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The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males

Herein, we examined insulin resistance (IR), insulin sensitivity (IS), beta cell activity, and glucose metabolism in subjects with antisocial personality disorder (ASPD), and whether the serotonin 2B (5-HT2B) receptor and testosterone have a role in energy metabolism. A cohort of subjects belonging to a founder population that included 98 ASPD males, aged 25–30, was divided into groups based on th

Barriers to continuity in the pathway toward occupational engagement among ethnic minorities with mental illness

Ethnic minorities have particular needs and difficulties in terms of support for meaningful occupations, lack of access to and use of occupation-based rehabilitation services. They are not established in the labour market and are seldom in paid employment. This study aimed to investigate how mentally ill ethnic minority clients experience, feel and think about participation in occupation-based reh

Agent of change : street art and environmental thinking

This paper applied an ecocritical perspective on street art to expand on the notion that street art can have an impact on how we relate to urban public space. In doing so, it argued that street art is particularly well positioned to affect the way we think and act with regard to the environment.

Polyhedral Lyapunov functions for structural stability of biochemical systems in concentration and reaction coordinates

Structural properties, independent of specific parameter values, can explain the robustness of biochemical systems. In this paper we consider the framework previously proposed by the authors to assess structural stability of biochemical reaction networks with monotone reaction rates, which considers systems in concentration coordinates, and we show that the results can be applied to systems in rea

Determining the structural properties of a class of biological models

A property for a class of systems is said to be structural if it is met by any system in the class regardless of the adopted parameters. In this paper we investigate the structural nature of oscillatory behaviors, adaptation and monotonicity in a class of sign-invariant systems, capturing a wide variety of biological models. We employ standard robustness analysis tools, suitably tailored to the ca

Selection of antibodies for intracellular function using a two-hybrid in vivo system

Expression of antibodies inside cells has been used successfully to ablate protein function. This finding suggests that the technology should have an impact on disease treatment and in functional genomics where proteins of unknown function are predicted from genomic sequences. A major hindrance is the paucity of antibodies that function in eukaryotic cells, presumably because the antibodies fold i

Drell-Yan phenomenology in the color dipole picture revisited

An extensive phenomenological study of the Drell-Yan (DY) process in pp collisions at various energies is performed in the color dipole framework. Besides previously studied γ∗ production we also include the Z0 contribution relevant at large dilepton invariant masses. We investigate the DY cross section differential in invariant mass, rapidity and transverse momentum of the dilepton pair in pp col

MOTIVATION FATIGUE AS A THREAT to INNOVATION : BYPASSING the PRODUCTIVITY DILEMMA in R&D by CYCLIC PRODUCTION

What do employees need in order to be innovative? In this paper, we explored how employees with different lengths of tenure within the research and development (R&D) department of a company in the automotive industry answer this question. We found that the needs vary depending on the length of the employee's tenure. New employees view innovation as an organisational work issue and employees wi

Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-β delineate two distinct groups of children with brain tumors

Background: Primary brain tumors are the most common solid tumors in children. Increasing evidence demonstrates diverse intratumoral immune signatures, which are tentatively reflected in peripheral blood. Procedure: Twenty cytokines were analyzed in preoperative plasma samples from five healthy children and 45 children with brain tumors, using a multiplex platform (MesoScale Discovery V-PLEX®). Tu

Measurement error in income and schooling, and the bias of linear estimators

We propose a general framework for determining the extent of measurement error bias in OLS and IV estimators of linear models, while allowing for measurement error in the validation source. We apply this method by validating Survey of Health, Ageing and Retirement in Europe (SHARE) data with Danish administrative registers.Contrary to most validation studies, we find measurement error in income is

Nickel-doped agarose gel phantoms in MR imaging

A method for the production of a tissue-mimicking phantom material for MR imaging is described. The material consists of a nickel-doped agarose gel. The T1 and T2 values of the gel can be varied independently by changing the relative amounts of nickel and agarose. Practically any T1 and T2 combination of clinical interest can be obtained. The long-term stability was studied and found to be good. T

Direction of Arrival Estimation for Speech Sources using Fourth Order Cross Cumulant

In many applications where speech separation and enhancement is of interest, e.g. conferencing systems, mobile phones and hearing aids, accurate speaker localization is important. This paper presents an alternative criteria for the well known steered response power with phase transform (SRP-PHAT) algorithm, in which the steered response relates to peaks in the fourth order cross cumulant, rather t

Optimal design of silicon-based chips for piezo-induced ultrasound resonances in embedded microchannels

We present a variational formulation of the governing equations and introduce global indicators to describe the behavior of acoustofluidic devices driven at resonance frequencies by means of a piezoelectric transducer. The individuation of the correct Lagrangian densities for the different parts constituting the device (the piezo transducer, the silicon walls, the fluid-filled microchannel, and th

Translating public diplomacy and nation branding in Scandinavia : An institutional approach to the Cartoon Crises

Nation branding has been criticised for leading to the homogenisation and depoliticisation of national interest and identity. This study examines the politics of nation branding in relation to its configuration with public diplomacy and the institutional policy context in which they are embedded. Informed by Scandinavian institutionalism and the analytical concept of translation, the study reveals