1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium c

An update of the B physics performance of the ATLAS experiment is presented. After a short review of B production and decays at LHC, the main features of the ATLAS detector are described, and the present construction status is shown. Physics topics which are presented are: precision measurements, rare decays, and B production. It is shown that despite of recent changes in the trigger strategy and

This article proposes an agenda for political participation research aimed at providing empirical answers to questions derived from normative political theory. Based on a threefold distinction between responsive, participatory and deliberative models of democracy, the article first distinguishes three conceptions of political participation: as influencing attempts, as direct decision making, and a

The effects of high optical depth phenomena, such as superradiance, are investigated in potential quantum memory materials. The results may have relevance for several schemes, including controlled reversible inhomogeneous broadening, atomic frequency combs, and quantum memories based on electromagnetically induced transparency, which are based on using ensembles as storage media. It is shown that

The quality of the working environment affects the health status of a population. In the absence of government intervention this quality would be determined by market forces, but the market outcome is generally not accepted. Instead public policy attempts to carefully monitor the level of occupational hazards, which are invariably subject to regulation in industrialized countries. However, this st

PURPOSE: To investigate the effect of (191)Pt-cisplatin in vivo in terms of the antitumor effect and general toxicity on tumor-bearing nude mice. METHODS AND MATERIALS: Tumor-bearing (human squamous cell carcinoma, AB) nude mice were divided into four groups and given, i.p., physiological saline (controls), cisplatin, (191)Pt-cisplatin (80 MBq/mg), or (191)Pt-cisplatin (160 MBq/mg), respectively.

Patients with anaplastic thyroid carcinoma can rarely be cured, but every effort should be made to prevent death due to suffocation. Between 1984 and 1999, 55 consecutive patients with anaplastic thyroid carcinoma were prospectively treated according to a combined regimen consisting of hyperfractionated radiotherapy, doxorubicin, and when feasible surgery. Radiotherapy was carried out for 5 days a

The well-known side effects of antimuscarinic drugs have focused interest on other modalities of treatment of the overactive bladder. To effectively control bladder activity, identification of suitable targets for pharmacologic intervention is necessary. Such targets may be found in the central nervous system (CNS) or peripherally. Several CNS transmitters may modulate voiding, but few drugs with

We have prospectively evaluated the biologic response to desmopressin in 77 patients with type 1 von Willebrand disease (VWD) enrolled within the Molecular and Clinical Markers for the Diagnosis and Management of type 1 VWD project. Complete response to desmopressin was defined as an increase of both ristocetin cofactor activity (VWF:RCo) and factor VIII coagulant activity (FVIII:C) to 50 IU/dL or

Eighty-six patients with monosymptomatic optic neuritis of unknown cause were followed prospectively for a median period of 12.9 years. At onset, cerebrospinal fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) was establi

We investigated whether ghrelin depletion (by gastrectomy surgery) and/or treatment/replacement with the gastric hormone ghrelin alters the expression of key hypothalamic genes involved in energy balance, in a manner consistent with ghrelin's pro-obesity effects. At 2 weeks after surgery mice were treated with ghrelin (12 nmol/mouse/day, sc) or vehicle for 8 weeks. Gastrectomy had little effect on

The Loess Plateau in China constitutes in important source area for both water and sediments to the Yellow River. Thus, improved prediction techniques of rainfall may lead to better estimation of discharge and sediment content for the Yellow River. Consequently. the objective of this study was to establish better links between rainfall of the Loess Plateau in China and sea surface temperature (SST

The spectrum of singly ionized molybdenum has been recorded with Fourier transform spectrometers in the wavelength interval 1500-7000 Angstrom. We report improved energy values for a total of 330 levels, 153 even and 177 odd, which belong to the 4d(5), 4d(4)5s, 4d(3)5s(2), 4d(4)6s, 4d(4)5d, 4d(4)5p and 4d(3)5s5p configurations. 110 of the levels have been found in the present analysis. We have als

Time-series of NASA/NOAA Pathfinder AVHRR Land (PAL) data have been analysed to extract parameters describing the seasonality of vegetation in Africa. Two methods have been developed to fit smooth curves to the time-series. The first method is based on an adaptive Savitzky-Golay filtering technique, and the second on non-linear least-squares fits of asymmetric Gaussian model functions. Both proces

Protein phosphorylation and subsequent dephosphorylation was studied in digitonin-permeabilized neuroblastoma SH-SY5Y cells by measuring the incorporation of [32P]phosphate into myelin basic protein (MBP). 1,2-Dioctanoyl-sn-glycerol (DOG) and calcium synergistically induced phosphorylation of MBP, which was inhibited by the protein kinase C (PKC) pseudosubstrate peptide (PKC19-36). The phosphoryla

Rhabdomyosarcoma is a highly malignant embryonic tumor of childhood. Two specific translocations t(2;13)(q35;q14) and t(1;13)(p36;q14) have been identified in about 75-80% of ARMS cells. The aim of this multicenter study was to analyze the relationships between the identified fusion transcripts and survival including some selected clinical parameters. The extent of disease was graded according to

In this paper, a technique for calibrating a camera using a planar calibration object with known metric structure, when the camera (or the calibration plane) undergoes pure translational motion, is presented. The study is an extension of the standard formulation of plane-based camera calibration where the translational case is considered as degenerate. We derive a flexible and straightforward way

OBJECTIVE: Socioeconomic status (SES) in adulthood is known to be related to carotid atherosclerosis. However, few studies have tried to assess its association with SES from a life-course perspective. METHODS AND RESULTS: We examined the relationship between SES in childhood and in adulthood and carotid atherosclerosis in a general population of Swedish men and women. Carotid stenosis was determin

The glial cell line-derived neurotrophic factor (GDNF)-family of neurotrophic factors consisted until recently of three members, GDNF, neurturin, and persephin. We describe here the cloning of a new GDNF-family member, neublastin (NBN), identical to artemin (ART), recently published (Baloh et al., 1998). Addition of NBN/ART to cultures of fetal mesencephalic dopamine (DA) neurons increased the num

The mobility of mercury (Hg) deposited on soils controls the concentration and toxicity of Hg within soils and in nearby streams and lakes, but has rarely been quantified under field conditions. We studied the in situ partitioning of Hg in the organic top layer (mor) of podsols at two boreal forest sites differing in Hg deposition and climatic regime (S. and N. Sweden, with pollution declining to