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Fluorescence studies on the interaction between pyrene-labelled poly(acrylic acid) and cyclodextrins

The interactions, in aqueous media, between a pyrene-labelled polyelectrolyte poly(acrylic acid) (PAAMePy) with two different degrees of labelling and beta- and gamma-cyclodextrins (beta- and gamma-CD) were studied using absorption and fluorescence (steady-state and time-resolved) techniques. In addition to qualitative and quantitative parameters obtained from absorption and steady-state fluoresce

Are incubation costs in female pied flycatchers expressed in humoral immune responsiveness or breeding success?

Although clutch size variation has been a key target for studies of avian life history theory, most empirical work has only focused on the ability of parents to raise their altricial young. In this study, we test the hypothesis that costs incurred during incubation may be an additional factor constraining clutch size in altricial birds. In the pied flycatcher (Ficedula hypoleuca), we manipulated t

Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension

The enzyme 11 beta-hydroxysteroid dehydrogenase type 2 (11BHSD2) converts cortisol to cortisone in the kidney, thereby protecting the mineralocorticoid receptor from the mineralocorticoid actions of cortisol. The syndrome of Apparent Mineralocorticoid Excess (AME), a rare monogenic form of early onset hypertension with autosomal recessive inheritance, is caused by homozygous or compound heterozygo

Nucleation and crystal growth in supersaturated solutions of a model drug

The crystallization Process in aqueous solutions of the drug bicalutamide and the effect of the polymer polyvinylpyrrolidone (PVP) have been studied. Results showed that PVP decreased the crystallization Fate significantly in a system with PVP concentrations as low as 0.01% (w/w), without changing the polymorph formed. The crystal habit was altered already at PVP concentrations as low as 0.001% (w

Adopting a component-based software architecture for an industrial control system - A case study

This chapter presents a case study from a global company developing a new generation of programmable controllers to replace several existing products. The system needs to incorporate support for a large number of I/O systems, network types, and communication protocols. To leverage its global development resources and the competency of different development centers, the company decided to adopt a c

Smoking and Risk for Amyotrophic Lateral Sclerosis: Analysis of the EPIC Cohort

Objective: Cigarette smoking has been reported as "probable" risk factor for Amyotrophic Lateral Sclerosis (ALS), a poorly understood disease in terms of aetiology. The extensive longitudinal data of the European Prospective Investigation into Cancer and Nutrition (EPIC) were used to evaluate age-specific mortality rates from ALS and the role of cigarette smoking on the risk of dying from ALS. Met

Higher Early Mortality with Simultaneous Rather than Staged Bilateral TKAs Results From the Swedish Knee Arthroplasty Register

Patients with knee osteoarthritis (OA) often present with symptoms that warrant bilateral TKAs. There are potential benefits to operating on both knees on the same day, but the safety of simultaneous bilateral TKAs has been questioned. To evaluate whether there were any differences in 30-day mortality between patients having simultaneous bilateral TKAs and those having staged bilateral TKAs, we an

Structure of microemulsion - ABA triblock copolymer networks

Structural equilibrium properties of transient networks formed by microemulsion droplets and ABA triblock copolymers in solution have been studied by Monte Carlo simulation. The droplets were represented by soft spheres, and the polymers were represented by junctions connected by harmonic bonds with an angular potential regulating the intrinsic chain stiffness. The interaction parameters were sele

Sex pheromone mimicry in the early spider orchid (Ophrys sphegodes): patterns of hydrocarbons as the key mechanism for pollination by sexual deception

Abstract We investigated the female-produced sex pheromone of the solitary bee Andrena nigroaenea and compared it with floral scent of the sexually deceptive orchid Ophrys sphegodes which is pollinated by Andrena nigroaenea males. We identified physiologically and behaviorally active compounds by gas chromatography with electroantennographic detection, gas chromatography-mass spectrometry, and beh

Asymmetric contests over resources for survival and migration: a field experiment with bluethroats

The relative importance of prior occupancy and of asymmetries in both value of winning and in resource-holding potential for the outcome of animal contests was tested. Bluethroats, Luscinia s. svecica, were offered food ad libitum in the field. Prior to migration, at a moulting site, their weight increased rapidly and peaked after a few days. Lean birds won significantly more interactions than fat

Violet diode laser in time-resolved stored-ion spectroscopy

Lifetime measurements of the metastable 3d D-2(3/2) level in singly charged calcium were performed using the newly developed violet diode laser operated in an external cavity arrangement. The laser was employed on stored ions at the CRYRING facility to optically pump the resonance line at 397 nm. In combination with laser probing at 866 nm this detection scheme gave the possibility to record the l

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Denna artikel är en studie av den narrativa metalepsen i två skilda sammanhang: Unamunos roman "Dimma", som publicerades i Spanien i början av 1900-talet, och Chamoiseaus roman "Biblique des derniers gestes", som publicerades i Frankrike på 2000-talet. Studien visar hur användningen av den narrativa metalepsen förändrats under den period på ett hundra år som skiljer de två romanerna, samtidigt somThis article is a study of the metalepsis in two different contexts: Unamuno's novel "Fog", published in Spain at the beginning of the 20th century, and Chamoiseau's novel "Biblique des derniers gestes", published in France in the 21st century. The study shows how the use of narrative metalepsis has changed during the period of one hundred years that separates the novels, but also some surprising

Vocational assessment and intervention for people with epilepsy

Employment restrictions have been experienced by many people with epilepsy. In many cases, the restrictions are unjustified and based on stigma or a stereotypical image of the person with epilepsy. Unjustifiable restrictions are a form of discrimination and lead to unemployment and underemployment. Unfortunately, much of the research in this area has been difficult to interpret because of differen

T cell surface redox levels determine T cell reactivity and arthritis susceptibility.

Rats and mice with a lower capacity to produce reactive oxygen species (ROS) because of allelic polymorphisms in the Ncf1 gene (which encodes neutrophil cytosolic factor 1) are more susceptible to develop severe arthritis. These data suggest that ROS are involved in regulating the immune response. We now show that the lower capacity to produce ROS is associated with an increased number of reduced

Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration

The rd3 mouse is one of the oldest identified models of early-onset retinal degeneration. Using the positional candidate approach, we have identified a C -> T substitution in a novel gene, Rd3, that encodes an evolutionarily conserved protein of 195 amino acids. The rd3 mutation results in a predicted stop codon after residue 106. This change is observed in four rd3 lines derived from the original

Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: A report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group

Purpose Earlier studies have shown that endogenous gonadal hormones play an important role in the etiology of breast cancer among BRCA1/ 2 mutation carriers. So far, little is known about the safety of exogenous hormonal use in mutation carriers. In this study, we examined the association between oral contraceptive use and risk of breast cancer among BRCA1/ 2 carriers. Patients and Methods In the

Social support at work and the risk of myocardial infarction and stroke in women and men.

It has been proposed that lack of social support in a work place characterized by high levels of stress, may increase the likelihood of future cardiovascular disease. The aim of this study was to analyze the prospective impact of social support at work in combination with self-reported work stress on incidence of myocardial infarction (MI) and stroke in a cohort of 4707 women (mean age: 54.2 years