Quinoline-3-carboxamides modulate primary T cell-dependent B cell responses but do not inhibit functional immunity.
The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal center B cells and follicular T cells in the spleen up to 21 days after immunization. Als