purification) to bioengineered PHA spheres directly harnessing the specificity of the SpyTag/SpyCatcher