Huntington disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, but underlying mechanisms are not fully known. As the IKKβ/NF-κB pathway is an essential regulator of metabolism, we investigated the involvement of IKKβ, the upstream activator of NF-κB in hypothalamus-specific HD metabolic ch

Data-independent acquisition-mass spectrometry (DIA-MS) is the method of choice for deep, consistent, and accurate single-shot profiling in bottom-up proteomics. While classic workflows for targeted quantification from DIA-MS data require auxiliary data-dependent acquisition (DDA) MS analysis of subject samples to derive prior-knowledge spectral libraries, library-free approaches based on in silic

Electric buses can improve the environmental performance of public transport. Yet, introducing electric buses brings novel challenges, such as requirements for operational changes, new forms of institutional collaboration, increased investment costs and technological concerns. This paper investigates these challenges and strategies for managing them by comparing experiences of electric bus impleme

BACKGROUND: A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between n

This paper summarizes my dissertation. I have analyzed the emergence, establishment and expansion of fear of crime research in Sweden, shared some key results and discussed theoretical implications of these results.

Humans have an inquiring mind. Throughout history, one may find documentation that shows on human curiosity, and our drive to stretch boundaries to satisfy it. Thus, this is not something that characterizes our time in any particular way. Sources, for instance, from the 13th century can serve as good examples that support such an assumption. Mary Shelley’s novel from the 19th century, “Frankenstei

Hermeneutik, vetenskapen om tolkning, förknippar vi kanske vanligen med textstudier, men begreppet har kommit att få en vidare betydelse inom fenomenologin genom filosoferna Heidegger och Gadamer på ett sätt som är relevant för det psykoterapeutiska arbetet. Syftet med denna essä är att fördjupa diskussionen om dialektiken mellan det tolkande jaget och den andre, och spegla den mot en psykoterapeu

The Plot Against America is a 2020 American tv-series, created by David Simon and Ed Burns. It consists of six, one-hour long episodes and was produced by Home Box Office. The series is an adaptation of Philip Roth’s 2004 novel. It is built on a counterfactual and para-fictional historical narrative, depicting the years 1940-42. Here, the hero pilot Charles Lindbergh becomes American president in

Calculating the electronic structure of systems involving very different length scales presents a challenge. Empirical atomistic descriptions such as pseudopotentials or tight-binding models allow one to calculate the effects of atomic placements, but the computational burden increases rapidly with the size of the system, limiting the ability to treat weakly bound extended electronic states. Here

Climate change substantially affects plant phenology, resulting in earlier vegetation onset across temperate and boreal regions. Phenological shifts caused by warming may alter species interactions across trophic levels because of species-specific responses, and influence the reproductive success of dioecious species if the phenological sensitivity to warming (ST) differs between genders. We used

Tools for accurate measurements of microbial biomass/abundance are imperative in soil ecology. This perspective was prompted by a lack of consistency in how the neutral lipid fatty acid (NLFA) and phospholipid fatty acid (PLFA) 16:1ω5 are used to estimate arbuscular mycorrhizal (AM) fungal abundance, which we argue can lead to erroneous conclusions within studies and complicate among-study compari

Continuous and biostratigraphically well-constrained carbon isotope (δ13Corg) profiles through the upper Miaolingian (middle Cambrian) to Tremadocian (Lower Ordovician) part of the Alum Shale Formation in four drill cores from southernmost Scandinavia are described. The sections record seven Furongian (upper Cambrian) excursions/spikes, of which three appear valuable as auxiliary markers for ident

The human population is still facing appalling conditions due to several outbreaks of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus. The absence of specific drugs, appropriate vaccines for mutants, and knowledge of potential therapeutic agents makes this situation more difficult. Several 1, 2, 4-triazolo [1, 5-a] pyrimidine (TP)-derivative compounds were comprehensively studie

Explosive volcanic eruptions can reach the stratosphere and cause elevated concentrations of sulphate particles for months to years. When these particles descend into the troposphere, they can impact cirrus clouds though to what degree is unknown. In this study, we combine three satellite data sets to investigate the impact of downwelling sulphate aerosol on midlatitude cirrus clouds during spring