It is unclear whether the distribution of tau pathology differs between cases with early-onset familial Alzheimer's disease (AD) and sporadic AD. We present positron emission tomography (PET) data from a young patient with a presenilin-1 mutation (Thr116Asn). 18F-flutemetamol PET showed a distribution of amyloid-β fibrils similar to sporadic AD. However, the pattern of tau pathology, revealed usin

Objective: Catheter-associated urinary tract infection (CAUTI) is the most common healthcare-associated infection. The primary aim of this study was to investigate whether the use of a silicone catheter coated with an ultrathin layer of a combination of the noble metals gold, palladium and silver (BIP™–silicone catheter) could reduce the incidence of CAUTI and antibiotic prescription compared with

A major issue in Irish economic history is the lack of historical national accounts before the interwar period. This paper addresses the gap with new annual estimates of real GDP between 1842 and 1913 using an indirect estimation technique based on a set of macroeconomic variables and a dynamic factor model. Three major results emerge from the data. First, per capita growth was faster in this peri

Recent developments in Knowledge Sharing (KS) have heightened the need for security. However, there has been little discussion about ‘how to’ integrate security into KS models effectively. This research addresses this gap by proposing a KS Risk Governance (KSRG) framework and research model based on the framework to integrate security into KS through Knowledge Risk Governance (KRG). The role of KR

The paper explores gender relations and gender identity, based upon an ethnography of a Swedish advertising agency. The organization is of special interest as it has a strong gender division of labor, where men hold all senior posts, at the same time as creative advertising work seems to have much more similarity with what gender studies describe as "femininity" rather than with forms of "masculin

We present the discovery of the first Neptune analog exoplanet or super-Earth with a Neptune-like orbit, MOA-2013-BLG-605Lb. This planet has a mass similar to that of Neptune or a super-Earth and it orbits at 9 ∼ 14 times the expected position of the snow line, a snow, which is similar to Neptune's separation of 11 a snow from the Sun. The planet/host-star mass ratio is q = (3.6 ± 0.7) × 10-4 and

We study the thermodynamic behavior of a model protein with 54 amino acids that forms a three-helix bundle in its native state. The model contains three types of amino acids and five to six atoms per amino acid and has the Ramachandran torsional angles phi(i), psi(i) as its degrees of freedom. The force field is based on hydrogen bonds and effective hydrophobicity forces. For a suitable choice of

Background/Objective: A biphasic ceramic bone substitute consisting of calcium sulfate and hydroxyapatite has been reported to give good clinical outcome regarding bone regeneration and may serve as a carrier for antibiotics in the treatment of bone infections. Often, the overlying muscle is in direct contact with the synthetic graft. The dissolving bone substitute induces inflammation, which may

Julia Brinck (1854–1926) är den första svenska kvinnan med europeisk läkarutbildning i modern tid. Hon föddes i Helsingborg och tog sjukgymnastiskexamen i Stockholm vid 21 års ålder. Därefter arbetade hon på flera gymnastiska institut i Europa innan hon blev läkare 1886, efter fyra års studier i London. Julia Brinck var också en av de första svenska kvinnorna som ägnade sig åt naturvetenskaplig fo

In blind source separation (BSS), multiple mixtures acquired by an array of sensors are processed in order to recover the initial multiple source signals. While a variety of Independent Component Analysis (ICA)-based techniques are being used, in this paper we used a newly proposed method: The Degenerate Unmixing and Estimation Technique (DUET). The method applies when sources are W-disjoint ortho

Subband adaptive filters have been proposed to speed up the convergence and to lower the computational complexity of time domain adaptive filters. However, subband processing causes signal degradations due to aliasing effects and amplitude distortions. This problem is unavoidable due to further filtering operations in subbands. In this paper, the problem of aliasing effect and amplitude distortion

The Gaia-ESO Survey was designed to target all major Galactic components (i.e. bulge, thin and thick discs, halo and clusters), with the goal of constraining the chemical and dynamical evolution of the Milky Way. This paper presents the methodology and considerations that drive the selection of the targeted, allocated and successfully observed Milky Way field stars. The detailed understanding of t