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Intraductal papillary neoplasms of the bile ducts : a comparative study of a rare disease in Europe and Nagoya, Japan

Background: Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB. Methods: A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 an

Temperature dependent energy transfer to Eu3+ emission centres in K5Eu(MoO4)4 crystals

Luminescence properties of a palmierite-type K5Eu(MoO4)4 crystal were studied in a wide temperature range of 7-650 K. Eu3+ ions are shown to occupy at least three non-equivalent positions in the palmierite-type structure, forming emission centres with slightly different characteristics due to an incommensurate modulated disordering. The relative intensity of the Eu3+ emission bands originating fro

Integrative species delimitation and biogeography of the Rhinella margaritifera species group (Amphibia, Anura, Bufonidae) suggest an intense diversification throughout Amazonia during the last 10 million years

The accumulation of studies delimiting species in Amazonia has not only shed light on the patterns of its outstanding species richness but also allowed a better understanding of the processes of diversification within this immense region. Nevertheless, vast knowledge gaps remain even for prominent anuran species complexes, such as the Rhinella margaritifera species group. This clade of toads compr

Nanoplastics in aquatic environments—Sources, sampling techniques, and identification methods

Since the industrial revolution, humans have extensively been contributing to the accumulation of rubble in marine and freshwater ecosystems. Because the buildup of trash in water bodies was previously considered miniscule owing to its capacity to drift away from vantage points, the growing impact of plastic pollutants has historically been neglected. Today, however, pollution of aquatic systems i

Validation of the Super-Brief Pathological Narcissism Inventory (SB-PNI) among Swedish adolescents

This study examines the psychometric structure and properties of the Swedish version of the Super-Brief Pathological Narcissism Inventory (SB-PNI) among adolescents. In order to ensure the validity and feasibility of the measure, we examined the factor structure, measurement invariance across gender, age and ethnicity, and construct validity in relation to a number of correlates of narcissism in a

Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity

The diverse gut microbiota, which is associated with mucosal health and general wellbeing, maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including sustainment of germinal centers in a context of high antigenic load. This influences the rules for B cell engagement with antigen and the potential consequences. Recent data have highlighted differences between GALT

The Quality of the Craft

In this study the sustainability of crucibles used during the Scandinavian Bronze Age is tested. Due to the crucible’s high or low sustainability the idea of it being a disposable object may be ratified or discarded. Earlier experiments focusing on the casting process in Scandinavian Bronze Age have concluded that crucibles such as the ones used during Bronze Age were disposable objects due to low

Characterization of airborne dust emissions from three types of crushed multi-walled carbon nanotube-enhanced concretes

Dispersing Multi-Walled Carbon Nanotubes (MWCNTs) into concrete at low (<1 wt% in cement) concentrations may improve concrete performance and properties and provide enhanced functionalities. When MWCNT-enhanced concrete is fragmented during remodelling or demolition, the stiff, fibrous and carcinogenic MWCNTs will, however, also be part of the respirable particulate matter released in the process.

Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independence

Advanced breast cancers represent a major therapeutic challenge due to their refractoriness to treatment. Cancer-associated fibroblasts (CAFs) are the most abundant constituents of the tumor microenvironment and have been linked to most hallmarks of cancer. However, the influence of CAFs on therapeutic outcome remains largely unchartered. Here, we reveal that spatial coincidence of abundant CAF in

Exposure to Paracetamol in Early Pregnancy and the Risk of Developing Cerebral Palsy : A Case-Control Study Using Serum Samples

OBJECTIVE: To investigate whether maternal paracetamol use in early pregnancy is associated with cerebral palsy (CP) in offspring.STUDY DESIGN: We conducted a registry and biobank-based case-control study with mother-child pairs. We identified CP cases (n=322) born between 1995-2014 from a nationwide CP-registry. Randomly selected controls (n=343) and extra preterm controls (n=258) were obtained f