Background: Single-nucleotide polymorphisms in genes involved in pain control might predispose to exaggerated sensitivity or difference in opioid analgesic effect. The relevance of the KCNJ6 -1250G>A (rs6517442, c.-1787G>A) and the catecholamine-O-methyltransferase (COMT) c.472G>A (rs4680, Val 158 Met) single-nucleotide polymorphisms were studied in preterm infants needing intubation and randomize

As the quest for knowledge translation from research to practice and policy contexts is growing stronger, researchers need to develop strategies for synthesizing research findings. Since home environments constitute an important context for the delivery of health care and social services to older adults and people aging with disabilities, research in this field can serve as an example for such end

In the wake of the economic and social crisis, Spanish fiction has looked for ways of reflecting (on) the political. One of the manners has been to attempt to understand how the crisis has affected subjectivity and, more concretely, how the subject navigates the society of the crisis. In this article, I study three recent novels—Alberto Olmos’ Ejército enemigo (2011), Bruno Galindo’s El público (2

A partir del fin de la Segunda Guerra Mundial se extiende, partiendo de los EEUU, una comprensión y uso de la ciencia subordinadas al proceso de producción. Esto determina el avance, sobre el campo científico, de un proceso de administración de la investigación y de la formación por parte del Estado y, a través de él, del aparato productivo. Esa subordinación de la actividad científica a la utilid

Gaia is a cornerstone mission in the science programme of the European Space Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which th

We measure spectrally and spatially resolved high-order harmonics generated in argon using chirped multi-cycle laser pulses. Using a stable, high-repetition rate laser we observe detailed interference structures in the far-field. The structures are of two kinds; off-axis interference from the long trajectory only and on-axis interference including the short and long trajectories. The former is rea

This study focuses on Muslim fertility in Europe. Evidence from 25 countries suggests that the Muslim total fertility rate is on average 47% higher than the national level. However, we find a significant difference in the level of fertility of native-born Muslims and immigrant Muslims. The native-born have a 19% higher total fertility rate, while immigrants have 62% higher fertility. Our main rese

Variables measured in modern pulse oximetry apparatuses include a graphic pulse curve and a specified perfusion value (PV) that could be a sensitive marker for detecting differences in sympathetic activity. We hypothesized that there is a correlation between a reduction of PV and the time to eye opening after anesthesia with propofol-remifentanil. This study includes 29 patients, ASA physical stat

We consider dynamic optimization problems for systems described by differential-algebraic equations (DAEs). Such problems are usually solved by discretizing the full DAE. We propose techniques to symbolically eliminate many of the algebraic variables in a preprocessing step before discretization. These techniques are inspired by the causalization and tearing techniques often used when solving DAE

A three bit second order delta sigma modulator for audio applications implemented in 130nm CMOS technology is presented. The modulator features two integrators, a flash quantizer and two current steering DACs. In order to minimize the effect of delays in the DACs, excessive loop delay (ELD) compensation is utilized. Using an oversampling ratio (OSR) of 80, the design consumes 2.8mW and achieves a

A simple form for the optimal H-infinity state feedback of linear time-invariant infinite-dimensional systems is derived. It is applicable to systems with bounded input and output operators and a closed, densely defined, self-adjoint and strictly negative state operator. However, unlike other state-space algorithms, the optimal control is calculated in one step. Furthermore, a closed-form expressi

Africa is a sink of carbon, but there are large gaps in our knowledge regarding the CO2 exchange fluxes for many African ecosystems. Here, we analyse multi-annual eddy covariance data of CO2 exchange fluxes for a grazed Sahelian semi-arid savanna ecosystem in Senegal, West Africa. The aim of the study is to investigate the high CO2 exchange fluxes measured at the peak of the rainy season at the Da

Sustainable and efficient management of a distribution system requires coordination between transportation planning and inventory control decisions. In this context, we consider a one warehouse multi-retailer inventory system with a time-based shipment consolidation policy at the warehouse. This means that there are fixed costs associated with each shipment, and retailer orders are consolidated an

CO oxidation over Pd(100) and Pd75Ag25(100) has been investigated by a combination of near-ambient-pressure X-ray photoelectron spectroscopy, quadrupole mass spectrometry, density functional theory calculations, and microkinetic modeling. For both surfaces, hysteresis is observed in the CO2 formation during the heating and cooling cycles. Whereas normal hysteresis with light-off temperature higher