Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do n

Respiratory mechanics, using flow interruption, was previously studied during the complete breath in healthy ventilated man, numerical techniques relieving constraints regarding flow pattern. The classical linear model of non-Newtonian behaviour was found to be valid. The present study was extended to subjects with critical lung disease. Subjects with acute lung injury (ALI; n = 2), acute respirat

This paper aims to discuss street art as new form of art and activism of uncomissioned and unsanctioned artifacts including paintings, murals and various kinds of stencils, posters, and stickers applied in any public surface. As Bengtsen (2014) has argued street art is a sociocultural practice, which is performative, ephemeral, and site specific. Street art has much to tell us about the dialectics

We describe a series of microcalorimeter X-ray spectrometers designed for a broad suite of measurement applications. The chief advantage of this type of spectrometer is that it can be orders of magnitude more efficient at collecting X-rays than more traditional high-resolution spectrometers that rely on wavelength-dispersive techniques. This advantage is most useful in applications that are tradit

Introduction: Resistance to antiretroviral drugs can complicate the management of HIV-1 infection and impair control of its spread. The aim of the current study was to investigate the prevalence and transmission of HIV-1 drug resistance among 106 antiretroviral therapy (ART)-naïve patients diagnosed in Iceland (1996–2012).Methods: HIV-1 polymerase sequences were analysed using the Calibrated Popul

While comparative construal (categorization, analogy and metaphorization) has been the subject of considerable research in linguistics, psychology, and cognitive science, comparatively little attention has been given to its role in emotive and sensory knowledge transfer (Thagard & Shelley 2006: 27). This paper proposes an explanatory framework for comparative construal in the form of a three-d

The sense of touch is fundamental for daily behavior. The aim of this work is to understand the neural network responsible for touch processing during a prolonged tactile stimulation, delivered by means of a mechatronic platform by passively sliding a ridged surface under the subject’s fingertip while recording the electroencephalogram (EEG). We then analyzed: (i) the temporal features of the Soma

Direct searches for lepton flavour violation in decays of the Higgs and Z bosons with the ATLAS detector at the LHC are presented. The following three decays are considered: H→ eτ, H→ μτ, and Z→ μτ. The searches are based on the data sample of proton–proton collisions collected by the ATLAS detector corresponding to an integrated luminosity of 20.3 fb - 1 at a centre-of-mass energy of s=8 TeV. No

A measurement of the tt¯ Z and tt¯ W production cross sections in final states with either two same-charge muons, or three or four leptons (electrons or muons) is presented. The analysis uses a data sample of proton–proton collisions at s=13 TeV recorded with the ATLAS detector at the Large Hadron Collider in 2015, corresponding to a total integrated luminosity of 3.2 fb- 1. The inclusive cross se

Maritime operations are complex socio-technical activities, with many interacting agents. Such agents are acting based on different, sometimes conflicting, goals. The traditional approach for safety, based on decomposition and bimodality, might lead to ineffective analyses, ignoring the transient and hidden links among activities as they are performed in everyday work. In this sense, the Functiona

This book probes the relationship between Martin Heidegger and theology in light of the discovery of his Black Notebooks, which reveal that his privately held Antisemitism and anti-Christian sentiments were profoundly intertwined with his philosophical ideas. Heidegger himself was deeply influenced by both Catholic and Protestant theology. This prompts the question as to what extent Christian anti

Development of optical techniques in medical applications can be difficult due to limited access to realistic phantoms. Here a 3-D printed model based on CT-images of the thorax of an infant is developed and tested.

Assessment of programmed cell death ligand 1 (PD-L1) immunohistochemical staining is used for decision on treatment with programmed cell death 1 and PD-L1 checkpoint inhibitors in lung adenocarcinomas and squamous cell carcinomas. This study aimed to compare the staining properties of tumor cells between the antibody clones 28-8, 22C3, SP142, and SP263 and investigate interrater variation between

In this paper we call into question the relationship between development, inequality and territory in the current context of globalization and within the framework of public policies designed, supposedly, to benefit those social actors with fewer resources. In order to do this, we focus on a case study in the northeast of the province of Misiones, Argentina. Here tobacco production, forestry and a

In diverse countries of the continent, environmental transformations -and the injustices connected- have traditionally been studied in the case of extractive industries, such as mining, oil or agriculture. However, in the present study we want to discuss these concerns in the context of mega-projects that are commonly considered part of a “sustainable development”. Renewable, clean or green techno

Knowledge of the material in the ATLAS inner tracking detector is crucial in understanding the reconstruction of charged-particle tracks, the performance of algorithms that identify jets containing b-hadrons and is also essential to reduce background in searches for exotic particles that can decay within the inner detector volume. Interactions of primary hadrons produced in pp collisions with the

Succinate:quinone reductase catalyzes electron transfer from succinate to quinone in aerobic respiration. Carboxin is a specific inhibitor of this enzyme from several different organisms. We have isolated mutant strains of the bacterium Paracoccus denitrificans that are resistant to carboxin due to mutations in the succinate:quinone reductase. The mutations identify two amino acid residues, His228