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We study the permeability and selectivity ('permselectivity') of model membranes made of polydisperse polymer networks for molecular penetrant transport, using coarse-grained, implicit-solvent computer simulations. In our work, permeability P is determined on the linear-response level using the solution-diffusion model, P = KDin, i.e., by calculating the equilibrium penetrant partition ratio K and
BACKGROUND: Engagement in activities meaningful to the individual may support the process of recovery in those with mental illness. Persons with psychiatric disabilities may reduce their engagement in meaningful activities to various degrees with possible fluctuations over time. We hypothesized that activity engagement can be altered when opportunities and support are offered at an individual and
This special issue collects selected and reviewed full papers presented at 22nd European Conference of Fracture (ECF22) titled ‘Loading and environment effects on structural integrity’, held in Belgrade, Serbia, August 26–31, 2018.
The stability of biologically produced pharmaceuticals is the limiting factor to various applications, which can be improved by formulation in solid-state forms, mostly via lyophilization. Knowledge about the protein structure at the molecular level in the solid state and its transition upon rehydration is however scarce, and yet it most likely affects the physical and chemical stability of the bi
Phototropins are photoreceptor proteins that regulate blue light-dependent biological processes for efficient photosynthesis in plants and algae. The proteins consist of a photosensory domain that responds to the ambient light and an output module that triggers cellular responses. The photosensory domain of phototropin from Chlamydomonas reinhardtii contains two conserved LOV (light-oxygen-voltage
Background: α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson's disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human familial PD substitution A53T, yet in contrast to A53T patients, mice show no evidence of aSyn neuropathology even after aging. Here, we studied the neur
The degradation potential of micropollutants and transformation products in biological post-treatment after ozonation is partly unknown. A pilot plant with ozonation and subsequent biological treatment in a moving bed biofilm reactor (MBBR) was thus operated over 16 months to investigate the removal of micropollutants and the formation and removal of N-oxide transformation products. Lab-scale kine
The central challenge tackled in this thesis is the development of an optical imaging approach capable of multidimensional image capture of dynamic samples. Many conventional optical imaging approaches, which can obtain dimensional information such as spectral, polarisation, or volumetric, to name a few, about samples either employ sequential image capture or parallelised detector arrangements. Du
Since tillage can reduce the amount of organic C stored in soils, the use of conservation tillage practices, which exclude soil inversion, or include it less frequently, is often promoted. Soil microorganisms are closely linked to soil organic C (SOC), and they are assumed to respond quicker to management changes than SOC. Using two Swedish long-term tillage experiments, our aim was to determine w
Despite a few reports of photoluminescent and strongly photo-oxidizing transition metal complexes with a d5 electronic configuration, the photophysics and photochemistry of this class of transition metal complexes have largely remained unexplored. Recent investigations of earth-abundant iron(III) N-heterocyclic carbene (NHC) complexes have demonstrated promising photophysical and photochemical pro
Almost any conversation about Historical International Relations (IR) appears to be, at least implicitly, always already about Europe. The geographical and intellectual centrality of Europe shapes the way in which historically oriented work in IR operates. Paradoxically, despite a long and powerful lineage of disciplinary Eurocentrism, Europe has only rarely emerged as a conceptual focal point of
Digital twins, which are a new concept in industrial control systems (ICS), play a key role in realizing the vision of a smart factory, and they can have different effective use cases. With digital twins, we have virtual replicas of physical systems so that they precisely mirror the internal behavior of the physical systems. Hence, synchronization is necessary to keep the states of digital twins i
Digitaliseringen gör det möjligt för näringsidkare att utveckla nya affärsmodeller, upptäcka nya marknader och att rationalisera sina verksamheter.En viktig aspekt i denna utveckling utgör att samla in, behandla och på olika sätt utnyttja personuppgifter av såväl befintliga som presumtiva kunder. Av den anledningen existerar ett naturligt samband mellan personuppgifter och näringsverksamhet och fr
EU:s dataskyddsförordning innehåller bestämmelser om vissa ideella organisationers behörighet att uppträda som ombud för registrerade samt om sådan organisationers talerätt. Syftet med denna artikel är att undersöka vilka möjligheter sådana organisationer enligt gällande svensk rätt har att delta i övervakningen av dataskyddsreglernas efterlevnad.
Background: Distal cholangiocarcinoma is an aggressive malignancy with a dismal prognosis. Diagnostic and prognostic biomarkers for distal cholangiocarcinoma are lacking. The aim of the present study was to identify differentially expressed proteins between distal cholangiocarcinoma and normal bile duct samples. Methods: A workflow utilizing discovery mass spectrometry and verification by parallel
Deoxyribonucleoside triphosphates (dNTPs) are vital for the biosynthesis and repair of DNA. Their cellular concentration peaks during the S phase of the cell cycle. In non-proliferating cells, dNTP concentrations are low, making their reliable quantification from tissue samples of heterogeneous cellular composition challenging. Partly because of this, the current knowledge related to the regulatio
BACKGROUND: Rehabilitation pathways are crucial to reduce stroke-related disability. Motivational Interviewing (MI), as a person-centered complex intervention, aimed to empower and motivate, and could be a resource to improve rehabilitation outcomes for older stroke survivors. The IMAGINE project aims to assess the impact of MI, as a complement to standard geriatric rehabilitation, on functional i
