Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785 controls from 26 observational studies. All women were post-menopausal

We introduce a new model to address three methodological biases in research on new venture growth and survival. The model offers entrepreneurship scholars numerous benefits. The biases are identified using a systematic review of 96 papers using longitudinal data published over a period of 20 years. They are: (1) distributional properties of new ventures; (2) selection bias; and (3) causal asymmetr

Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i)

Background: Protein truncating variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2 are associated with increased breast cancer risk, but risks associated with missense variants in these genes are uncertain. Methods: We analyzed data on 59,639 breast cancer cases and 53,165 controls from studies participating in the Breast Cancer Association Consortium BRIDGES project. We sampled training (80%) and val

The Secret Diaries of Miss Anne Lister (2010) and Gentleman Jack (2019–2022) are both television dramas based on the private journals of Anne Lister (1791–1840). The diaries were not only partly written in code but make use of idiosyncratic terms, and the two adaptations deal in different ways with the language used in the diaries. This essay examines the language of Anne Lister’s diaries and comp

Background: In Sierra Leone persons with disabilities are at higher risk of living in poverty and have poor access to a fragile healthcare and rehabilitation services. The aim was to explore stakeholders’ perceptions of access to health and rehabilitation services for persons with disabilities in Sierra Leone. Methods: Seven focus group discussions, including stakeholders working within the field

Purpose: The purpose of this study is to conduct a systematic literature review that illuminates the current state of knowledge regarding the specific approaches by which multinational corporations (MNCs) implement corporate social responsibility (CSR) on the subsidiary level in developing countries. Design/methodology/approach: Even though substantial scholarly work has been made to outline MNCs'

The COVID-19 pandemic, climate crisis, and a shifting geopolitical landscape present us with strategic, ethical and planetary dilemmas that demand more reflective action on behalf of actors at every level. The identified challenges of the not-so-distant future require a fundamental transformation of how companies do business, and the role of business schools in shaping the business practices of th

Grocery retail is going through a rapid shift. Consumers now expect to be able to shop online or in stores, get orders delivered when and where they want, and preferably as quickly as possible. This development is called omnichannel and means grocery retailers must transform their logistics networks to meet consumers’ evolving expectations and demands. The omnichannel transformation includes, for Grocery retail is going through a rapid shift. Consumers now expect to be able to shop online or in stores, get orders delivered when and where they want, and preferably as quickly as possible. This development is called omnichannel and means grocery retailers must transform their logistics networks to meet consumers’ evolving expectations and demands. The omnichannel transformation includes, for

Spark ablation is an established method for generating aerosol nanoparticles. By changing the electrodes, synthesis of monometallic, multimetallic and semiconducting nanoparticles has been demonstrated. Apart from using electrodes of specific composition, compositional tuning of bimetallic nanoparticles during synthesis has recently been demonstrated (Kohut, et al., 2021). In many applications, it

We study steady axisymmetric water waves with general vorticity and swirl, subject to the influence of surface tension. This can be formulated as an elliptic free boundary problem in terms of Stokes' stream function. A change of variables allows us to overcome the generic coordinate-induced singularities and to cast the problem in the form “identity plus compact,” which is amenable to Rabinowitz's

Traditionally, LAMs have supported literacy and education primarily by providing and facilitating access to their collections. In tandem with an intensified emphasis on learning, and in particular lifelong learning, in contemporary society, this chapter describes how LAMs have shifted from being enablers of mainly informal and nonformal learning to increasingly becoming places for formal learning

With the development of additive manufacturing, the freedom in developing complex cooling structures has been enlarged greatly. Topology optimization is one of the methods that can give out cooling structures beyond the limits of geometric parameters. In this research, an algorithm of topology optimization with heat transfer is derived. The detailed optimization procedure is presented in this work

The study of nuclei and antinuclei production has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high-energy hadronic collisions. The first measurement of the production of HΛ3 in p-Pb collisions at sNN=5.02 TeV is presented in this Letter. Its production yield measured in the rapidity interval -1

Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark–gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and pp collisions at a nucleon–nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadr