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CTLA-4 blockade boosts the expansion of tumor-reactive CD8+ tumor-infiltrating lymphocytes in ovarian cancer

Adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs) can induce durable complete tumor regression in patients with advanced melanoma. Efforts are currently underway to expand this treatment modality to other cancer types. In the microenvironment of ovarian cancer, the engagement of co-inhibitory immune checkpoint molecules such as CTLA-4 can lead to the inactivation of

Comparison of outcomes of four different treatment modalities for diabetic vitreous haemorrhage

We compared outcomes of four different management modalities for diabetic VH. Patients with diabetic VH were identified in this retrospective study undertaken at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Eyes were grouped based on the treatment received: control (observation only), intravitreal bevacizumab (IVB) injection(s), pars plana vitrectomy (PPV), and preoperative single IV

Hyperparameter Optimization for Portfolio Selection

Portfolio optimization involves a tradeoff between maximizing expected returnand minimizing risk. In practice, useful formulations also include various costs and constraints that regularize the problem and reduce the risk due to estimation errors, resulting in solutions that depend on a number of hyperparameters. As the number of hyperparameters grows, selecting their value becomes increasingly imPortfolio selection involves a trade-off between maximizing expected return and minimizing risk. In practice, useful formulations also include various costs and constraints that regularize the problem and reduce the risk due to estimation errors, resulting in solutions that depend on a number of hyperparameters. As the number of hyperparameters grows, selecting their value becomes increasingly imp

Profiling the Protein Targets of Unmodified Bio-Active Molecules with Drug Affinity Responsive Target Stability and Liquid Chromatography/Tandem Mass Spectrometry

Identifying the target proteins of bioactive small molecules is a key step in understanding mode-of-action of the drug and addressing the underlying mechanisms responsible for a particular phenotype. Proteomics has been successfully used to elucidate the target protein profiles of unmodified and ligand-modified bioactive small molecules. In the latter approach, compounds can be modified via click

Radiographers' Experience of Work Performance After Attending a Postgraduate Course in Appendicular Reporting—A Qualitative Study

The radiography profession in Sweden is young but has been rapidly changing over the recent years. The developing profession has led to radiographers facing various challenges related to responsibility for both the technical equipment and patient care in the periradiographic process. Further education is urgent to keep up with the arising level of competence required. The study aimed to explore ra

Comparison of three methods to determine the degree of substitution of quinoa and rice starch acetates, propionates, and butyrates : Direct stoichiometry, FTIR, and 1H-NMR

Rice and quinoa starch esters were prepared by acylation using short-chain fatty acid anhydrides with different chain lengths (acetic, propionic, and butyric anhydride). A direct stoichiometric method based on the acylation reaction was used to determine the degree of substitution (DS) and acyl content (AC). In addition, Fourier-transform infrared spectroscopy (FTIR) was used to validate the confo

Selective pressurized hot water extraction of nutritious macro-nutrients vs. micro-nutrients in Moringa oleifera leaves—a chemometric approach

Moringa oleifera leaves are widely used in traditional medicine as a food supplement because they are high in essential and nutritious content. Pressurized hot water extraction (PHWE), which is a green approach, was used for the recovery of the macro-nutrient and micro-nutrient elements from dried leaf powder of Moringa oleifera. In this study, response surface methodology was applied to assess th

Facilitating Versus Inhibiting the Transmission of Drug Abuse from High-Risk Parents to Their Children : A Swedish National Study

We seek to identify factors that facilitate or inhibit transmission of drug abuse (DA) from high-risk parents to their children. In 44,250 offspring of these parents, ascertained from a Swedish national sample for having a mother and/or father with DA, we explored, using Cox models, how the prevalence of DA was predicted by potentially malleable risk factors in these high-risk parents, their spous

Occupational balance and its association with life satisfaction in men and women with rheumatoid arthritis

Introduction: Despite improved treatments and reduced disability, people with rheumatoid arthritis (RA) experience difficulties in daily life, which may negatively affect their balance of everyday life activities (occupational balance). The aim of this study was to describe occupational balance and its association with self-rated life satisfaction in men and women with RA. Methods: A survey, inclu