This article addresses a classical question: Can a machine use language meaningfully and if so, how can this be achieved? The first part of the paper is mainly philosophical. Since meaning implies intentionality on the part of the language user, artificial systems which obviously lack intentionality will be `meaningless' (pace e.g. Dennett). There is, however, no good reason to assume that intenti

This paper presents a study of the role that photography of 14 October 1973 and 6 October 1976 has played in political mobilization around the two events. It is well known that in official archives limited versions of the events can be found. We must turn to alternative repositories (private homes, non­states organisations, but also universities and libraries outside of Thailand) to find the antic

The environment of the Tibetan Plateau (TP) is regarded as one of the most sensitive ecosystems of the world. However, investigations on effects caused by global climate change or anthropogenic activities are rare due to its quite remote location. This thesis deals with various aspects of the carbon and water cycle within ecological and hydrological studies that can be assessed by measurements of

In the brain, focal ischemia results in a local region of cell death and disruption of both local and remote functional neuronal networks. Tissue reorganization following stroke can be limited by factors such as extracellular matrix (ECM) molecules that prevent neuronal growth and synaptic plasticity. The brain's ECM plays a crucial role in network formation, development, and regeneration of the c

Background: Open repair (OR) for popliteal artery aneurysm (PAA) has recently been challenged by endovascular repair (ER) as the primary choice of treatment. The aim of the present study was to evaluate time trends in treatment modality and compare outcomes between OR and ER among electively operated patients after start of screening in 2010 for abdominal aortic aneurysm (AAA), a disease highly as

Aim: The Swedish Social Board has implemented a support strategy to guide out-of-home care for children, which translates as children's needs in focus (CNIF) and includes a systematic health assessment. It was fully introduced into the Skåne province in 2012 and our study covered the first four years of the CNIF health assessments, from 2012 to 2015. Methods: We studied children aged 0–17 years in

BACKGROUND: Many lifestyle factors have been associated with the metabolic syndrome (MetS). However, most of these studies have not considered the potential impact of obesity and have often only investigated one lifestyle factor at the time. We aimed to investigate the interplay between body mass index (BMI) and MetS with respect to multiple lifestyle factors.METHODS: BMI and MetS [National Choles

Chondroitin sulfate (CS)/dermatan sulfate (DS) proteoglycans are abundant on the cell surface and in the extracellular matrix and have important functions in matrix structure, cell-matrix interaction and signaling. The DS epimerases 1 and 2, encoded by Dse and Dsel, respectively, convert CS to a CS/DS hybrid chain, which is structurally and conformationally richer than CS, favouring interaction wi

The rock-cut chamber tombs form a very small percentage of the rockcut tombs in Labraunda. The majority of these tombs, situated next to the sanctuary, were studied by Paul Åström in 1950 together with the sarcophagi; two improved from natural caves further from the sanctuary in both directions were found in a topographic survey conducted by Lars Karlsson in 2005, and finally one tomb at some dist

It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and whether it can initiate signaling is unclear. Using structural and biophysical analysis, we show that the extracellular region of CD45 is rigid and extends beyond the distance spanned by TCR-ligand complexes, implying t

Det verkar som att många politiker nästan hyser en outtalad irritation över att det ska vara så svårt för nyanlända att ­lära sig svenska. Men det kan vara mycket svårt att lära sig ett nytt språk, och det måste ibland få ta tid – även för inlärare som ­anstränger sig hårt, skriver Gunlög Josefsson, professor i svenska.