Due to the involvement of calpains and calpastatin in the pathology of several diseases, it is important to create an analytical tool for their accurate and sensitive measurements. In this work, an amperometric immunoassay (AIA) was developed and optimized for quantification of two key proteins from the calpain proteolytic system. The detection is based on the measurement of a steady-state current

Gruppen om använder elcykel är enligt datamaterialet främst män med tillgång till bil. Innehavet är ganska jämnt fördelat över 35 år. Elcyklisterna är teknikintresserade samtidigt verkar miljöintresset vara ett drivande motiv till varför elcykel införskaffades. Minskad restid verkar ha en viss betydelse speciellt för den yngre åldersgruppen. Majoriteten av de svarande instämmer i påståendet att el

Chondroadherin, a leucine rich repeat extracellular matrix protein with functions in cell to matrix interactions, binds cells via their α2β1 integrin as well as via cell surface proteoglycans, providing for different sets of signals to the cell. Additionally, the protein acts as an anchor to the matrix by binding tightly to collagens type I and II as well as type VI. We generated mice with inactiv

An observational study, focusing on motorcyclists, was conducted between June and August 2012 at access points on straight road sections of primary roads in Malaysia. This was done in order to gain more insight into the actual road traffic situation at these sites. The majority of the motorcyclists kept to the speed limit and lowered speed when approaching an access point, especially when road use

Background: The ICF core sets for patients with Rheumatoid Arthritis ( RA) acknowledge sexual function and intimate relationships as important since the patients' sexual health can be affected by the disease. About 36-70% of all RA-patients experience a reduced sexual health, and their perceived problems are directly or indirectly caused by their disease. Physiotherapy is often used as non-pharmac

Objective: Negative pressure wound therapy is the first-line treatment modality for poststernotomy mediastinitis in many heart centers. The aim of this study was to analyze major complications and possible preventive methods during negative pressure wound therapy in patients with deep sternal wound infections. Methods: We retrospectively analyzed 69 consecutive patients treated with negative press

Recension av två verk om filmproducenten och regissören Roger Corman.

Spontaneous dissociative alterations in awareness and perception among highly suggestible individuals following a hypnotic induction may result from disruptions in the functional coordination of the frontal-parietal network. We recorded EEG and self-reported state dissociation in control and hypnosis conditions in two sessions with low and highly suggestible participants. Highly suggestible partic

Understanding the mechanical properties of human femora is of great importance for the development of a reliable fracture criterion aimed at assessing fracture risk. Earlier ex vivo studies have been conducted by measuring strains on a limited set of locations using strain gauges. Digital Image Correlation (DIC) could instead be used to reconstruct the full-field strain pattern over the surface of

A highly sensitive flow injection analysis (FIA)-based thermal enzyme-linked immunoassay, TELISA, was developed for the rapid detection of atrazine (ATZ) in tap water. ATZ and beta-lactamase-labeled ATZ were employed in a competitive immunoassay using a monoclonal antibody (mAb). After the off-column liquid-phase competition, the mAb was captured on the Protein G Sepharose (TM) 4 Fast Flow (PGSFF)

Popular Abstract in Swedish Diabetes relaterade fotsår är en vanlig och allvarlig komplikation till diabetes. Orsaken till fotsår är mångfasetterad och inkluderar bland annat diabetesrelaterade nervskador och försämrad funktion i stora och små blodkärl. Vid förekomst av högt blodsocker fungerar immunförsvaret sämre och problematiska infektioner är vanligare vid diabetes. Sårläkning försämras vid lChronic diabetic foot ulcers are a source of major concern for both patients and health care systems. Oxygen deficiency plays a major role in the pathogenesis of these ulcers. Hyperbaric oxygen therapy (HBOT) has been proposed as a medical treatment for diabetic foot ulcers, but the clinical utility has not been established. Hyperbaric Oxygen in Diabetic patients with chronic Foot Ulcer (HODFU) st

This essay discusses the author Sara Stridsberg's revisiting of Valerie Solana's work and anger as a feminist response to the injustice of sexism and homophobia and to envision a future loaded with feminist energy.

Popular Abstract in Swedish Cancer behandlas i första hand med kirurgi, cellgifter och extern strålbehandling. Under senare år har man dessutom utvecklat så kallade målsökande behandlingar, som binder till en viss struktur i tumören. De kan verka på olika sätt: antingen genom att blockera en signal i cellerna och på så vis hindra tumören från att växa, eller genom att stimulera patientens immunförIn radioimmunotherapy, monoclonal antibodies (mAbs) are used as a targeting agent carrying a toxic payload consisting of radionuclides. This treatment allows the irradiation of small lesions, even on the microscopic level. In the present work, two radionuclides with different properties were used. Lutetium-177 (177Lu) is a beta-particle-emitting radionuclide (t½=6.7 days) and astatine-211 (211At)

Calculations of large-scale displacement distances were made to evaluate the combined effect of small-scale movement pattern of a Collembola, Protaphorura armata. The effect of presence of food and conspecific density on turning angle, step length and activity/motility was investigated. Calculations of net square displacement were made both by assuming correlated random walk (CRW) and by resamplin

Westphal's thesis contains a summary of earlier structural analyses of Hebrews. Her own discourse analysis structures Hebrews into three parts 1) 1:1–4:16; 2) 4:11–7:28 and 8:1–10:25; 3) 10:19–13:25. Westphal characterizes Heb 4:11-16 and 10:19-25 as "overlapping" parts and as keys to the structure and meaning of Hebrews. The structure according to this approach is not new. A shortcoming in this t