Sökresultat

Filtyp

Din sökning på "*" gav 529852 sökträffar

An evaluation of the influence of devazepide and CCK-8S on the intact and resected rat liver

BACKGROUND: Recently, it has been shown that infusion of the CCK-A receptor antagonist devazepide induced proliferation of hepatocytes and bile duct epithelium in the rat liver. The aim of this study was to further evaluate the influence of devazepide and sulfated cholecystokinin-8 (CCK-8S) on the intact rat liver and rat liver after resection. METHODS: In the first experiment, either saline or de

Immune tolerance induction: recombinant vs. human-derived product

The ultimate goal in the treatment of high-responding inhibitors in congenital haemophilia is to induce immune tolerance (IT). Since the advent of highly purified factor VIII products, especially recombinant ones, the issue has been raised of whether the type of product has an impact on treatment success. It is clear that IT induction is possible to achieve with both recombinant products and human

C4b-binding protein (C4BP) activates B cells through the CD40 receptor

We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with

Response of a Sedum green-roof to individual rain events

Precipitation and runoff data from several controlled experiments (with dry and wet initial conditions) on a Sedum album green-roof have been analysed by means of linear programming in order to estimate a unit hydrograph (UH). The obtained UH was able to accurately predict peak flows and runoff volumes for any rain input. Results from the experiments indicated that roof slope had no effect on the

Theory in social work—some reflections on understanding and explaining interventions [Teori i socialt arbete—några reflektioner om att förstå och förklara interventioner]

This article reflects on theory in social work. With a starting point in the contemporary discussion of evidence-based social work, we raise questions about the role of theory. To understand empirical data, we need theory. The arena of social work is an open field for many academic disciplines, and theories used for understanding social work are mostly imported from general social science. Theory

Incidence of myocardial infarction in women. A cohort study of risk factors and modifiers of effect

STUDY OBJECTIVE: To assess whether the increased incidence of myocardial infarction and death associated with smoking, hypertension, hyperlipidaemia and diabetes varies significantly between groups defined in terms of occupation, education and marital status. SETTING: Malmo, Sweden. PARTICIPANTS: 9351 women, aged 28-55, with a mean follow up of 10.7 years. MAIN RESULTS: Smoking, hypertension (> or

Elliptic flow of identified hadrons in Au+Au collisions at root s(NN)=200 GeV

The anisotropy parameter (v(2)), the second harmonic of the azimuthal particle distribution, has been measured with the PHENIX detector in Au+Au collisions at roots(NN)=200 GeV for identified and inclusive charged particle production at central rapidities (eta2 GeV/c, in marked contrast to the predictions of a hydrodynamical model. A quark-coalescence model is also investigated.

Twelve-lead electrocardiogram: The advantages of an orderly frontal lead display including lead -aVR

Background: It is possible that efforts in ECG review by both young experienced clinicians are currently discouraged-and risk to be completely dismissed-by the conventional (ie, disorderly) display of the frontal plane leads, with lead aVR at -150degrees. Methods: We reviewed studies on the usefulness of leads aVR and -aVR as well as on the history of the frontal leads in electrocardiography. Resu

Good visions, bad micro-management and ugly ambiguity: Contradictions of (non-)leadership in a knowledge-intensive organization

This article investigates how managers position themselves and their work in terms of leadership in a large knowledge-intensive company. The significance of contemporary discourse on leadership, practical aspects of managerial work, and ambiguity as a central dimension of organization and leadership (particularly in knowledge-intensive settings) are highlighted. We examine the presumed leadership

Fatigue in patients with chronic heart failure - A burden associated with emotional and symptom distress

Background: The relationship between experience of fatigue and emotional and symptom distress in chronic heart failure (CHF) needs to be thoroughly explored, because fatigue has major impact on daily activities in life. Aims: The purpose was to examine the association between fatigue, as a multidimensional experience and anxiety, depression and symptom distress, and to explore the relationships be

A comparative study of forward error correction and frame accumulation for VoIP over congested networks

We compare Forward Error Correction (FEC) and frame AC-Cumulation (ACC) to see which of the two schemes most effectively reduce frame loss rate for an aggregate of VoIP flows, sharing a network bottleneck. We model this bottleneck by a M/M/1/K queue and we analytically show that given certain assumptions, FEC is the best choice for low initial load at the bottleneck. Then, as the initial load incr

Developing a classifier for the habitats directive grassland types in Denmark using species lists for prediction

This paper describes the use of supervised methods for the classification of vegetation. The difference between supervised classification and clustering is outlined, with reference to their current use in vegetation science. In the paper we describe the classification of Danish grasslands according to the Habitats Directive of the European Union, and demonstrate how a supervised classification can

JAM-A expression positively correlates with poor prognosis in breast cancer patients

The cell-cell adhesion protein junctional adhesion molecule-A (JAM-A) influences; epithelial cell morphology and migration. As migration is required for tumor cell invasion and metastasis, we sought to elucidate the role of JAM-A in invasive breast cancer. A breast cancer tissue microarray was analyzed for JAM-A protein expression, in parallel with analysis of JAM-A gene expression data from a bre

Fluorometric broad-range screening of compounds with affinity for nucleic acids

The potential of a nucleic acid-based optical bioprobe for environmental measurements and drug monitoring is described. The sensor employs the long-wavelength intercalating fluorophore TO-PRO-3 (TP3). Compounds that interact with the TP3-DNA complex are indirectly detected by a decrease in the fluorescence intensity. We found that the configuration and length of the DNA dramatically affected the i

Animal models of endocrine/organ-specific autoimmune diseases: do they really help us to understand human autoimmunity?

Organ-specific or endocrine autoimmune diseases are complex, polygenic afflictions the penetrance of which is heavily dependent on various environmental influences. Important target tissues are the thyroid, the islets of Langerhans, gastric parietal cells and steroid-producing cells in the adrenal and ovary. The etiology of these diseases remains to be clarified. The pathogenesis is strongly assoc

Decomplexing biofluids using microchip based acoustophoresis

Highly efficient washing and extraction of microbeads to decomplex analytes ranging from small peptides to large viruses was realised in a microscaled continuous flow format. The bead washing principle reported herein is based on acoustophoresis, i.e. the primary acoustic radiation force in an ultrasonic standing wave and laminar flow properties are utilised to translate bioanalytes trapped on fun

Amorphous drug nanosuspensions. 2. Experimental determination of bulk monomer concentrations

A simple turbidimetric method was developed to measure the bulk concentration of drug in nanosuspensions. The bulk concentrations measured were in the range from 1 mu M to 1 mM. The accuracy of the method was checked by determination of the bulk concentration of crystalline nanosuspensions, i.e., the crystalline solubility, which compared favorably to solubilities measured by a conventional method