Popular Abstract in Swedish Många cancerceller har ovanligt höga nivåer av proteinet DEK och i vissa fall av leukemi har man hittat en genetisk förändring som leder till en variant kallad DEK-NUP214. Man tror därför att DEK kan vara en av faktorerna som bidrar till att vanliga celler omvandlas till cancerceller. En sådan roll har visats i experimentella modeller där man även sett att cancerceller The DEK gene is upregulated in a growing number of cancers and translocated to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. In this thesis, we studied the cellular and molecular functions of the DEK and DEK-NUP214 proteins. We found that the expression of DEK is increased by the leukemia-associated fusion protein NUP98-HOXA9, suggesting that DEK may be a downstream mediat

We present a noninvasive optical method to determine the local strain in individual semiconductor nanowires. InP nanowires were intentionally bent with an atomic force microscope and variations in the optical phonon frequency along the wires were mapped using Raman spectroscopy. Sections of the nanowires with a high curvature showed significantly broadened phonon lines. These observations together

Fucoxanthin-chlorophyll protein (FCP) is the key molecular complex performing the light-harvesting function in diatoms, which, being a major group of algae, are responsible for up to one quarter of the total primary production on Earth. These photosynthetic organisms contain an unusually large amount of the carotenoid fucoxanthin, which absorbs the light in the blue-green spectral region and trans

A study is presented about the effects of three glazing colour types (blue, neutral, bronze) on daylight quality, arousal and switch-on patterns for electric lights. This study was carried out using a scale model (1:4) of an office room, where subjective evaluations of the luminous conditions were performed by 36 participants (mean age 23.8 years) with their upper bodies immersed in the model. The

Osteoblastoma is a bone forming tumor with histological features highly similar to osteoid osteoma; the discrimination between the tumor types is based on size and growth pattern. The vast majority of osteoblastomas are benign but there is a group of so-called aggressive osteoblastomas that can be diagnostically challenging at the histopathological level. The genetic aberrations required for osteo

The purpose of the study was to develop a method for analysis of diffusion parameters along white matter (WM) tracts, using spatial normalization based on anatomical landmarks, and to introduce the apparent area coefficient (AAC). The method's applicability was tested in the inferior fronto-occipital fasciculus (IFO) in patients with progressive supranuclear palsy (PSP) and healthy controls (HCs).

Recension av Jens Ljunggren; Inget land för intellektuella. 68-rörelsen och svenska vänsterintellektuella.

This article reviews our work on the description of electronic transport through self-assembled quantum dots. Our main interest is in the effect of Coulomb interaction on quantum dot charging (capacitance-voltage characteristics), on the average current (current-voltage characteristics), and on current fluctuations (quantum shot noise) in quantum dot layers embedded in pn- or resonant tunneling de

A short and efficient total synthesis of rac-desoxygaliellalactone and (+)-desoxygaliellalactone, via the biosynthetic intermediate pregaliellalactone, is described. The synthesis was achieved in only three steps, for (+)-desoxygaliellalactone including an enantioselective alkyl propiolate addition to 4-pentenal, a palladium catalysed alkylative lactonisation and an intramolecular Diels-Alder cycl

Popular Abstract in Swedish Den här avhandlingen innehåller fyra uppsatser som på ett eller annat sätt relaterar till befolkningsströmningar såsom dess ekonomiska konsekvenser och orsaker. I den första uppsatsen används en hushållsundersökning från Kina för att undersöka huruvida utbildning bidrar till att höja inkomsterna hos hushåll i jordbrukssektorn. Genom regressionsanalys uppmäts korrelatioAbstract Population movements are more substantial today than at any other point in human history. If managed effectively, migration can be beneficial for all aspects of social and economic life. This thesis contains four papers, all of which are related to the economic consequences and determinants of migration, within and across countries. The first paper employs a household survey to explore

Current response and gain spectrum of a terahertz quantum cascade laser is analyzed at different temperatures by a nonequilibrium Green's functions approach. The simulations are compared to recent results of time domain spectroscopy. Being able to retrieve higher harmonics of the response function, nonlinear phenomena in quantum cascade lasers are studied theoretically. For different temperatures,

The objective of this paper is to provide a general account of value relations. But it takes its departure is a special type of value relation, parity. The notion of parity is due to Ruth Chang. According to her, two items may be evaluatively comparable even when neither is better than, worse than, or equally good as the other. There is a fourth kind of comparability: being on a par. Recently, Jos

Using constant-effort catch data, causes of annual variation in the timing of migration of Curlew Sandpipers (Calidris ferruginea) migrating through Ottenby, Sweden, as well as the trend in timing of migration from 1946-2005, was investigated. Variation in the timing of autumn migration of adult and juvenile Curlew Sandpipers was influenced by breeding success connected to predation pressure on th

Using the Swedish military enlistment test, this paper estimates the return to schooling for individuals belonging to different parts of the ability distribution. It also attempts to predict whether an endogenous test score causes bias in the "ability-specific" returns to schooling that varies with the test score. A significant finding is that a higher score in the test is associated with a higher

This paper examines Sweden’s role as a pioneer in mitigating climate change. Critical discourse analysis of climate and energy policy unveils Sweden’s ambition to ‘lead-by-example’, by virtue of a win-win combination of economy and environment via stringent regulations and an early-mover strategy on eco-innovations. The extent of the unilateral approach is constrained by concerns for the competiti

The epidermal growth factor receptor (EGFR) and the estrogen receptor (ER) modulator Amplified In Breast cancer-1 (AIB1) have been reported to be of importance for the prognosis of breast cancer patients. We have analyzed AIB1 and EGFR by immunohistochemistry in primary breast cancers (n = 297) arranged in a tissue microarray in order to predict outcome after adjuvant endocrine therapy with tamoxi

This thesis measures cost efficiency in the production of health care and social services in Sweden. The object of analysis is not provider efficiency, but instead the relative efficiency of political organizations or different contractual arrangements. The thesis focuses on: 1) the measurement of cost efficiency, 2) the investigation of potential trade-offs between quantity of health care service