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To investigate epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism (CT8M) as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient; this circumvents any bias introduced by using cells from unrelated, healthy individuals as controls. We profiled gene and miRNA expression as well as genome-wide and promoter
Problem: Niche co-evolution deals simultaneously with the number and the character of species within a community. How can a community of predators and prey adaptively radiate to fill available niches? How many niches are there? And, can adaptive speciation at evolutionary branching points successfully fill the niches of the ESS? Model features: We use a predator–prey model with one fitness-genera
Abstract in UndeterminedInconel 718, an efficient superalloy for energy and aerospace applications, is currently machined with cemented carbide tools at low speed (vc≈60 m/min) due to its unfavorable mechanical and thermal properties. The article presents results of a study of superalloy machinability with whisker reinforced alumina, uncoated and coated PCBN tools. Turning of age hardened Inconel
Protein S functions as a cofactor for tissue factor pathway inhibitor (TFPI) and activated protein C (APC). The sex hormone binding globulin (SHBG)-like region of protein S, consisting of two laminin G-like domains (LG1 and LG2), contains the binding site for C4b-binding protein (C4BP) and TFPI. Furthermore, the LG-domains are essential for the TFPI-cofactor function and for expression of full APC
An integrated system for the production of hydrogen by gasification of biomass and electrolysis of water has been designed and cost estimated. The electrolyser provides part of the hydrogen product as well as the oxygen required for the oxygen blown gasifier. The production cost was estimated to 39 SEK/kg H-2 at an annual production rate of 15 000 ton, assuming 10% interest rate and an economic li
More than a decade ago we published a calculation of nuclear ground-state masses and deformations in Atomic Data and Nuclear Data Tables [P. Moller, J.R. Nix, W.D. Myers, W.J. Swiatecki, At. Data Nucl. Data Tables 59 (1995) 185]. In this study, triaxial nuclear shapes were not considered. We have now enhanced our model and studied the influence of triaxial shape degrees of freedom on the nuclear g
We report the clinical feasibility of fluoroscopic Roentgen stereophotogrammetric analysis (FRSA), a validated method to quantify, real time three-dimensional (3D) dynamic motion of stent grafts and the first clinical results after abdominal and thoracic endovascular repair (EVAR). Stent graft motion was measured at 30 (stereo) frames per second, during the cardiac cycle and in the patient after a
Objective To determine coverage and generalisability of data in the Swedish Biologics Register ARTIS. Methods Patients with adult onset rheumatoid arthritis (RA) were identified in the National Patient Register and the Swedish Rheumatology Quality Register, including the ARTIS cohort of patients exposed to biological agents. Exposure to etanercept and adalimumab between 2006 and 2008 was determine
I den här artikeln argumenterar jag för att vårt tänkande i grunden är metafor- och föreställningsstyrt. Bilder och konceptuella ramverk styr i mångt och mycket hur vi kommunicerar, och därmed i grunden argumenterar och debatterar. Jag hävdar att det finns en utbredd föreställning om att vårt tänkande är mer objektivt förankrat än vad det egentligen är. Som rättssociolog är min poäng att det även
Nystedt recently gave a combinatorial proof of the fact that Ore extensions are associative. As part of it he proves that two sets of strings are identical, using a counting argument. We show that the equality of the sets can be proven directly. (C) 2013 Elsevier B.V. All rights reserved.
Changing Landscapes and Persistent Places is a study of the cultural landscape on the Bjäre peninsula in northwest Skåne. The many Bronze Age remains that give the landscape its distinctive character are the starting point for an attempt to increase our understanding of the historical depth of today’s landscape. The two perspectives of “landscape” and “places” carry the discussion forward, almost
Stable walking depends on the coordination of multiple biomechanical degrees of freedom to ensure the dynamic maintenance of whole-body equilibrium as well as continuous forward progression. We investigated adult age-related differences in whole-body coordination underlying stabilization of center of mass (CoM) position and step pattern during locomotion. Sixteen younger (20-30 years) and 16 healt
Pulsating flow through bifurcations are of general interest. In the human body such flows are also very common; for example in blood vessels and the respiratory tract. The characteristics of the flow in arteries have been related to the process of atherogenesis, based on the observation that the initial manifestation of the process is observed at certain common locations, i.e., near bifurcations i
Popular Abstract in Swedish Skador på skelettet kan uppstå efter bl.a. olyckor, tumörkirurgi eller strålning. Ofta är sådana skador mycket handikappande då de påverkar kroppens funktion, stabilitet och utseende. Om benvävnad saknas eller måste bytas ut använder man sig idag av mikrokirurgiska metoder, där man flyttar kroppseget ben från ett ställe till ett annat. Tyvärr innebär detta att man skapaBone deficiencies, caused by malformations, trauma or adverse effects from medical treatments, are a clinical challenge and often associated with reduced physical function and quality of life. Autologeous bone grafts can be used to reconstruct skeletal defects, but the right size and quality of bone might not always be available and even so, donor-site morbidity might follow. A pre-fabricated or t
We prove a strong comparison theorem in the class ${\cal E}_p(\Omega)$ of certain plurisubharmonic functions with infinite total complex Monge-Amp\`ere masses. We also obtain a convergence theorem in ${\cal E}_p(\Omega)$
L-2,L-3-edge X-ray absorption spectroscopy (XAS) has demonstrated unique capabilities for the analysis of the electronic structure of di-Ru complexes such as the blue dimer cis,cis-[(Ru2O)-O-III(H2O)(2)(bpy)(4)](4+) water oxidation catalyst. Spectra of the blue dimer and the monomeric [Ru(NH3)(6)](3+) model complex show considerably different splitting of the Ru L-2,L-3 absorption edge, which refl
