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Autoantibodies to GAD65 (GAD65Ab) are prominent in type 1 diabetes. These autoantibodies may be present both years before and after the clinical diagnosis of type 1 diabetes and are widely used as a marker for the disease. Recently it has been demonstrated that progression to type 1 diabetes is accompanied by GAD65Ab epitope maturation. Here we examine whether autoantibody maturation processes als
The ontology of Rāmānuja, as expressed in his Gītābhāṣya and other works, centres on the doctrine of coordinate predication (sāmānādhikaraṇya), expressed through the metaphor of the self-body relationship (ātma-śarīra-bhāva). This metaphor, employed to define the ontological status of God (Nārāyaṇa), the individual selves and the world, also serves as a strategy for reconciling apparently conflict
Popular Abstract in Swedish Cytokromer bär hem som prostetisk grupp och ingår i den energi givande andningskedjan. Cytokromer namnges beroende på strukturen av den hem-molekyl som respektive cytokrom bär. Cytokrom av a-typ innehåller hemA, cytokrom av b-typ innehåller hemB osv. Cytokrom av c-typ skiljer sig från övriga cytokrom genom att ha hemgruppen kovalent bunden till proteinet. Syntes av baktCytochromes function in electron transfer reactions, e.g. in respiratory systems, and contain haem as a prosthetic group. Cytochromes of the c-type differ from other cytochromes in that haem is covalently attached, via thioether linkages, to two cysteine residues in a conserved sequence motif in the protein, Cys-Xaa-Yaa-Cys-His. The functional location of c-type cytochromes in bacteria is on the o
Popular Abstract in English A handful of diseases-causing pathogenic microorganisms claim millions of lives worldwide each year, mainly due to limited diagnostic capabilities. The lack of simple, cost-effective, sensitive and rapid on-site diagnostic tools lead to delays in the diagnoses with a subsequent lag in treatment, which in turn can result in serious complications or even loss of lives. Fast and sensitive detection of pathogenic microbial cells is a highly important task in medical diagnostics, environmental analysis and evaluation of food safety. Accordingly, the idea of microorganism identification by the recognition of specific DNA sequence using electrochemical technique is one of the leading researches in the development of diagnostic devices. In other words, it should only
My article deals with the work of the St Joseph Sisters in the Nordic countries, particularly in Denmark and Sweden, from the sisters’ arrival in 1856 to the 1920:ies. These Catholic sisters belonged to a French congregation called "La Congregation des Sœurs de Saint-Joseph de Chambéry", which was founded at the beginning of the nineteenth century and whose motherhouse was in Chambéry in Savoy. Th
Popular Abstract in Swedish Livet uppe på en pelare År 423 e.Kr. klättrade en man som närmade sig fyrtioårsåldern upp på en pelare, för att leva resten av sitt liv på dess topp; det skulle bli nästan fyrtio år till på knappt tjugo meters höjd. Han hette Symeon och skulle redan i sin samtid bli världsberömd för sin märkliga livsstil, som den första styliten, eller pelarhelgonet. I dagens krigsdrabThe fundamental question in this work concerns the ideal relation between asceticism and society in a 5th c. writing (C.E.), the Philotheos Historia (PH), written in elaborate Greek by the learned bishop of Cyrrhus, Theodoret. This collection of saints’ stories tells about the lives of a number of ascetics who lived in the Eastern part of the Roman Empire, many of them close to Antioch. As these n
