Mechanistic trade-offs between traits under selection can shape and constrain evolutionary adaptation to environmental stressors. However, our knowledge of the quantitative and qualitative overlap in the molecular machinery among stress tolerance traits is highly restricted by the challenges of comparing and interpreting data between separate studies and laboratories, as well as to extrapolating b

Background/Aims: Male patients with end-stage renal disease suffer from sexual disturbances and infertility. Disturbances in the hypothalamic-pituitary-gonadal axis are one of the causes of this. Decreased testosterone synthesis in Leydig cells of the testes and hyperprolactinemia are common. Kidney transplantation, unlike hemodialysis, normalizes these changes. However, how kidney transplantation

Proton-assisted recoupling (PAR) is examined by exploring optimal experimental conditions and magnetization transfer rates in a variety of biologically relevant nuclear spin-systems, including simple amino acids, model peptides, and two proteins-nanocrystalline protein G (GB1), and importantly amyloid beta 1-42 (M0Aβ1-42) fibrils. A selective PAR protocol, SUBPAR (setting up better proton assisted

P4 ATPase flippases translocate phospholipids across biomembranes, thus contributing to the establishment of transmembrane lipid asymmetry, a feature important for multiple cellular processes. The mechanism by which such phospholipid flipping occurs remains elusive as P4 ATPases transport a giant substrate very different from that of other P-type ATPases such as Na+/K+-and Ca2+-ATPases. Based on a

High-energy surface-sensitive x-ray diffraction (HESXRD) is a powerful high-energy photon technique (E > 70 keV) that has in recent years proven to allow a fast data acquisition for the 3D structure determination of surfaces and nanoparticles under in situ and operando conditions. The use of a large-area detector facilitates the direct collection of nearly distortion-free diffraction patterns over

The theory of turbulent diffusion of chemically reacting gaseous admixtures developed previously [T. Elperin, Phys. Rev. E 90, 053001 (2014)PLEEE81539-375510.1103/PhysRevE.90.053001] is generalized for large yet finite Reynolds numbers and the dependence of turbulent diffusion coefficient on two parameters, the Reynolds number and Damköhler number (which characterizes a ratio of turbulent and reac

This Letter presents the measurement of differential cross sections of isolated prompt photons produced in association with a b-jet or a c-jet. These final states provide sensitivity to the heavy-flavour content of the proton and aspects related to the modelling of heavy-flavour quarks in perturbative QCD. The measurement uses proton–proton collision data at a centre-of-mass energy of 8 TeV record

Ozone was applied to return activated sludge in full-scale to study how ozone impacts filamentous bacteria viability (Live/Dead®). Additionally, the ozonated sludges were subjected to anaerobic digestion trials and analysis of micropollutants. Ozone treatment (3-4.8 g O3/kg TSS) improved the settling properties of the sludge by lowering the diluted sludge volume with 7-35%. Ozone inactivated filamOzone was applied to return activated sludge in full-scale to study how ozone impacts filamentous bacteria viability (Live/Dead®). Additionally, the ozonated sludges were subjected to anaerobic digestion trials and analysis of micropollutants. Ozone treatment (3-4.8 g O3/kg TSS) improved the settling properties of the sludge by lowering the diluted sludge volume with 7-35%. Ozone inactivated filam

Background: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI). Methods: We investigate

Background: Attention-deficit hyperactivity disorder (ADHD) is a common and impairing neurodevelopmental disorder. The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computerized test battery with standardized procedures and solid psychometric properties targeting multiple neuropsychological functions. Aims: The aim of this study was to look at the effects of ADHD on cognitive p

Although legal contexts are subject to biased reasoning and decision making, to identify and test debiasing techniques has largely remained an open task. We report on experimentally deploying the technique “giving reasons pro et contra” with professional (N = 239) and lay judges (N = 372) at Swedish municipal courts. Using a mock legal scenario, participants assessed the relevance of an eyewitnessAlthough legal contexts are subject to biased reasoning and decision making, to identify and test debiasing techniques has largely remained an open task. We report on experimentally deploying the technique “giving reasons pro et contra” with professional (N = 239) and lay judges (N = 372) at Swedish municipal courts. Using a mock legal scenario, participants assessed the relevance of an eyewitness

Patients with mantle cell lymphoma (MCL) usually respond to initial combination chemotherapy, but the disease inevitably relapses and often follows an aggressive course. Here, clinical study results published since 2008 for patients with relapsed/refractory MCL were reviewed to compare available evidence for treatment guidance. Most trials identified were non-randomized, phase II studies performed

A Bayesian assessment of the probability that the defendant in a criminal trial is guilty depends on the presumed base rate for guilt and the estimated likelihoods of the evidence. This article explores how the base rate shall be determined. Bayesian scholars have recommended a base rate of 1/N, where N is the number of ‘possible perpetrators’, but it is unclear how the reference class of possibleA Bayesian assessment of the probability that the defendant in a criminal trial is guilty depends on the presumed base rate for guilt and the estimated likelihoods of the evidence. This article explores how the base rate shall be determined. Bayesian scholars have recommended a base rate of 1/N, where N is the number of ‘possible perpetrators’, but it is unclear how the reference class of possible

Despite numerous recent studies of Italic textiles and textile production etc., no systematic study has so far been attempted regarding the textile terminology of Italic languages besides Latin. The present study seeks to remedy this, making a first step into the textile terminology of Sabellic languages, predominantly Oscan and Umbrian. There are two types of sources for Sabellic textile terminol