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Associations of CSF PDGFRβ With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes
BACKGROUND AND OBJECTIVES: Injured pericytes in the neurovascular unit release platelet-derived growth factor β (PDGFRβ) into the cerebrospinal fluid (CSF). However, it is not clear how pericyte injury contributes to Alzheimer's disease (AD)-related changes and blood brain barrier (BBB) damage. We aimed to test if CSF PDGFRβ was associated with different AD- and age-associated pathological changes
High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022
We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall viral seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvaccinated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more pathogenic variants.
Neuroanatomic Signatures in Brachioradial Pruritus, Chronic Prurigo, and Atopic Dermatitis
Ivacaftor therapy post myocardial infarction augments systemic inflammation and evokes contrasting effects with respect to tissue inflammation in brain and lung
Acquired cystic fibrosis transmembrane regulator (CFTR) dysfunctions have been associated with several conditions, including myocardial infarction (MI). Here, CFTR is downregulated in brain, heart, and lung tissue and associates with inflammation and degenerative processes. Therapeutically increasing CFTR expression attenuates these effects. Whether potentiating CFTR function yields similar benefi
Inget zoo kan rädda kröningsceremonin
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Detta är en bearbetad version på nederländska av min tidigare på svenska utgivna biografi om den engelske kungen Henrik VIII.De Zweedse hoogleraar Dick Harrison vertelt het kleurrijke levensverhaal van Hendrik VIII (1491-1547). Hendrik werd, na de dood van zijn vader, de tweede Tudor-koning van Engeland. Hij leidde een roemrucht bestaan. Hij had zes echtgenotes, van wie hij er twee liet onthoofden. Hij scheidde, voor eigen gewin, de Anglicaanse kerk af van de Kerk van Rome, en hij verenigde Engeland en Wales wettelijk i
Consistency of LPJ GUESS projections of managed forest structure with observations across a latitudinal gradient
Continuous evaluation of model results against observational data isvital to improving model projections of the structure and function offorest ecosystems. In this poster, we evaluate the forest management module of LPJ-GUESS (ver. 4. 1.2, rev 11016) across a latitudinal gradient in Sweden. The poster was presented at the LPJ-GUESS Community Meeting in Lund, May 3rd, 2023.
Well-being Processes : Insights into Personal Growth and Adolescent Mental Health
Denna avhandling belyser välbefinnandeprocesser utifrån två olika angreppssätt: 1)dels teoretiska beskrivningar av personligt växande, där personligt växandedefinieras som den gradvisa processen av förändring i välbefinnande, 2) delsempiriska undersökningar av välbefinnande och mental hälsa med fokus på eleversmentala hälsoprofiler och självuppfattning. Sammanlagt ingår fem studier iavhandlingen, This thesis follows two main lines of inquiry into well-being processes: 1) atheoretical exploration of personal growth, defined as the gradual growth of wellbeing, and 2) an empirical exploration of students’ mental health profiles and sense of self. Altogether five studies are included in the thesis, two of which follow thefirst line of inquiry (articles I and II) and three of which follow the s
Towards optimization of anomaly detection in DevOps
Context: DevOps has recently become a mainstream solution for bridging the gaps between development (Dev) and operations (Ops) enabling cross-functional collaboration. The DevOps concept of continuous monitoring may bring a lot of benefits to development teams such as early detection of run-time errors and various performance anomalies. Objective: We aim to explore deep learning (DL) solutions for
Hypothermic versus Normothermic Temperature Control after Cardiac Arrest
BACKGROUNDThe evidence for temperature control for comatose survivors of cardiac arrest is inconclusive. Controversy exists as to whether the effects of hypothermia differ per the circumstances of the cardiac arrest or patient characteristics.METHODSAn individual patient data meta-analysis of the Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest (TTM) and Hypothermia versus
Rethinking the Haitian Turn : Beyond the Universality Paradigm and Its Enemies
Recent assessments of the literature on the Haitian Revolution (1791–1804) offer radically different images, ranging from the identification of a politics of universal human rights to objections against conservative assumptions. The present article instead uncovers an overarching conflict between what is named the universality paradigm and the sceptical responses. However, in the outskirts of the
The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data
Open science and collaboration are necessary to facilitate the advancement of Parkinson’s disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, duri
Ex vivo and in vivo experimental investigation of miR-148a-3p as a novel therapy for insulin secretion and type 2 diabetes
Impact analysis of energy efficiency measures in the electrolysis process in primary aluminium production
The Paris Agreement includes the goals of ‘holding the increase in the global average temperature to well below 2°C above pre-industriallevels’ and ‘making finance flows consistent with a pathway towards low greenhouse gas emissions’. Industrial energy efficiency will playan important role in meeting those goals as well as becoming a competitive advantage due to reduced costs for companies. The al
Liposuction for Advanced Lymphedema in a Multidisciplinary Team Setting in Australia - Five-Year Follow-Up
Background: Liposuction for International Society of Lymphology (ISL) late stage II or III limb lymphedema is an established surgical option to remove excessive adipose tissue deposition and has been performed in Australia since 2012 at the Australian Lymphoedema Education, Research and Treatment (ALERT) Program, Macquarie University.Patients and methods: Between May 2012 and May 2017, 72 patientsBackground: Liposuction for International Society of Lymphology (ISL) late stage II or III limb lymphedema is an established surgical option to remove excessive adipose tissue deposition and has been performed in Australia since 2012 at the Australian Lymphoedema Education, Research and Treatment (ALERT) Program, Macquarie University.Patients and methods: Between May 2012 and May 2017, 72 patients
Spherical White with Diamond
Site-specific public work, commissioned by NATUR North Atlantic Tales/Curated Place in collaboration with National Trust Formby. The work includes three sound installations: 'Spherical White with Diamond', stereo work (voice: Jez Dolan). 'Þytur', 9 mono-channels (voices: Maja Jantar, Angela Rawlings, Halla Steinunn Stefánsdóttir). 'The Shadowy Space Beneath', a stereo work, which builds on texts f
Spherical White with Diamond
A stereo work, part of the site-specific public work, 'Spherical White with Diamond' commissioned by NATUR North Atlantic Tales/Curated Place in collaboration with National Trust Formby. Voice: Jez Dolan.
Þytur
A nine mono-channel installation, part of the site-specific public work 'Spherical White with Diamond' commissioned by NATUR North Atlantic Tales/Curated Place in collaboration with National Trust Formby. Voices: Maja Jantar, Angela Rawlings, Halla Steinunn Stefánsdóttir.
The Shadowy Space beneath
Stereo work, part of the site-specific public work, 'Spherical White with Diamond', commissioned by NATUR North Atlantic Tales/Curated Place in collaboration with National Trust Formby. The work builds on text from Jane Sprackland’s 'Strands' (2013). Voices: David Dolan Martin, Ellie Paskall and Alicia Prowse.