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The search for drugs that modulate NMDA receptors has been very active in the latest decades since they play a pivotal role in neuronal death and in several neurological conditions, including stroke, traumatic brain injury, and neurodegenerative diseases. Activating the receptor evokes an entry of calcium into the neuron, thus leading to a rapid depolarization that can be measured using electrophy
As global climate change intensifies, the question of what makes a place habitable or uninhabitable is critical, particularly in the context of a potential future climate outside the realm of lived experience, and the possible concurrent redistribution of populations partly associated with such climatic shifts. The concept of habitability holds the potential for advancing the understanding of the
The life of cutting tool inserts is critically important for efficient machining, reducing manufacturing cost, embedded energy, and enabling more complex parts to be machined. For these applications, cemented carbide (WC-Co) materials are a prime candidate. The performance of these materials can be limited by early fracture, typically via an intergranular fracture path with respect to carbide grai
We study the problem of computing the Voronoi diagram of a set of.n2 points with.O(log n)-bit coordinates in the Euclidean plane in a substantiallysublinear in . n number of rounds in the congested clique model with . n nodes.Recently, Jansson et al. have shown that if the points are uniformly at random distributed in a unit square then their Voronoi diagram within the square can be computed in.O(
Early studies on water - n-alkane - ionic surfactant microemulsions provide first hints for the possible existence of a foam-like nanostructure, i.e. a dense packing of polyhedral nanometer-sized water droplets separated by a thin layer of a continuous oil phase. Indeed, we found a foam-like structure in the system water/NaCl - hexyl methacrylate (C6MA) - dioctyl sulfosuccinate sodium salt (AOT).
Background: Dyslipidaemia in patients with diabetes contributes to the risk of atherosclerotic cardiovascular disease. We aimed to identify a dyslipidemic profile associated with both dysglycemia and subclinical coronary atherosclerosis. Methods: Study participants (n = 5050) were classified in three groups: normoglycemia, pre-diabetes, and diabetes. A coronary artery calcium score (CACS) > 0 defi
For effective mixing within microfluidic devices through the application of obstacle-based structures, a straightforward approach involves in-situ fabrication, such as the free-radical photopolymerization of hydrogel structures. However, oxygen inhibition presents a challenge for polydimethylsiloxane (PDMS)-based microfluidic chips. In this paper, we present a solution to the problem of hydrogel-s
Introduction: No national recommendation for antibiotic prophylaxis for planned caesarean section in Sweden exists. Swedish delivery units have chosen different strategies. Some units routinely administer antibiotic prophylaxis to all women for whom a caesarean section is planned, while other units give prophylactic antibiotics to risk groups only. We took advantage of this “natural experiment” to
Semiconductor nanowires (NW) have been of interest to optoelectronics research for several decades due to the unique optical effects resulting from their geometry. Today, NWs are fabricated from a wide range of materials, ranging from Si to III-Vs and emerging materials like metal-halide perovskites (MHPs). Among NW devices, single NW devices are of special interest because they offer both a usefu
BACKGROUND AND PURPOSE: Adaptive radiotherapy (ART) involves treatment re-planning based on anatomical changes, which may improve target coverage and sparing of organs-at-risk (OARs). This study retrospectively assessed the technical feasibility and potential benefits of daily ART in combination with reduced planning target volume (PTV) margins for head and neck squamous cell carcinoma (HNSCC).MAT
BACKGROUND: Lung transplantation remains hampered by a scarcity of viable donor lungs, partially attributed to donor lung injuries.METHODS: Three porcine lung injury models were studied: infection-induced using lipopolysaccharide (n = 7), aspiration-induced using endotracheal gastric content (n = 7), and injury using lavage and harmful ventilation (ventilator-induced lung injury; n = 7). Molecular
Purpose: Obstructive sleep apnea (OSA) is a common disease in patients with coronary artery disease (CAD). Approximately 40–80% of cardiovascular disease patients have obstructive sleep apnea. The manifestation of it can vary significantly in different types of CAD patients. This systematic review and meta-analysis investigate the prevalence and severity of OSA in patients with acute coronary synd
Introduction: The adoption of non-inferiority trial designs for assessing new interventions in stroke treatment is on the rise. We designed a survey to assess stroke specialists' understanding and familiarity with non-inferiority trials and margins. Methods: A brief web-based questionnaire was sent to the members of the World Stroke Organization (WSO). The median acceptable non-inferiority margins
Home heating transitions influence sociocultural practices and bring about structural changes in daily life. To uncover the power dynamics underpinning these transformations, this paper applies a visionary framework for feminist energy systems designed to challenge hegemonic and unsustainable energy cultures in pursuit of a more just and equitable future. Drawing on the framework's political, econ
Hypothesis: Phospholipids are widely used in food and pharmacological formulations. However, these typically suffer from limitations such as low colloidal stability. Promising stability has been observed for vesicles based on phosphatidylglucose (P-Glu), but fundamental knowledge on this lipid is missing and those observations were made using P-Glu containing mixed acyl groups. The acyl groups are
Computational dosimetry using Monte Carlo radiation transport simulations was applied for the 2019 European Radiation Dosimetry Group (EURADOS) and Running the European Network of Biological and retrospective Physical dosimetry (RENEB) field test, an exercise of retrospective dosimetry techniques for a realistic small-scale radiological accident. The simulations were performed at four institutes,
This chapter looks at the DMA through the prism of pre-emption and the relationship between EU and national law. It explains the fundamentals of pre-emption in EU law and shows the consequences for the DMA and national rules that are to ensure fairness in the digital market space. It argues that fairness in the digital market with regard to business users and consumers has been exhaustively regula
This study analyses how the standard of living for different social groups changed when Sweden developed from an agricultural to an industrial society and when the first steps towards a modern welfare society were taken. As a measure of living standards, we use the ability to overcome short-term economic stress caused by high food prices. We use individual-level longitudinal data from 1813 to 1967
Many studies have underscored the impacts of drought on ecosystems, and some researchers reported the effects of accumulated soil moisture deficit (ASMD) on light use efficiency (LUE) in grassland. However, the potential effects of ASMD on gross primary productivity (GPP) and LUE for both cropland and forest ecosystems are still not understood. This study elucidated the effects of accumulated and
