Relatives of cancer patients are at an increased risk of the same (concordant) cancer but whether they are at a risk for different (discordant) cancers is largely unknown - beyond well characterized hereditary cancer syndromes - but would be of major scientific and clinical interest. We therefore decided to resolve the issue by analyzing familial risks when family members were diagnosed with any d

This paper investigates the effect of the presence of a rib on the end-wall heat transfer of an obstacle by liquid crystal thermography. An obstacle with a rectangular cross section is placed in a rectangular channel and blocks the entire height of it (AR = 4). A rib with a square cross section is placed at two positions, i.e., in the upstream and downstream areas of the obstacle, respectively. An

Background: Collection and testing of individual serum samples are often used in research to gain knowledge about e.g. the humoral response against bacteria or virus. This is a valid but time-consuming method and might be a waste of valuable serum samples for inefficient research. So far, no study has considered using serum pools as a quick and efficient screening method to confirm or deny hypothe

MAX IV is presently under construction at Lund, Sweden, and the first beam for the production of synchrotron radiation is expected to circulate in 2016. The whole set of 3 GeV ring beam pipes is coated with Ti-Zr-V Non Evaporable Getter (NEG) thin film in order to fulfil the average pressure requirement of 1×10-9 mbar, despite the compact magnet layout and the large aspect ratio of the vacuum cham

A new global atmospheric carbon dioxide (CO2) real-time forecast is now available as part of the pre- operational Monitoring of Atmospheric Composition and Climate – Interim Implementation (MACC-II) service us- ing the infrastructure of the European Centre for Medium- Range Weather Forecasts (ECMWF) Integrated Forecast- ing System (IFS). One of the strengths of the CO2 fore- casting system is that

Objective: To describe the electrophysiological characteristics and pathophysiological significance of electrographic status epilepticus (ESE) after cardiac arrest and specifically compare patients with unequivocal ESE to patients with rhythmic or periodic borderline patterns defined as possible ESE. Methods: Retrospective cohort study of consecutive patients treated with targeted temperature mana

A 7-year-old boy with recurrent pneumonia of the right lower lobe is described. At bronchoscopy a small tumour almost totally obliterating the right lower lobe was detected. Surgical treatment was undertaken. Histopathologic studies showed findings consistent with those of a muco-epidermoid tumour. The case emphasizes bronchoscopy as an important investigation in children with recurrent pneumonia.

Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we

Prostate cancer is the most common form of cancer in Sweden. The past decade has seen a tremendous development of new methods for diagnosing, staging, treating and rehabilitating men with suspicious or confirmed prostate cancer. This development necessitates a multidisciplinary and multiprofessional approach to the management of men with suspicious or confirmed prostate cancer. A recent survey sho

Background: Whole-cell biocatalysis based on metabolically active baker's yeast with engineered transamination activity can be used to generate molecules carrying a chiral amine moiety. A prerequisite is though to express efficient ω-transaminases and to reach sufficient intracellular precursor levels. Results: Herein, the efficiency of three different ω-transaminases originating from Capsicum chi

Birds migrating between distant locations regularly perform long continuous flights lasting several days. What compass mechanism they use is still a mystery. Here, we use a novel approach, applying an individual-based model, taking compass mechanisms based on celestial and geomagnetic information and wind into account simultaneously, to investigate what compass mechanism likely is used during long

We present an optimization procedure that mixes advanced large-scale optimization methods and heuristics to solve large instances (with over 1.7 million integer variables) of the routing and spectrum allocation (RSA) problem - a basic optimization problem in flexgrid elastic optical networks. We formulate the problem as a mixed-integer program for which we develop a branch-and-price algorithm enha

Bats are currently killed in large numbers at wind turbines worldwide, but the ultimate reason why this happens remains poorly understood. One hypothesis is that bats visit wind turbines to feed on insects exposed at the turbine towers. We used single molecule next generation DNA sequencing to identify stomach contents of 18 bats of four species (Pipistrellus pygmaeus, Nyctalus noctula, Eptesicus

Municipal wastewater treatment plants are constantly forced to make improvements. The main objectives are to reduce energy consumption, to increase the treatment capacity and to improve the effluent water quality. Microsieves in combination with chemical pretreatment can potentially fulfil these objectives. In this work, experiments were mainly conducted at the large pilot scale, and supplementaryMunicipal wastewater treatment plants are constantly forced to make improvements. The main objectives are to reduce energy consumption, to increase the treatment capacity and to improve the effluent water quality. Microsieves in combination with chemical pretreatment can potentially fulfil these objectives. In this work, experiments were mainly conducted at the large pilot scale, and supplementary

A new large igneous province (LIP), the 1501 ± 3 Ma Kuonamka LIP, extends across 700 km of northern Siberia and is linked with coeval dikes and sills in the formerly attached Sao Francisco craton (SFC)-Congo craton to yield a short-duration event 2000 km across. The age of the Kuonamka LIP can be summarized as 1501 ± 3 Ma (95% confidence), based on 7 U-Pb ID-TIMS ages (6 new herein) from dolerite

Empathy concerns the feeling of understanding others’ experiences from their perspective, and confronts you with the presence of a qualitative experience that you are not living through yourself. In aesthetics empathy has been conceived as bodily inner imitation. Taking a theoretical, interdisciplinary approach that merges insights from psychology, philosophy, and phenomenology within the dynamic

Complete wetting is crucial for efficient recombination of powders. On the powder bed scale, wetting is governed solely by capillary forces and the resistance to flow, i.e. spontaneous imbibition. Slow or incomplete imbibition of the powder bed may lead to gelling of the liquid front, which will stop the recombination process and cause the formation of lumps, which is usually undesirable. In this

Growing planets interact with their natal protoplanetary disc, which exerts a torque onto them allowing them to migrate in the disc. Small mass planets do not affect the gas profile and migrate in the fast type-I migration. Although type-I migration can be directed outwards for planets smaller than 20−30M⊕ in some regions of the disc, planets above this mass should be lost into the central star lo