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Launching the Mission for 100 Climate Neutral Cities in Europe: Characteristics, Critiques, and Challenges

The purpose of this perspective article is to critically explore the launch of the mission for 100 climate neutral cities in Europe. An overview of the mission approach in general is first presented, where key aspects and emerging critiques are identified. Second, key elements of the mission for 100 climate neutral cities in Europe are introduced along with some of its challenges and ambiguities.

Soluble CD40 levels in plasma are associated with cardiovascular disease and in carotid plaques with a vulnerable phenotype

Background and Purpose CD40 and CD40 ligand (CD40L) are costimulatory molecules of the tumor necrosis factor receptor superfamily and well known for their involvement in inflammatory diseases: atherosclerotic mouse models with disrupted CD40 signalling develop lesions of reduced size with a more stable plaque profile. This study investigated the potential of plasma and intraplaque levels of CD40 a

Form follows function in human nonverbal vocalisations

Until recently, human nonverbal vocalisations such as cries, laughs, screams, moans, and groans have received relatively little attention in the human behavioural sciences. Yet these vocal signals are ubiquitous in human social interactions across diverse cultures and may represent a missing link between relatively fixed nonhuman animal vocalisations and highly flexible human speech. Here, we revi

Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand

Monoclonal antibodies (mAb) are used as therapeutics and for diagnostics of a variety of diseases, and novel antibodies are continuously being developed to find treatments for new diseases. Therefore, the manufacturing process must accommodate a range of mAb characteristics. Acid-sensitive mAbs can severely compromise product purity and yield in the purification process due to the potential format

Improving reach of health promotion during implementation in a Swedish municipality setting

Introduction: To reach the intended target group is crucial if the health effects potentially following health promoting interventions for seniors shall be realized. The aim of this study was to improve reach of health promotion during implementation in a Swedish municipality context.Material & Methods: A mixed-methods approach was applied during four phases in which recruitment and interventi

Ageing in the right place – the development of a web-based housing counselling intervention

Introduction: Despite a strong wish of most seniors to age in place, no services exist to support seniors in their residential reasoning, i.e., to plan and prepare for future housing needs. The aim of this study was to describe the first steps of development of a web-based housing counseling intervention aiming to promote active ageing.Material & Methods: A user-centered design process was app

Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

The production of biopharmaceuticals so far has been based on batch processes that are robust and well-known, but very inefficient and inflexible, causing the products to be very expensive and process development to be slow and costly. The production of biopharmaceuticals is thus changing towards integrated continuous biomanufacturing (ICB) in order to reduce costs and increase flexibility in a co

MicroRNA‐100 Reduced Fetal Bovine Muscle Satellite Cell Myogenesis and Augmented Intramuscular Lipid Deposition by Modulating IGF1R

Previously, microRNA‐100 (miR‐100) and its putative mRNA target, insulin‐like growth factor receptor‐1 (IGF1R) were identified as differentially and inversely expressed in bovine longissimus dorsi (LD) muscles with divergent intramuscular fat (IMF) content by our group. While IGF1R signaling is implicated in myogenesis and muscle lipid metabolism, the underlying regulatory mechanisms are poorly un

Corona-pandemins kaskadeffekter på lokal och regional nivå med avseende på samhällsviktiga funktioner : Mot ökad motståndskraft

Rapporten fokuserar på hur Covid-19 har påverkat olika samhällsviktiga verksamheter i Skåne. Verksamheterna har påverkats mycket, men det har inte uppstått allvarliga funktionsstörningar. Undantagen är Hälso- och sjukvård samt omsorg, och Transportsektorn där även funktionspåverkan förekommit I rapporten analyseras även hur förberedelser har skett och vilka lärdomar som kan dras av Covid-19.

Nonresonant two-level transitions: Insights from quantum thermodynamics

Based on concepts from quantum thermodynamics, the two-level system coupled to a single electromagneticmode is analyzed. Focusing on the case of detuning, where the mode frequency does not match the transitionfrequency, effective energies are derived for the levels and the photon energy. It is shown that these should be usedfor energy exchange with fermionic and bosonic reservoirs in the steady st

Domain-adversarial neural network for improved generalization performance of gleason grade classification

When training a deep learning model, the dataset used is of great importance to make sure that the model learns relevant features of the data and that it will be able to generalize to new data. However, it is typically difficult to produce a dataset without some bias toward any specific feature. Deep learning models used in histopathology have a tendency to overfit to the stain appearance of the t

Determinants of continued maternal care seeking during pregnancy, birth and postnatal and associated neonatal survival outcomes in Kenya and Uganda : analysis of cross-sectional, demographic and health surveys data

OBJECTIVES: To examine how maternal and sociodemographic factors determine continued care-seeking behaviour from pregnancy to postnatal period in Kenya and Uganda and to determine associated neonatal survival outcomes.DESIGN: A population-based analysis of cross-sectional data using multinomial and binary logistic regressions.SETTING: Countrywide, Kenya and Uganda.PARTICIPANTS: Most recent live bi

Explosive remnants in Swedish society : Standardization to visualize a complex risk picture

Explosive remnants from military activities imply a complex and costly risk to be dealt with in society. The problem involves different risks that are currently managed in isolation and by different stakeholders. For prioritization and ranking between all contaminated areas, a common risk picture needs to be presented and communicated to decision-makers. This chapter analyses the pros and cons of

Three-dimensional fluid-structure interaction numerical simulation of new type vortex generators in smooth wavy fin-and-elliptical tube heat exchanger

A three-dimensional numerical fluid-structure interaction (FSI) framework is successfully carried out on mechanical behaviour of new vortex generators (VGs) – rectangular trapezoidal winglet (RTW), angle rectangular winglet (ARW), curved angle rectangular winglet (CARW) – in smooth wavy fin-and-elliptical tube (SWFET) heat exchanger using the ANSYS MFX Multi-field® solver. The purpose of the prese

Numerical investigation on convective heat transfer of aviation kerosene in a vertical mini-tube at supercritical pressures

Convective heat transfer of aviation kerosene at supercritical pressures in a vertical upward tube of diameter 1.8 mm was numerically studied using RNG k-ε turbulence model with enhanced wall treatment. The thermo-physical and transport properties of the China RP-3 kerosene at various temperatures were obtained by a 10-species surrogate and the NIST Supertrapp software. The grid independence was f