Mantle cell lymphoma (MCL) is a distinct subtype of malignant lymphoma which is characterized by the chromosomal translocation t(11;14)(q13;q32) resulting in constitutional overexpression of cyclin D1 and cell cycle dysregulation in almost all cases. Clinically, MCL shows an aggressive clinical course with a continuous relapse pattern and a median survival of only 3-5 years. However, recently a su

Disease related mutations and environmental factors are key determinants of the aggregation mechanism of the amyloid-β peptide implicated in Alzheimer's disease. Here we present an approach to investigate these factors through acquisition of highly reproducible data and global kinetic analysis to determine the mechanistic influence of intrinsic and extrinsic factors on the Aβ aggregation network.

A key component in low energy houses is the heat recovery from the ventilation air. Over recent years, the most frequently used ventilation type is the mechanical ventilation with heat recovery. This kind of ventilation results in high heat recovery but does unfortunately consume a considerable amount of electrical energy. Natural or hybrid ventilation has the potential to consume less electricity

We study the association of the cationic protein lysozyme with several almost neutral protein fragments but with highly uneven charge distributions. Using mesoscopic protein models, we show how electrostatic interactions can align or steer protein complexes into specific constellations dictated by the specific charge distributions of the interacting biomolecules. Including van der Waals forces sig

OBJECTIVE: To examine the mortality risk of blood transfusions when donor information, postdonation treatment, and a wide selection of risk factors are taken into account. METHODS: A retrospective study was performed on 9907 patients who underwent coronary artery bypass grafting and/or aortic valve replacement. Several transfusion-related risk factors, including age of blood products, sex of don

Popular Abstract in Swedish Högt blodtryck (hypertoni) är en folksjukdom. Omkring 1,8 miljoner personer i Sverige, motsvarande 25 % av den vuxna befolkningen över 20 år, lider av hypertoni. I 90 % av fallen är orsaken okänd och klassificeras då som essentiell/primär hypertoni. Vid sekundär hypertoni finns det en eller flera bakomliggande orsaker till det höga blodtrycket, till exempel: förträngninArterial hypertension is a very common disorder. In most cases the cause is unknown and therefore classified as essential or primary hypertension. Primary aldosteronism (PA), characterized by an inappropriate aldosterone secretion, has traditionally been estimated to account for approximately 1 % of all hypertensive cases. By using the aldosterone to renin ratio (ARR) as a screening tool, the dete

We present a Monte Carlo study of dijet angular distributions at root s = 14 TeV. First we perform a next-to- leading order QCD study; we calculate the distributions in four different bins of dijet invariant mass using different Monte Carlo programs and different jet algorithms, and we also investigate the systematic uncertainties coming from the choice of the parton distribution functions and the

Computerized continuous monitoring of soil respiration rates before and during glutamic acid decomposition in heavy metal polluted soils was used to determine four microbial parameters: basal respiration rate, substrate induced respiration rate, lag time before the exponential increase of the soil respiration rate and the specific respiration increment during the exponential phase. Both smelter- a

Despite its importance in evolutionary biology, studies of the pattern of disease resistance in natural populations are rare. In this paper, we report patterns of infection of a viral eye disease in juvenile Swedish common lizards (Lacerta vivipara). Females were sampled at random from natural populations immediately prior to parturition with equal exposure of pathogens for all lizards once in cap

Fe2+ in pyrite is found in a low-spin d(6) configuration, a necessary condition for diamagnetic and semi-conducting properties of material. The semi-conducting property of pyrite has been studied since the time when pyrite was used as a rectifier in early radios. Pyrite posses the highest possible crystal field stabilisation energy and offers a better altemative as solar material compared to Si- b

The value of the two-particle density function at coalescence is frequently used as an additional variable for formulating approximate exchange-correlation or correlation functionals. Here, its applications as one of the key variables for the construction of new DFT (preferably multi-determinant) functionals is investigated. The basic formalism is presented and it is shown that this replacement av

Background: in traditional medicine, blueberries have been used to facilitate blood glucose regulation in type 2 diabetes. Recent studies in diabetic mice have indicated facilitated glycaemic regulation following dietary supplementation with extracts from European blueberries, also called bilberries, (Vaccinium myrtillus). The purpose of the present study was to investigate the impact of fermented

ObjectiveTo assess the role of the placental arterial Doppler examination at 23-24 gestational weeks for predicting adverse perinatal outcome in high-risk pregnancies. DesignRetrospective register study. SettingSkane University Hospital in Malmo. PopulationSix hundred and forty-five women with high-risk pregnancies, without fetal malformations or chromosomal abnormalities. MethodsPlacental (uterin