In women experiencing distressing climacteric symptoms during the peri- and postmenopause there is conclusive evidence from abundant randomised controlled trials that systemic hormone replacement therapy (HRT) of any type affords symptom relief, with no alternative treatment producing similar effect. Though this evidence is accumulating, the question of how to provide best clinical practice in an

In this article a method to estimate the mean upcrossing intensity, mu(u), of a stochastic process is proposed. It is assumed that the stochastic process is a sum of a Gaussian process and a second-order correction term. The method is based on the two-dimensional Saddlepoint approximation. The accuracy of the method is tested on processes having analytical solutions for mu(u). Numerical examples a

Nuclear chirality is a novel manifestation of spontaneous symmetry breaking resulting from an orthogonal coupling of angular momentum vectors. In triaxial nuclei with an odd number of protons and neutrons three perpendicular angular momenta provided by the valence particles and collective rotation can form two systems of opposite handedness. The electromagnetic properties of the resulting doublet

When radio-iodine was first used in the treatment of metastasized thyroid carcinoma in 1943, its success in terms of tumour response, quality of life improvement and survival was considered a 'miracle', as in those days metastatic cancer was generally fatal. Inspired by this, many efforts have been made to apply radioisotope therapy to other tumours. Radionuclide therapy uses radioactive isotopes

The three populations of squid cranial cartilage proteoglycans, D1D1A, D1D1B and D1D2 appeared to have a high degree of polydispersity. Gel electrophoresis and immunoblotting analysis showed that polydispersity was mainly due to the variable size of chondroitin sulphate E chains. This was further ascertained after rotary shadowing electron microscopy of proteoglycan core proteins and glycosaminogl

Stomach content analysis showed that Kyphosus sydneyanus collected by spearing from coastal reefs near Leigh, north-east New Zealand, is herbivorous throughout its post-settlement life. All size classes collected consumed a wide range of macroalgae, predominantly the phaeophytes Carpophyllum maschalocarpum and Ecklonia radiata, and the rhodophytes Gigartina macrocarpa and Caulacanthus ustulatus. M

Objective We studied fertility and history of child sexual abuse (CSA) in a representative group of anorexia nervosa (AN) cases. Method Fifty-one adolescent-onset AN cases recruited after community screening and 51 matched comparison cases were interviewed 10 years after reported AN onset, at mean age 24 years, regarding children, miscarriages, and fertility problems. They completed anonymousl

We show that operator-valued Bergman inner functions have the so-called expansive multiplier property generalizing a well-known result of Hedenmalm in the scalar case. This analysis leads to norm bounds for input output maps for a related class of discrete time linear systems. The proof uses properties of the biharmonic Green function. (C) 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Background The long-term outcome of anorexia nervosa is insufficiently researched. Aims To study prospectively the long-term outcome and prognostic factors in a representative sample of people with teenage-onset anorexia nervosa. Method Fifty-one people with anorexia nervosa, recruited by community screening and with a mean age at onset of 14 years were compared with 51 matched comparison individu

Recently, we showed that 10.2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch test-positive fragrance allergen in patients previously diagnosed with hand eczema to explore whether immersion of fingers in a solution with or without the

This study investigated the effect of two types of feedback (confirmatory and disconfirmatory) on the accuracy in witnesses' confidence judgements of their event memory. Overall, the witnesses evidenced overconfidence both when they received feedback and in the Control condition (no feedback). The results showed that confirmatory feedback caused higher overconfidence, compared both with when recei

The aim of this study was to investigate from the perspective of formal carers the care given to people aged 65 and over, who are cared for in their own homes by informal care. Thirty-three district nurses (DNs) and 20 home service assistants in a municipality with 13500 inhabitants (over 65 years old), were interviewed about the location of care recipients and 398 care recipients were located. Mo

Pilosella floribunda (Wimm. and Grab.) Arv-Touv. is reported as new to the provinces Skane and Smaland, southernmost Sweden. There is one recent finding in each of these provinces, in both cases as an established alien on roadsides. Hieracium nemorivagum Jord. ex Boreau, has recently been found at several sites in eastern Skane and at one site in each of the provinces Blekinge and Smaland. This sp

Eighty-six patients with monosymptomatic optic neuritis of unknown cause were followed prospectively for a median period of 12.9 years. At onset, cerebrospinal fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) was establi

Time-series of NASA/NOAA Pathfinder AVHRR Land (PAL) data have been analysed to extract parameters describing the seasonality of vegetation in Africa. Two methods have been developed to fit smooth curves to the time-series. The first method is based on an adaptive Savitzky-Golay filtering technique, and the second on non-linear least-squares fits of asymmetric Gaussian model functions. Both proces

Protein phosphorylation and subsequent dephosphorylation was studied in digitonin-permeabilized neuroblastoma SH-SY5Y cells by measuring the incorporation of [32P]phosphate into myelin basic protein (MBP). 1,2-Dioctanoyl-sn-glycerol (DOG) and calcium synergistically induced phosphorylation of MBP, which was inhibited by the protein kinase C (PKC) pseudosubstrate peptide (PKC19-36). The phosphoryla

Objective: To use proteomic analysis of cerebrospinal fluid to discover novel proteins and peptides able to differentiate between patients with stable mild cognitive impairment (MCI) and those who will progress to Alzheimer disease (AD). Design: Baseline cerebrospinal fluid samples from patients with MCI and healthy controls were profiled using surface-enhanced laser desorption/ionization time-off

Candida albicans is the most prevalent yeast pathogen in humans, and recently it has become increasingly resistant to the current antifungal agents. In this study we investigated C. albicans dihydroorotate dehydrogenase (DHODH, EC 1.3.99.11), which catalyzes the fourth step of de novo pyrimidine synthesis, as a new target for controlling infection. We propose that the enzyme is a member of the DHO