AimReal-life studies are needed to confirm the clinical relevance of findings from randomised controlled trials (RCTs). This study aimed to assess the effectiveness and tolerability of vildagliptin add-on vs. other oral antihyperglycaemic drugs (OADs) added to OAD monotherapy in a real-life setting, and to explore the advantages and limitations of large-scale pragmatic' trials. MethodsEDGE was a p

Hip fractures are devastating for the individual and a substantial economic burden for society. The treatment for displaced femoral neck fracture is a choice between internal fixation, total hip arthroplasty and hemiarthroplasty. As a result of several randomized trials, the treatment has shifted in Sweden from mostly internal fixation towards arthroplasties. There have been concerns about long-te

We study how the k dependence in the self-energy affects the quasiparticle band structure and one-particle spectral functions. It is known that, in electron-gas-like materials, the self-energy depends significantly on k and there is a strong cancellation between the k dependence and the energy dependence of the self-energy. Analysis of the GW self-energy reveals that, even in correlated materials

Recension av National Museum of the Pacific War, museum över Stillahavskriget i Fredericksburg, Texas.

Climate change mitigation and energy security are partly interacting areas that both present future challenges. The extensive research underway within these areas is mainly conducted in separate research communities, although there are some integrative efforts. This paper examines the breadth and heterogeneity involved in treating energy security and climate change mitigation as a combined researc

Det nya handboksförslaget granskas med avseende på språk och stil och med avseende på strukturen i gudstjänsten. Flera kritiska synpunkter på språk och stil ges, och placeringen av syndabekännelsen i gudstjänstens inledning liksom placeringen av förbönen mellan predikan och nattvard kritiseras, detta med utgångspunkt från hermeneutiska insikter, och från dramaturgisk analys.

Axonal outgrowth on smooth and porous silicon surfaces was studied in organ culture. The pore size of the silicon substrata varied between 100 and 1500 nm. We found that axons preferred to grow and elongate on porous silicon surfaces only when pores of (150-500 nm) are available.

Low molecular weight heparins (LMWH's) are used to prevent and treat thrombosis. Tests for monitoring LMWH's include anti-factor Xa (anti-FXa), activated partial thromboplastin time (aPTT) and thrombin generation. Anti-FXa is the current gold standard despite LMWH's varying affinities for FXa and thrombin.

Popular Abstract in Swedish Denna avhandling syftar till att föreslå, utvärdera och applicera testprocedurer för rationalitet, svag separabilitet och effektivitet. Främst behandlas icke-parametriska så kallade ’revealed preference’ procedurer, vilka har fördelen att de, till skillnad från den parametriska ansatsen, inte behöver anslå någon funktionell form för nyttofunktionen. En majoritet av de tThis thesis aims to propose, evaluate and apply test procedures for rationality, weak separability and efficiency. In particular, it focuses on nonparametric revealed preference procedures. This approach has the advantage of not having to stipulate any functional form for the utility function, unlike the parametric approach which relies on finding a suitable functional form for the utility functio

Sophisticated statistical analyses are common in ecological research, particularly in species distribution modeling. The effects of sometimes arbitrary decisions during the modeling procedure on the final outcome are difficult to assess, and to date are largely unexplored. We conducted an analysis quantifying the contribution of uncertainty in each step during the model-building sequence to variat

The herbaceous understory forms the richest stratum in temperate broadleaved forests in terms of plant diversity. Understanding the process of understory succession is thus of critical importance for the development of management guidelines for biodiversity restoration in post-agricultural plantation forests. We studied effects of stand age, forest fragmentation, and soil and canopy conditions on

Background: A delay in surgical nerve repair results in impaired nerve function in humans, but mechanisms behind the weakened nerve regeneration are not known. Activating transcription factor 3 (ATF3) increases the intrinsic growth state of injured neurons early after injury, but the role of long-term changes and their relation to axonal outgrowth after a delayed nerve repair are not well understo

Reklamen blinkar, ljuder, ändrar färg och form. Söta djur och maskotar svischar förbi, tonas ned, dyker plötsligt upp igen. Köp, beställ, registrera dig, klicka här! Ibland skriker den högljutt. Ibland är den helt tyst, knappt synlig, svår att fånga, svår att skilja ut, men uppmuntrar till interaktion och pockar på barns uppmärksamhet. Marknadsförare är allt mer angelägna om att kommunicera med ba

The most typical enhancement for electrokinetic remediation (EKR) involves the neutralization of the alkaline front generated at the cathode by the addition of an acid to the catholyte. Although the use of strong and weak acids can be found in the literature, there is still a clear lack of reliable comparisons between them. This paper presents a comparison of the results obtained for a real lead c

The objective of this exploratory study was to develop signal processing methods for assisting in the diagnosis of arteriovenous fistula stenosis on patients suffering from end-stage renal disease and undergoing haemodialysis treatments. The proposed method is based on the classification of vessels sounds utilizing parameter extraction from wavelets transform coefficients. The coefficients energy

Popular Abstract in Swedish Joniserande strålning används ofta som behandling vid olika tumörsjukdomar i bukhåla och bäckenregion men är ibland förenad med biverkningar. Dessa kan uppkomma tidigt/akut, dvs i direkt anslutning till genomförd behandling eller sent, efter månaderår. Besvären kan vara av mycket varierande och ofta lindrig övergående karaktär såsom buksmärtor, diarré och blödningar fråGastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enteropathy. The aim of this thesis was to investigate the basic mechanisms behind leukocyte-platelet-end

The glial cell line-derived neurotrophic factor (GDNF) has an important role in neuronal survival through binding to the GFRα1 (GDNF family receptor alpha-1) receptor and activation of the receptor tyrosine kinase Ret. Transient brain ischemia alters the expression of the GDNF signaling machinery but whether the GDNF receptor proteins are also affected, and the functional consequences, have not be