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Objective: We aimed to study whether antipsychotic use during pregnancy is associated with gestational diabetes. Methods: This was a Swedish national register‐based cohort study on the Medical Birth Register and the Prescribed Drug Register including all 1,307,487 singleton births between July 2006 and December 2017. Antipsychotics were divided into first-generation antipsychotics (n = 728), high-

In the afterburner assembled with an air-cooled bluff-body flameholder, cooling air is directly injected into the recirculation zone behind the bluff-body, which can reduce the local temperature and increase the oxygen concentration of the gas mixture in the wake of the bluff-body, thereby affecting the total pressure loss and combustion characteristics. To better understand the flow and combustio

Camelina sativa (Camelina) is an oilseed crop that in recent years has gained importance due to its closeness to the plant model organism Arabidopsis thaliana (Arabidopsis), its low agronomical requirements, and the ability to grow under temperate conditions. To explore all the agronomical and biotechnological possibilities of this crop, it is important to evaluate the usability of the molecular p

The Education Act from 2010 states that education in Sweden ought to be based on scientific knowledge and proven experience. The aim of this study is to explore practice-near school research published by Swedish researchers in the wake of the Education Act with the focus on the participation of teachers in research. As a background, the international and national roots of practice-near school rese

The human host defense peptide LL-37 has an essential role in the first line of defense against invading pathogens. This cathelicidin is mainly produced by immune cells and epithelial cells aligning the mucosal areas and is normally upregulated upon infection and inflammation. LL-37 displays direct antimicrobial activity against a variety of pathogens, but also modulates the immune responses by ac

Rare disease data is often fragmented within multiple heterogeneous siloed regional disease registries, each containing a small number of cases. These data are particularly sensitive, as low subject counts make the identification of patients more likely, meaning registries are not inclined to share subject level data outside their registries. At the same time access to multiple rare disease datase

Background: Preservatives are usually added to a wide array of consumer products to prevent growth of microbes and to prevent product destabilization and degradation. However, many of these preservatives are common skin sensitizers and may cause allergic contact dermatitis. The amount of preservatives may vary per country or region according to their respective legislation and may be reported in d

This paper develops a conceptual framework for understanding how organizations create an accepted purpose for organizational change initiatives related to business processes. The framework is based on a longitudinal study related to an Action Research project and the ‘higher level learning’ from using a performance measurement system for change initiatives. Over more than four years, we followed a

Introduction: Glucose absorption during peritoneal dialysis (PD) is commonly assumed to occur via paracellular pathways. We recently showed that SGLT2 inhibition did not reduce glucose absorption in experimental PD, but the potential role of glucose transport into cells is still unclear. Here we sought to elucidate the effects of phlorizin, a non-selective competitive inhibitor of sodium glucose c

Objective: Antimicrobial resistance is a growing worldwide problem and is considered to be one of the biggest threats to global health by the World Health Organization. Insights into the determinants of antibiotic prescribing may be gained by comparing the antibiotic usage patterns of Australia and Sweden. Design: Publicly available data on dispensed use of antibiotics in Australia and Sweden betw

Background: Unresectable disease is sometimes diagnosed during surgery in patients with pancreatic ductal adenocarcinoma (PDAC). This study aimed to identify preoperative risk factors for metastatic disease diagnosed at surgical exploration and to investigate and compare survival in resected and non-resected patients. Methods: Patients were identified from the Swedish National Pancreatic and Peria

Background: Evidence concerning the reduction of postoperative complications due to smoking and alcohol drinking in patients undergoing radical cystectomy is incomplete. Objective: To evaluate the efficacy of a 6-wk smoking and/or alcohol cessation intervention, initiated shortly before surgery and continued until 4 wk after, in reducing complications. Design, setting, and participants: Between 20

Simultaneous Digital Breast Tomosynthesis (DBT) and mechanical imaging (MI), called DBTMI, is a novel breast imaging method aimed at improving sensitivity and specificity of breast cancer screening. DBTMI combines improved cancer detection by three-dimensional DBT imaging, with the analysis of local stress over the compressed breast by MI, which can reduce false positive findings. The MI signal is

Aim: To describe eating and drinking ability in adults with cerebral palsy (CP) relative to sex, age, subtype, and severity of gross motor and hand function and nutritional status. Method: This was a cross-sectional study based on data of 2035 adults with CP, median age 26 years (range 18–78 years). The Eating and Drinking Ability Classification System (EDACS), Gross Motor Function Classification

We conducted a phase I-IIa, randomized, monocentric, double-blind, placebo-controlled clinical trial to evaluate the safety and impact of the combination treatment of Itolizumab and insulin on preserving beta cell function in adults with recent-onset type 1 diabetes. Twelve patients were randomly assigned to three treatment groups, each receiving a different Itolizumab dose (0.4/0.8/1.6 mg/kg body

Postural instability in Parkinson’s disease (PD) is associated with several downstream consequences that ultimately lead to a greater risk of falling. Among the prominent downstream consequences is fear of falling (FOF), which is both common and problematic in PD. It can lead to a vicious cycle of FOF avoidance behavior that results in more sedentary behavior, physical deconditioning, and weakenin