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Evaluation of exposure biomarkers from percutaneous absorption of N-methyl-2-pyrrolidone.

OBJECTIVES: The aim of this study was to evaluate different biomarkers of exposure to N-methyl-2-pyrrolidone (NMP), a widely used industrial chemical. For this purpose, differences in toxicokinetics between men and women and between pure and water-mixed NMP were evaluated after dermal absorption. METHODS: Six female and six male volunteers (groups 1 and 2) were topically exposed for 6 hours to 300

Expression of Serotonin Receptors 5-HT1A, 5-HT1B, 5-HT2B and 5-HT4 in Ovary and in Ovarian Tumours.

BACKGROUND: Recently we have shown that serotonin receptors may be involved in prostate cancer development. In ovarian carcinogenesis, oestrogen may play a role. As oestrogen seems to mediate at least some of its biological effects through serotonin, we decided to evaluate if serotonin receptors are expressed in ovary and in ovarian tumours and if the expression is correlated to ovarian tumour dev

Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycan

We report the purification of betaglycan, a low-abundance membrane proteoglycan with high affinity for transforming growth factor-beta (TGF-beta). Betaglycan solubilized from rat embryo membrane preparations was purified to near-homogeneity by sequential chromatography through DEAE-Trisacryl, wheat germ lectin-Sepharose, and TGF-beta 1-agarose. Purified betaglycan has properties similar to betagly

Thermopower anomaly in multiple barrier structures

We have predicted that in suitable multiple barrier structures without applied bias, the thermopower may change sign because of quantum transport process. We have performed detailed numerical calculation to show that the predicted thermopower anomaly can be experimentally observed. This thermopower anomaly does not violate thermodynamic laws.

Some Integral Formulas for Fatigue Damage in Variable Amplitude Loading

In this paper some integral formulas for the fatigue damage in variable amplitude loading are presented. The formulas, which in their original form appeared in Rychlik (1993), may be used for both the theoretical analysis of the fatigue damage, resulting from different cycle counting algorithms, as well as for the computation of different statistical properties of the fatigue damage.

Det sociala spelet om Romano Platso

This thesis has been taking a starting point from a micro-level that focuses social structures, ethnic segregation and processes of development as phenomena from different levels of perspectives. The research focuses on housing-conditions in the urban room and take a starting-point in 1992 when an increased number of immigrant households, depending on social welfare, moved into Herrgården (Manor-H

Resistance to fluoroquinolones in Pseudomonas aeruginosa and Klebsiella pneumoniae

The fluoroquinolone sensitivity of Pseudomonas aeruginosa and Klebsiella pneumoniae was studied by determinations of Minimum Inhibitory Concentrations (MICs) of norfloxacin and ciprofloxacin in consecutive clinical isolates. In P. aeruginosa, resistance or reduced susceptibility (MIC > or = 8 mg/l for norfloxacin and > or = 2 mg/l for ciprofloxacin) was found in 17% (9/54) of the isolates. Reduced

Combining sequence-specific probes and DNA binding dyes in real-time PCR for specific nucleic acid quantification and melting curve analysis

Currently, in real-time PCR, one often has to choose between using a sequence-specific probe and a nonspecific double-stranded DNA (dsDNA) binding dye for the detection of amplified DNA products. The sequence-specific probe has tire advantage that it only detects the targeted product, while the nonspecific dye has the advantage that melting curve analysis can be performed after completed amplifcat

Lamperti Transform and a Series Decomposition of Fractional Brownian Motion

The Lamperti transformation of a self-similar process is a strictly stationary process. In particular, the fractional Brownian motion transforms to the second order stationary Gaussian process. This process is represented as a series of independent processes. The terms of this series are Ornstein-Uhlenbeck processes if $H1/2$. From the representation effective approximations of the process are der

Naturlighetens positioner. Nordiska kulturforskare om födsel och föräldraskap

Denna bok handlar om naturlighet iförhållande till födsel och föräldraskap - om hur naturligheten positioneras i människans föreställningar kring födseln. Under de tio-femton senaste åren har det skett en förändring i dessa föreställningar från en högteknologisk omsorg med hög riskmedvetenhet till en mer naturlig eller alternativ omsorg. Där tidigare det medicinska tänkandet, som innebar att hälso

Degradation of acetonitrile through a sequence of microbial reactors

Degradation of nitrogen containing organic compounds often leads to formation of ammonium and some low molecular weight organic compounds. The study is focused on degradation of acetonitrile in a sequence of stirred biofilm reactors, where the degradation of acetonitrile into acetic acid and ammonia takes place in the first two reactors. A large fraction of the acetic acid is also degraded in thes

Effects of E-selectin and P-selectin blockade on neutrophil sequestration in tissues and neutrophil oxidative burst in burned rats

OBJECTIVE: Neutrophil deposition in tissues (leukosequestration) after shock may produce local tissue injury from proteases and high-energy oxygen species released from sequestered neutrophils. The initial step in the binding of neutrophils to capillary endothelium is the interaction of adhesion molecule (selectin) receptors between neutrophils and endothelial cells. We quantified leukosequestrati

Palaeomagnetism of Eocene Talerua Member lavas on Hareoen, West Greenland

The results of a paleomagnetic sampling carried out along two vertical profiles (altogether 19 lava flows, 126 samples) covering the entire stratigraphy of the Talerua Member lavas (similar to 39 Myr old) that outcrop on the island Hareoen are presented and represent some of the youngest volcanism in the West Greenland flood volcanic province. Rock magnetic experiments and microprobe analysis demo