BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context.METHODS: We u

BACKGROUND: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195

BACKGROUND: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors

Coexistence between humans and wildlife faces challenges for wildlife as well as human wellbeing and livelihoods. Learning, development, and transformative change in the adaptive use of management interventions across cultures and species are highly needed. This calls for thorough evaluation of interventions on both ecological and human dimensions parameters. Existing evaluations of management int

Streptococcus suis is an important meningitis-causing pathogen in pigs and humans. Neutrophil extracellular traps (NETs) have been identified as host defense mechanism against different pathogens. Here, NETs were detected in the cerebrospinal fluid (CSF) of S. suis-infected piglets despite the presence of active nucleases. To study NET-formation and NET-degradation after transmigration of S. suis

NETs (neutrophil extracellular traps) have been described as a fundamental innate immune defence mechanism. During formation of NETs, the nuclear membrane is disrupted by an as-yet unknown mechanism. In the present study we investigated the role of human cathelicidin LL-37 in nuclear membrane disruption and formation of NETs. Immunofluorescence microscopy revealed that 5 μM LL-37 significantly fac

BACKGROUND: Aquaporins (AQPs) are integral membrane proteins that facilitate transport of water and/or other small neutral solutes across membranes in all forms of life. The X Intrinsic Proteins (XIPs) are the most recently recognized and the least characterized aquaporin subfamily in higher plants. XIP1s have been shown to be impermeable to water but permeable to boric acid, glycerol, hydrogen pe

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Water drainage from porous media is a highly dynamic process often marked by rapid piston-like air invasion events at the front and other rapid interfacial reconfigurations. Liquid phase entrapped behind the moving front drains at significantly slower rates often via gravity driven flow through corners and crevices. This distribution of slowly draining residual water phase determines the plant ava

This research uses data from observations of 8277 motorcyclists at various types of roads of the road hierarchy in Malaysia in 2015, to investigate the effects of road characteristics, motorcyclists’ riding behaviour, motorcyclists’ and motorcycles’ characteristics on the occurrence of riding with excessive speed. For data collection and analysis, new software, i.e. MECHROM, was developed. The speThis research uses data from observations of 8277 motorcyclists at various types of roads of the road hierarchy in Malaysia in 2015, to investigate the effects of road characteristics, motorcyclists’ riding behaviour, motorcyclists’ and motorcycles’ characteristics on the occurrence of riding with excessive speed. For data collection and analysis, new software, i.e. MECHROM, was developed. The spe

Modern medicine is overwhelmed by a plethora of both established risk factors and novel biomarkers for diseases. The majority of this information is expressed by probabilistic measures of association such as the odds ratio (OR) obtained by calculating differences in average "risk" between exposed and unexposed groups. However, recent research demonstrates that even ORs of considerable magnitude ar