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To know or not to know – parents’ attitudes to and preferences for prenatal diagnosis

Objective: To highlight expectant parents’ attitudes concerning prenatal diagnosis, what the parents wish to know and what they chose not to know about their unborn baby, also in what form and to what extent they wish for prenatal diagnosis. Background: Parents have to make decisions concerning prenatal diagnosis. Screening programmes change rapidly and there is a need for parental influence on th

Film International Issue 9

Contents: Editorial (Michael Tapper), The Corporation: Interview with the Filmmakers (Eija Niskanen), Claire Denis: Cinema of Transgression 1:2 (Robin Wood), Fueled by Enthusiasm: Interview with V.F. Perkins (Jeffrey Crouse), Taiwanese Triads: Mahjong and Goodbye, South, Goodbye (Gina Marchetti). Reviews: books, dvds, films.

Legal certainty in taxation at authorities and courts of law: a nordic view of specialization and unbiasedness

Legal certainty is central to taxation decisions. This article describes the current legal situation and discussions in four Nordic countries. Sweden and Finland are specialized in dealing with taxation cases in administrative courts. In Denmark and Norway, no specialization exists in taxation cases. I maintain in this article that legal certainty would benefit from explicit signals from the state

The BRCA1-Δ11q alternative splice isoform bypasses germline mutations and promotes therapeutic resistance to PARP inhibition and cisplatin

Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impact of mutations on BRCA1 isoform expression and therapeutic response. Cancer cell lines and tumors harboring mutations in exon 11 of BRCA1 express a B

Risk and vulnerability analysis : A feasible process for local climate adaptation in Sweden?

Climate change is an important new challenge for local authorities. This study analyses the potential for using the Swedish mandatory process for risk and vulnerability analysis (RVA) as a vehicle to improve local climate adaptation work. An advantage with RVA is its comprehensive approach in dealing with all relevant threats and all vital functions of society. In order to test the applicability o

Fetal hemoglobin, α1-microglobulin and hemopexin are potential predictive first trimester biomarkers for preeclampsia

Objective Overproduction of cell-free fetal hemoglobin (HbF) in the preeclamptic placenta has been recently implicated as a new etiological factor of preeclampsia. In this study, maternal serum levels of HbF and the endogenous hemoglobin/heme scavenging systems were evaluated as predictive biomarkers for preeclampsia in combination with uterine artery Doppler ultrasound. Study design Case-control

The A(ffective) B(ehavioral) C(ognitive) of Taboo Words in Natural Language: The Relationship Between Taboo Words’ Intensity and Frequency

We investigated the relationship between the affective component (A: the level of offensiveness/intensity) and the behavioral component (B: the frequency of usage) of taboo words that are part of an individual’s natural language (C: the cognitive component). In Study 1, 900 US-residents generated the 10 most common taboo words they use in their daily lives (C). In Study 2, 1000 US-residents were pWe investigated the relationship between the affective component (A: the level of offensiveness/intensity) and the behavioral component (B: the frequency of usage) of taboo words that are part of an individual’s natural language (C: the cognitive component). In Study 1, 900 U.S. residents generated the 10 most common taboo words they use in their daily lives (C). In Study 2, 1,000 U.S. residents w

Sticky income inequality in the Spanish transition (1973-1990)

This paper investigates the evolution of income inequality in Spain during its transition to democracy, suggesting a method for the correction of under-reporting of earnings and profits in the Household Budget Surveys’ data. The contribution is twofold: the methodological proposal, based on income-expenditure discrepancy and scaling-up to National Accounts, improves on previous work, and can be co

Systematic exploration of scenario spaces

Purpose – Scenarios have become a vital methodological approach in business as well as in public policy. When scenarios are used to guide analysis and decision-making, the aim is typically robustness and in this context we argue that two main problems at scenario set level is conservatism, i.e. all scenarios are close to a perceived business-as-usual trajectory and lack of balance in the sense of

Phoxilium® reduces hypophosphataemia and magnesium supplementation during continuous renal replacement therapy

Background Although associated with severe clinical complications, phosphate remains a neglected ion. Additionally, phosphate balance during continuous renal replacement therapy (CRRT) is complex and multifunctional. The present retrospective study investigated the effects of phosphate-containing CRRT fluid on phosphate homeostasis. Methods We retrospectively analysed 112 patients treated with CRR

Objective-oriented product realization: Fundament for a scientific formalism for product realization

The need for a scientific formalism for product realization is the translation of a need onto a product which is developed right in time, at the right costs, and fulfills the specifications set out for the product. To achieve this, most existing methods focus on the customer, or on a key technology as the backbone of product development. In this paper, we claim that efforts must be directed toward

Gender differences in the surgical treatment of lumbar disc herniation in elderly

Purpose: Outcome after lumbar disc herniation (LDH) surgery in middle-aged patient is usually reported to fulfill the criteria for successful outcome. It is also known that women in these years have an inferior outcome compared to men. This study evaluates whether the same gender differences exist in elderly. Method: In the national Swedish register for spine surgery (SweSpine) we identified 1668