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Immunotherapy has shown limited success in acute myeloid leukemia (AML), indicating an incomplete understanding of the underlying immunoregulatory mechanisms. Here we identify an immune evasion mechanism present in 60% of AML cases, wherein primitive AML cells aberrantly express the lymphoid surface protein SLAMF6 (signaling lymphocyte activation molecule family member 6). Knockout of SLAMF6 in AM

PurposeThe purpose of this study is to empirically explore how contractual learning in public procurement is affected by organizational design.Design/methodology/approachTwo inductive case studies are based on semi-structured interviews and document analysis.FindingsThe author finds that the consolidation of economic, technical and legal tasks in specific units can strengthen contractual learning

Background: Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with lower bone mineral content (BMC) and density (BMD) in children, but prospective studies remain limited. We aimed to investigate associations between prenatal and childhood PFAS exposure and BMC/BMD at age 9 years, following up on our previous findings from age 7 years. Methods: We used data from the Odense

The importance of older adults’ participation in policymaking is increasingly recognized, but the nuanced participation processes remain insufficiently understood. This scoping review aims to map existing research on older adults’ participation in policymaking, focusing on who participates, their activities and contributions, resulting outputs and outcomes, and the enablers and barriers affecting

Interest in Jane Austen’s fiction and life has never been greater than today. Her narrative works and worlds live on 200 years after their publication not only through their own popularity, but also through numerous re-presentations in the forms of novels, movies, television series, and fan fictions that keep flourishing from her fictional worlds and characters. Austen’s novels, her settings, and

Denna avhandling utvecklar och utvärderar språkbaserade bedömningar som använder artificiell intelligens (AI) för att omvandla öppet språk till kvantitativa indikatorer och beskrivningar av psykiska hälsorelaterade konstruktioner. Medan slutna skalor länge har dominerat psykologiska bedömningar, är de begränsade av fasta svarsformat och kanske inte helt fångar komplexiteten i individers upplevelseThis thesis develops and evaluates language-based assessments that use artificial intelligence (AI) to transform open-ended language into quantitative indicators and descriptions of mental health related constructs. While closed-ended scales have long dominated psychological assessment, they are limited by fixed response formats and may not fully capture the complexity of individuals’ experiences.

BackgroundIbrutinib, a Bruton tyrosine kinase inhibitor, prolongs progression-free survival when added to immunochemotherapy as first line treatment. The ENRICH trial compared the chemotherapy-free combination of ibrutinib and the anti-CD20 antibody rituximab (ibrutinib–rituximab) with standard immunochemotherapy (R-CHOP [rituximab–cyclophosphamide, doxorubicin, vincristine, and prednisolone] or b

AI-enhanced search applications are evolving rapidly, promising to answer complex queries with simple answers, but this creates new challenges on how users evaluate the information presented to them. This study investigates how four AI-enhanced search applications (ChatGPT, Gemini, Copilot and You.com) respond to questions about erectile dysfunction drugs in Sweden, which risks creating digital gr

Digital Transformations of Illicit Drug Markets: Reconfiguration and Continuity is authored by leading experts in the field of illicit drug sourcing, who draw on their interdisciplinary backgrounds to illustrate how modern technologies are embedded within our social structures. Since the digital (r)evolution, the sourcing of illicit drugs now takes place through smartphones, encryption, social med

This thesis investigates the role of politeness in human-robot interaction and its effect on comfortability, social perception and collaboration. The study utilizes the humanoid robot Epi, which provides step-by-step instructions for two Lego-building tasks. Politeness was manipulated in the tasks so that the participants one time interacted with Epi while Epi used polite communication towards the

This study examines whether unstructured and structured activities interact in their association with delinquency and cannabis use. We hypothesize that unstructured activities are more strongly associated with delinquency and cannabis use for those who are less engaged in structured activities. Data are drawn from three nationally representative self-report studies conducted between 2005 and 2011