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The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site

Background: The involvement of aquaporin (AQP) water and small solute channels in the etiology of several diseases, including cancer, neuromyelitis optica and body fluid imbalance disorders, has been suggested previously. Furthermore, results obtained in a mouse model suggested that AQP9 function contributes to hyperglycemia in type-2 diabetes. In addition, the physiological role of several AQP fa

Protein C Inhibitor

Protein C inhibitor (PCI) is a serine protease inhibitor and was originally identified as an inhibitor of activated protein C (APC). However, PCI is not specific for APC and also inhibits several proteases involved in coagulation, fibrinolysis, cancer, wound healing, and fertility. The biological function of PCI is unknown due to broad enzyme specificity, its wide tissue distribution, and the lack

Heavy-flavor electron-muon correlations in p plus p and d plus Au collisions at root s(NN)=200 GeV

Background: Heavy-flavor modification in relativistic p(d) + A collisions are sensitive to different kinds of strong-interaction physics ranging from modifications of the nuclear wave function to initial- and final-state energy loss. Modifications to single heavy-flavor particles and their decay leptons at midrapidity and forward rapidity are well established at the Relativistic Heavy Ion Collider

European Association of Urology Guidelines on Male Infertility: The 2012 Update

Context: New data regarding the diagnosis and treatment of male infertility have emerged and led to an update of the European Association of Urology (EAU) guidelines for Male Infertility. Objective: To review the new EAU guidelines for Male Infertility. Evidence acquisition: A comprehensive work-up of the literature obtained from Medline, the Cochrane Central Register of Systematic Reviews, and re

Optimizing Positively Dominated Systems

It has recently been shown that several classical open problems in linear system theory, such as optimization of decentralized output feedback controllers, can be readily solved for positive systems using linear programming. In particular, optimal solutions can be verified for large-scale systems using computations that scale linearly with the number of interconnections. Hence two fundamental adva

TEM determination of directions of (Ga,Mn)As nanowires grown by MBE on GaAs(001) substrates

P>The structure of GaMnAs nanowires (NW) with nominal Mn concentration of up to 7 at% was investigated by transmission electron microscopy. The (Ga,Mn)As NW were grown on epiready GaAs(001) n-type wafers by molecular beam epitaxy. The crystal structure of the NW was determined to be zinc-blende. NW with Mn concentrations lower than 5 at% grow along the > direction. NW with higher Mn concentrations

A prospective study of Helicobacter pylori in relation to the risk for pancreatic cancer

Background: The relationship between Helicobacter pylori infection and pancreatic cancer has been investigated in three previous studies with contradictory results. The aim of the present study was to investigate the association between H. pylori seropositivity and the risk for pancreatic cancer in a nested case-control study within a population based cohort. Methods: Selected birth- year cohorts

Measurements of CP-conserving trilinear gauge boson couplings WWV (V gamma, Z) in e(+)e(-) collisions at LEP2

The data taken by DELPHI at centre-of-mass energies between 189 and 209 GeV are used to place limits on the CP-conserving trilinear gauge boson couplings Delta g(1)(Z), lambda(gamma) and Delta k(gamma) associated to W+W- and single W production at LEP2. Using data from the jjl nu, jjjj, jjX and lX final states, where j,l and X represent a jet, a lepton and missing four-momentum, respectively, the

Self-Probing Spectroscopy of the SF6 Molecule: A Study of the Spectral Amplitude and Phase of the High Harmonic Emission

We present characterizations of the attosecond pulse train produced in the high harmonic generation (HHG) from SF6 molecules irradiated by a strong pulsed laser field at 800 nm. At harmonic order 17, we observe a minimum in the amplitude of the emitted spectrum and a corresponding distortion in the phase. Our experimental results are compared to two models: a multicenter interference model focused

Soil water and salinity distribution under different treatments of drip irrigation.

In this study, field experiments and numerical simulations for different drip irrigation treatments in a sandy loam soil were conducted to investigate soil water and salinity distribution as well as dye infiltration patterns. Three treatments, surface drip irrigation without and with plastic mulch (T1 and T2, respectively); and subsurface drip irrigation (T3), were used. In addition, daily and bi-

Prostate cancer diagnosed after prostate-specific antigen testing of men without clinical signs of the disease: A population-based study from the National Prostate Cancer Register of Sweden

Objective. To investigate the effects of prostate-specific antigen (PSA) testing of men without clinical signs of prostate cancer on the incidence of prostate cancer in Sweden. Material and methods. Information on the cause of diagnosis, tumour characteristics and primary treatment for patients diagnosed with prostate cancer between January 1999 and December 2007 was extracted from the National Pr

Acute Health Effects on Planters of Conifer Seedlings Treated with Insecticides

Objectives: The aim of this study was to assess acute health effects on planters caused by planting conifer seedlings treated with two insecticides, with active ingredients imidacloprid and cypermethrin, in comparison with untreated seedlings. Methods: The investigation was a double-blind crossover study, which included a follow-up of 19 planters over a 3-week period. During Week 1, the 19 planter

Empirical Equations for Intrinsic and Effective Evaporative Resistances of Multi-layer Clothing Ensembles

To determine the intrinsic and effective clothing evaporative resistances,both in the individual clothing, and in the nulti-layer clothing ensembles meant for winter season, a fabric sweating thermal manikin Walter was used. Based on the tests performed on the individual garments, two empirical equations were developed for the estimation of these resistances, useful either to clothing manufacturer

Nuclear Genomic Sequences Reveal that Polar Bears Are an Old and Distinct Bear Lineage

Recent studies have shown that the polar bear matriline (mitochondrial DNA) evolved from a brown bear lineage since the late Pleistocene, potentially indicating rapid speciation and adaption to arctic conditions. Here, we present a high-resolution data set from multiple independent loci across the nuclear genomes of a broad sample of polar, brown, and black bears. Bayesian coalescent analyses plac