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Hormonal regulation of phosphodiesterase 3B in adipocytes

Popular Abstract in Swedish I min avhandling har jag undersökt hur fosfodiesteras 3B (PDE3B) i fettväven styrs vid svar på två typer av hormoner nämligen, insulin och katekolaminer. Det senare innefattar hormoner så som adrenalin och nor-adrenalin. Varför är då detta intressant att veta? I Sverige och världen har mängden människor med fetma under de senaste åren ökat lavinartat, vilket är en stor Insulin induced activation of the cAMP degrading enzyme phosphodiesterase (PDE) 3B in adipocytes is important for insulin mediated inhibition of lipolysis. The aim of this thesis was to contribute with knowledge on the acute activation of PDE3B in response to insulin and catecholamines in adipocytes. The activation of PDE3B was investigated from three different perspectives namely; phosphorylation

Integrated life cycle design : application to concrete multi-dwelling buildings

This work examines the application of ILCD (Integrated Life Cycle Design), to Swedish concrete multi-dwelling buildings. The aim of the study is to look into methodological issues of ILCD and to present the fundamental attributes of dwelling buildings and how they relate to concrete as a structural material. Methods for prediction of two important life cycle attributes: the economy and energy use

Ökat intresse för monument

Recension av Carl Felding; Nordens ryttarstatyer, Bengt Järbe, Krigens och minnesmärkens Stockholm i skulpturer och minnesstenar samt Bengt Järbe & Gösta Glase, Stockholms statyer.

A comparative study of two methods for determination of pH, exchangeable base cations, and aluminum

The ability to compare soil chemical data achieved by different chemical extraction methods is a necessity for an efficient long-term monitoring of soils and for comparisons of results from regional soil surveys with differing standard methods. This study compares two common, methods for analysis of soil chemical properties, the combination of soil extraction in 1.0 M NH4Cl and 1.0 M KCl and the s

Deliberate self-harm in 15-year-old adolescents: A pilot study with a modified version of the Deliberate Self-Harm Inventory

The purpose of the present study was to investigate the rate of deliberate self-harm in 15-year-old Swedish adolescents, gender differences in this behavior, and possible associations with self-esteem and mindfulness. For this purpose, we developed a simplified version of Gratz's (2001) Deliberate Self-Harm Inventory (DSHI), and carried out a pilot study with 123 adolescents from three different s

Individual factors affecting stabilometry and one-leg hop test in 75 healthy subjects, aged 15-44 years

The aims of this study were: 1) to investigate whether single-limb stabilometry and a one-leg hop test are influenced by age, sex, height, weight or activity level in healthy subjects, 2) to examine possible differences between the right and the left leg, 3) to determine Limb Symmetry Index (LSI) values, and 4) to study the relation between the stabilometric variables, that is, average speed (AS)

In-field monitoring of cleaning efficiency in waste water treatment plants using two phenol-sensitive biosensors

Two amperometric biosensors based on the enzymes cellobiose dehydrogenase (CDH) and quinoprotein-dependent glucose dehydrogenase (GDH), have been applied for monitoring the phenolic content in water samples, collected at different stages of a waste water treatment process, thus representing different cleaning levels of two waste water treatment plants (WWTPs). The biosensor measurements were perfo

Reconstruction of 3D-Curves from 2D-Images Using Affine Shape Methods for Curves

In this paper, we propose an algorithm for doing reconstruction of general 3D-curves from a number of 2D-images taken by uncalibrated cameras. No point correspondences between the images are assumed. The curve and the view points are uniquely reconstructed, modulo common projective transformations and the point correspondence problem is solved. Furthermore, the algorithm is independent of the choi

On Homogeneous Density Functions

We consider homogeneous density functions for proving almost globalattractivity of the zero equilibrium in a homogeneous system. It is shownthat the existence of such a function is guaranteed whenthe equilibrium is asymptotically stable, or in the more general case, whenthere exists a nonhomogeneous density function for the same systemsatisfying some reasonable conditions. Results related to robus

Clinical tests on impairment level related to low back pain: A study of test reliability

The objectives of the study were, in a working population, to standardize and evaluate a set of clinical tests on impairment level related to the low back with reference to intra- and inter-rater reliability. The study was undertaken in two steps. In step 1, 15 tests were examined for inter-rater reliability by three pairs of physiotherapists and for intra-rater reliability by one physiotherapist.

Identification of Csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure

The lack of a conserved tyrosine autophosphorylation site is a unique feature of the C-terminal Src-kinase, Csk, although this protein tyrosine kinase can be autophosphorylated on tyrosine residues in vitro and in bacteria. Here we show that human Csk is tyrosine phosphorylated in HeLa cells treated with sodium pervanadate. Phosphorylation in vivo occurs mainly at Tyr-184 and in vitro mainly at Ty

Standardization of antibody preparations for use in immunogenicity studies: a case study using the World Health Organization International Collaborative Study for Islet Cell Antibodies.

The immunogenicity of biological therapeutic products is currently a high profile regulatory and biotechnology industry issue. The immune responses raised against biotechnology products range from the benign, to affecting product efficacy, to those that have serious deleterious clinical impact. The most widely used marker of immunogenicity is the detection and measurement of antibody responses ind