Translational regulation of ornithine decarboxylase (ODC), which catalyses the first step in the biosynthesis of polyamines, appears to be an important mechanism in the strong feedback control as well as in the hypotonic induction of the enzyme. However, the exact mechanisms are not yet understood. The ODC mRNA has long 5' and 3' untranslated regions (UTRs) which may be involved in the translation

Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development of diabetes in non-obese diabetic (NOD) mice. Here, we hypothesized that oral exposure to a mixture of the endocrine disruptors B

The triglyceride (TG) concentration in plasma is an independent risk factor for coronary heart disease. There is evidence that TG-rich lipoprotein (TGRLP), ie, chylomicrons (CMs), chylomicron remnants (CMRs), and VLDLs associate with factor VII and prothrombin and that the association enhances a platelet factor Xa-mediated prothrombin activation when the CM-prothrombin complex is exposed to platel

EPA (entrustable professional activities) avser aktiviteter som ingår i en läkares dagliga arbete och som läkaren ska klara med en definierad grad av självständighet första dagen som legitimerad läkare.En modell för att träna och bedöma sådana aktiviteter kan säkerställa att studenter klarar av det faktiska arbete som ska utföras första dagen efter legitimation, och den tydliggör också progressionEntrustable Professional Activities (EPAs) define observable key tasks that a doctor should be able to do independently after having completed a certain level of education. Progression is facilitated by frequent assessments of the defined activities, with increased degree of independence. The observations should be supported by constructive feed-forward. EPA is currently used in several countries

This text provides a brief overview of the principles of enzymatic lipid conversion and some recent advances in the enzymatic conversion of glycerophospholipids and galactolipids. Lipases and phospholipases are used to exchange fatty acids or the polar group in the lipids. The reactions can be carried out either as hydrolysis-esterification sequences or as one-step transferase reactions. The scope

Five different β-glycosidases (Pyrococcus furiosus β-glucosidase, Sulfolobus solfataricus β-galactosidase, Caldocellum saccharolyticum β-glucosidase, almond β-glucosidase and Escherichia coli β-galactosidase) were evaluated as transglycosylation catalysts in hexanol containing various amounts of water. All enzymes catalysed both hydrolysis and transglycosylation of the glycosidic substrates (penty

Purpose - Logisticians have always viewed standards as solutions for improving operational compatibility and coordination. This paper aims to contribute to a greater understanding of how standards, upon which logistics systems are designed, developed and coordinated, interact with each other and with other resources in a logistics network for the purpose of improving efficiency and effectiveness.

Construction is claimed to be fragmented, contract focused, short sighted and characterised by price competition. These are typical aspects of what is considered the traditional market approach where each company is seen as autonomous and transaction oriented towards others. During the last few decades, numerous theoretical approaches have questioned these assumptions. Studies also on construction

Drinking water is delivered from the treatment plant to the consumer through kilometres of pipes. Lining these pipes are communities of bacteria living as biofilms. Little is known about the microbial ecology of these biofilms, as access to drinking water pipes for sampling is often limited to pipes sporadically removed for repair or replacement. Bacteria are constantly exchanged between the biofi

(S)-Hydroxynitrile lyases from Hevea brasiliensis, Manihot esculenta, and Sorghum bicolor and (R)-hydroxynitrile lyase from Prunus amygdalus have been used as biocatalyst for the enantiospecific addition of hydrogen cyanide to aldehydes in organic solvents. The effects of the reaction parameters on the enzymatic reaction rate and product enantiomeric excess (e.e.) are presented. The reaction rate

Governments in countries across the world increasingly adopt the “green growth” discourse to underline their ambition for the greening of their economies. The central tenet of this narrative is the economic opportunities rather than challenges arising from the pursuit of environmental sustainability. Our paper synthesises insights from 113 recent scientific articles, dealing with both environmenta

This monograph presents a working description of a special class of acoustical outputs, termed extra-complex sonorities that are the result of desynchronizing robust parameters involved in the production of sound within scaled and multidimensional networks by instruments and voices. The purpose of such a description is to provide a framework for understanding the mechanical and perceptual aspects