Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk

The research aims to language analysis of the Arab critical speech, which dealt with the study of narrative, in the theoretical and practical side, using pragmatic mechanisms, including holdings of terms, and effective tools in linguistic studies. It’s the starting point for many of the process of modern literary criticism. The study has taken two ways: first, the side of theoretical through summa

A search is presented for new resonances decaying to a W or Z boson and a Higgs boson in the ℓ+ℓ−bb¯, ℓνbb¯, and νν¯bb¯ channels in pp collisions at s=13 TeV with the ATLAS detector at the Large Hadron Collider using a total integrated luminosity of 3.2 fb−1. The search is conducted by looking for a localized excess in the WH/ZH invariant or transverse mass distribution. No significant excess is o

Parkinson's disease (PD) is a common, progressive neurodegenerative disorder associated with a loss of dopaminergic cells in the substantia nigra pars compacta and a lack of dopamine in the striatum. To halt or reverse this disease, neurorestorative approaches or neuroprotective treatments are urgently needed. Recently, the first clinical trials transplanting mesenchymal stem cells (MSCs) have bee

IL-1β release is integral to the innateimmunesystem.The release ofmature IL-1βdepends on 2 regulated events: the de novo induction of pro-IL-1β, generally via NF-κB-dependent transduction pathways; and the assembly and activation of the NLRP3 inflammasome. This latter step is reliant on active caspase-1, pannexin-1, and P2X7 receptor activation. Pathogen-associated molecular patterns in gram-posit

This study investigated the interplay between nursing staff stress, Mastery, Moral Sensitivity, individual characteristics and the ward atmosphere in psychiatric in-patient care. Data were collected through five questionnaires from 93 nursing staff. Multivariate analysis showed that Moral Strength, Moral Burden, Internal Demands, Perceived Stress and age were related to several factors of the ward

BACKGROUND: Chronic lung allograft dysfunction in the form of bronchiolitis obliterans syndrome (BOS) is the main cause of death beyond 1-year post-lung transplantation. The disease-initiating triggers as well as the molecular changes leading to fibrotic alterations in the transplanted lung are largely unknown. The aim of this study was to identify potential early changes in the extracellular matr

IMPORTANCE: Little is known about whether the duration of adjuvant imatinib influences the prognostic significance of KIT proto-oncogene receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor α (PDGFRA) mutations. OBJECTIVE: To investigate the effect of KIT and PDGFRA mutations on recurrence-free survival (RFS) in patients with gastrointestinal stromal tumors (GISTs) treated wi

A survey was made of the current status of treatment of haemophilic boys at 20 centres in 16 European countries and includes approximately 1500 of the estimated 6500 haemophiliacs in the participating countries. Many mild haemophiliacs are not seen, or seen infrequently, at haemophilia centres and this requires study. Nine of 18 centres provide continuous prophylaxis to 80-100% of their patients,

The equilibrium and kinetics of the furan-maleimide Diels-Alder (DA) reaction for the formation of a reversible network were studied by calorimetry between 25 °C and 90 °C using an amorphous bismaleimide eliminating solvent use. The relationship between the equilibrium conversion xeq with temperature and the effect of dilution were simulated. The glass transition-conversion relationship of the rev

The histone methyltransferase EZH2 is required for B and T cell development; however, the molecular mechanisms underlying this requirement remain elusive. In a murine model of lymphoid-specific EZH2 deficiency we found that EZH2 was required for proper development of adaptive, but not innate, lymphoid cells. In adaptive lymphoid cells EZH2 prevented the premature expression of Cdkn2a and the conse

The aim is to explore the absence or presence of, and motives for, research at centers for academic development and to problematize the research situation among academic developers. Boyer’s and Healey’s theories are used as lenses for the analysis based on the questionnaires that were used for data collection. The conclusion is that research is a challenging and sensitive area for university cente

This report, commissioned by the Governing Board’s working group on volunteering and the secretariat of the International Federation of Red Cross and Red Crescent societies, aims to provide a picture of volunteering development since 1999 across the globe. It provides a broad outline of decision-making and commitments within the International Federation and describes the situation in National Soci

Image quality assessment (IQA) plays an important role in quality monitoring, evaluation and optimization for image processing systems. However, current quality-Aware feature extraction methods for IQA can hardly balance accuracy and complexity. This paper introduces multi-order local description into image quality assessment for feature extraction. The first-order structure derivative and high-or

The dijet production cross section for jets containing a b-hadron (b-jets) has been measured in proton–proton collisions with a centre-of-mass energy of s=7 TeV, using the ATLAS detector at the LHC. The data used correspond to an integrated luminosity of 4.2fb-1. The cross section is measured for events with two identified b-jets with a transverse momentum pT> 20 GeV and a minimum separation in th