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Objective: To assess comparative effectiveness, safety, and tolerability of off-label rituximab, compared with frequently used therapies approved for multiple sclerosis (MS). Methods: A Swedish cohort study of persons with relapsing–remitting MS, age 18 to 75 years at inclusion and with a first therapy start or a first therapy switch between 2011 and 2018. Low-dose rituximab was compared with MS-a

When people talk about kinship systems, they often use co-speech gestures and other representations to elaborate. This paper investigates such polysemiotic (spoken, gestured, and drawn) descriptions of kinship relations, to see if they display recurring patterns of conventionalization that capture specific social structures. We present an exploratory hypothesis-generating study of descriptions pro

Identification and characterization of CD8+ T-cells is important to determine their role in protecting and clearing viral infections. Here we provide details of the peptide-MHC (pMHC) tetramers-based approach to identify antigen-specific T-cells in human and murine samples. This method provides ex vivo quantifica-tion and functional characterization of T-cells reactive to specific viral antigens d

The operational map of the H3 Mach 6 blowdown wind tunnel, at the von Karman Institute for Fluid Dynamics (VKI), is extended towards lower Mach numbers with a new axisymmetric contoured nozzle to achieve Mach 5 testing conditions. Following the design, manufacturing, instrumentation and integration of the Mach 5 nozzle, an extensive commissioning campaign is initiated. The flow investigations rely

Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes1. Yet both activation and inhibition of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in combination with glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) activation have resulted in similar clinical outcomes, as demonstrated by the GIPR–GLP-1R co-agonist tirzepatide2 and AMG-133 (ref

This chapter foregrounds the fictional and factual relations that inform contemporary human-animal entanglements in manga and anime through the series One Piece. The epic journey of the ‘Straw Hat Crew’ in search for freedom and empowerment is characterised by its multispecies cast, subversive themes, and social commentary. However, by examining its depictions of gender and multispecies relations

Water resources are fundamental to life, ecosystems, and human development. In an era of climate change and increasing water scarcity, effective management of these resources is crucial, particularly in cold regions where glaciers and snow play vital roles in hydrological cycles. Understanding and accurately modelling these complex systems is essential for sustainable water resource management, cl

Non-volatile cryogenic memories are crucial for realizing energy-efficient and scaled quantum computing systems. In this letter, we evaluate the cryogenic performance of an HZO-based ferroelectric capacitor (FeCAP) with a compound semiconductor (InAs) as the bottom electrode. We demonstrate that near identical remnant polarization can be obtained at 14 K compared to room temperature by increasing

We propose a novel non-negative spherical relaxation for optimization problems over binary matrices with injectivity constraints, which in particular has applications in multi-matching and clustering. We relax respective binary matrix constraints to the (high-dimensional) non-negative sphere. To optimize our relaxed problem, we use a conditional power iteration method to iteratively improve the ob

Cooperative driving is a promising paradigm to improve traffic efficiency and safety. In congested traffic scenarios, such cooperation allows for safe maneuvering and driving with small inter-vehicle spatial gaps. The vehicles involved coordinate their movements in real-time and continuously update each other about their maneuver execution status by means of Vehicle-to-Everything (V2X) communicati