Sökresultat
Filtrera
Filtyp
Din sökning på "*" gav 532057 sökträffar
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mu
Pathway and network analysis of more than 2500 whole cancer genomes
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole g
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive tumorigenesis, and whether such functions could be conserved during evolution. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we introduce th
Humanitas : Universalism, equivocation, and basic criterion
The Bug Show : Co-production of knowledge on health and medicine for yung audiences in Sweden
Reaktorhallen: Violin Solo
In 2021, I had a residency in "Reaktorhallen" (The Reactor Hall, or "R1"), a former nuclear reactor hall on the campus of Kunliga Tekniska Högskolan (the Royal Institute of Technology, or "KTH"). I was there to make a work for the Skandia organ, a former cinema organ that is housed in R1. I also worked with the violin in the space, and played an improvisation from this material on the concert I di
Acute burn care and outcomes at the Hospital Nacional Guido Valadares (HNGV), Timor-Leste : A 7-year retrospective study
The purpose of this study was to describe the epidemiology of patients presenting with acute burns and undergoing admission at Hospital Nacional Guido Valadares (HNGV) in Dili, Timor-Leste in the period 2013 to 2019. HNGV is the only tertiary referral hospital in Timor-Leste. This was a retrospective study involving all acute burn patients admitted to the surgical wards of HNGV from 2013 to 2019.
Judges under Pressure
Tracking structural solvent reorganization and recombination dynamics following e-photoabstraction from aqueous I-with femtosecond x-ray spectroscopy and scattering
We present a sub-picosecond resolved investigation of the structural solvent reorganization and geminate recombination dynamics following 400 nm two-photon excitation and photodetachment of a valence p electron from the aqueous atomic solute, I-(aq). The measurements utilized time-resolved X-ray Absorption Near Edge Structure (TR-XANES) spectroscopy and X-ray Solution Scattering (TR-XSS) at the Li
Navigating the Gray Zones of International Research
Science funders can enable responsible international collaboration by developing global norms for ethical research that appropriately respond to today’s geopolitical tensions.
Steel decarbonization in China–a top-down optimization model for exploring the first steps
The steel industry is a major contributor to emissions of CO2 and key air pollutants. Reducing air pollution has since long been a policy priority in China. Reducing CO2 emissions has more recently also become a key priority partially manifested through the signing of the Paris Agreement in 2015. Although there are often synergies between reducing CO2 emissions and air pollution, it may have impli
Milk intake, lactase persistence genotype, plasma proteins and risks of cardiovascular events in the Swedish general population
To investigate the associations of milk intake (non-fermented and fermented milk), lactase persistence (LCT-13910 C/T) genotype (a proxy for long-term non-fermented milk intake), and gene-milk interaction with risks of cardiovascular disease (CVD) and CVD mortality. Also, to identify the CVD-related plasma proteins and lipoprotein subfractions associated with milk intake and LCT-13910 C/T genotype
Characterization of the degree of food processing in the European Prospective Investigation into Cancer and Nutrition : Application of the Nova classification and validation using selected biomarkers of food processing
BACKGROUND: Epidemiological studies have demonstrated an association between the degree of food processing in our diet and the risk of various chronic diseases. Much of this evidence is based on the international Nova classification system, which classifies food into four groups based on the type of processing: (1) Unprocessed and minimally processed foods, (2) Processed culinary ingredients, (3)
Planned meetings : Multiplicity, boxed-in dialogues, and deliberative bureaucracy as social form
In what ways are meetings a social form? How are meetings organized and how do organizations structure meetings to produce consensus around visions of the future? In this article, planning meetings, which gather representatives from the regional Public Transport Authority and the municipalities involved in public transport planning in Stockholm, Sweden, is probed as a social form. By structuring t
The Epistemology of the Homecoming : Language, Culture, and Knowledge in Ludvig Holberg's Erasmus Montanus
Histopathological dimensions differ between aganglionic and ganglionic bowel wall in children with Hirschsprung’s disease
Background: In the validation of new imaging technology for children with Hirschsprung’s disease (HSCR), basic anatomical parameters of the bowel wall must be established specifically for this patient group. Aim: To explore differences in histoanatomical layers of bowel wall, comparing ganglionic and aganglionic bowel walls, and to examine if the bowel wall thickness is linked to patient weight. M
When Blood Pressure Increases with Standing : Consensus Definition for Diagnosing Orthostatic Hypertension
Cardiovascular autonomic abnormalities in patients with Post-acute Sequalae of COVID-19 : don't miss that target!
OpenChart-SE: A corpus of artificial Swedish electronic health records for imagined emergency care patients written by physicians in a crowd-sourcing project
Electronic health records (EHRs) are a rich source of information for medical research and public health monitoring. Information systems based on EHR data could also assist in patient care and hospital management. However, much of the data in EHRs is in the form of unstructured text, which is difficult to process for analysis. Natural language processing (NLP), a form of artificial intelligence, h