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Inter- and intraindividual pharmacokinetic variations of mirtazapine and its N-demethyl metabolite in patients treated for major depressive disorder - A 6-month therapeutic drug monitoring study

Mirtazapine pharmacokinctic (PK) data from patients on long-term treatment for major depression have never been investigated. For this reason, in a large naturalistic outpatient study (prospective, multicenter, open-labeled, and noncomparative) conducted in Sweden in the period 2000 2002, one of the main objectives was to outline the inter- as well as intraindividual PK variance of mirtazapine and

Interarrival times in a counting process and bird watching

We determine simple approximate relations between the distributions of the interarrival times and the total time of a stopped counting pro- cess, under the assumption of small intensities. These relations sug- gest applying recent results for nonparametric estimation of monotone and convex densities. The results are applied to estimating the distri- bution of the period of stay of migrating birds.

The spatial organization of the news industry: Questioning assumptions about knowledge externalities for clustering of creative industries

The importance ascribed to knowledge externalities for understanding the spatial organization of industries (i.e. clustering) is increasingly being exposed to critical theoretical and empirical scrutiny. This research has not yet spilled over into studies of creative industries. This paper is concerned with reducing this omission by making an empirically based assessment of the importance of respe

Parallelization of a multi-blocked CFD code via three strategies for fluid flow and heat transfer analysis

This paper reports on a parallel implementation of a general 3D multi-block CFD code. The parallelization is achieved by using three strategies. Firstly, it is done on dual-processor PC-clusters where Windows NT systems are running. A multi-thread programming model is adopted for the multi-block code, where one thread corresponds to a block. Shared-memory is used for the exchange of inner-boundari

From cure to palliation: concept, decision and acceptance

The aim of this paper is to present and discuss nurses' and physicians' comments in a questionnaire relating to patients' transition from curative treatment to palliative care. The four-page questionnaire relating to experiences of and attitudes towards communication, decision-making, documentation and responsibility of nurses and physicians and towards the competence of patients was developed and

Imaging of cervico-thoracic lymphangiomas in children

This study was undertaken to define the role of ultrasound (US) and magnetic resonance (MR) imaging in the diagnosis and preoperative staging of cervico-thoracic lymphangiomas in children. In a retrospective study, 11 patients with surgically and pathologically proved lymphangiomas had MR imaging and 6 of them underwent simultaneous US. US showed superficial hypoechogenic multioccular cystic masse

On the effects of spin-orbit coupling on molecular properties: Dipole moment and polarizability of PbO and spectroscopic constants for the ground and excited states

The lower electronic states of the molecule PbO have been studied using a newly developed basis set of the atomic natural orbital (ANO) type. The method includes scalar relativistic effects through the use of a Douglas-Kroll Hamiltonian. Multiconfigurational wave functions have been used with dynamic correlation included using second-order perturbation theory (CASSCF/CASPT2). Spin-orbit coupling i

Hållbar tillväxt - möjlighet eller motsägelse? En granskning av aktörer och strategier inom EU och Lissabonprocessen

In 2000 the European Council agreed on the so called ‘Lisbon Strategy’, the purpose of which is to make the European Union the strongest and most competitive economy in the world and also to fight unemployment and secure social welfare systems. One year later, in 2001, an ‘environmental dimension’ was supplemented to the Lisbon Strategy at the Council meeting in Gothenburg. An ‘EU Strategy for Sus

Emergence of a Welfare State - Social Insurance in Sweden in the 1910s

Two important dimensions of the Swedish social insurance system are those of universality (encompassing the entire population) and of compensation for loss of income. The decisions basic to the Swedish social insurance system and thus to the Swedish Welfare State were made during the 1910s. A universal pension insurance system was decided upon in 1913. This was the world's first universal public i