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(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains

Amino acid starvation is sensed by Escherichia coli RelA and Bacillus subtilis Rel through monitoring the aminoacylation status of ribosomal A-site tRNA. These enzymes are positively regulated by their product-the alarmone nucleotide (p)ppGpp-through an unknown mechanism. The (p)ppGpp-synthetic activity of Rel/RelA is controlled via auto-inhibition by the hydrolase/pseudo-hydrolase (HD/pseudo-HD)

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Ziel der Arbeit ist es, eine Analyse sozio-technischer Energieszenarien durchzuführen, um herauszufi nden, inwieweit soziologische Dimensionen beziehungsweise Konzepte in diesem enthalten sind und welche dabei am häufi gsten aufgegriff en werden. In der vorliegenden Arbeitist eine qualitati ve Inhaltsanalyse dieser Energieszenarien nach Mayring durchgeführt worden.Dabei bestand der theoreti sche H

Do you see what I mean? An Analysis of the visual representation of energy data

Our society is built upon energy – we need energy for its functioning and development.However, given our current dependence on non-renewable energy sources, a more sustainableuse needs to be achieved. A new tool of science and sustainability communication isvisualization to increase public awareness and understanding of energy issues.The aim of the study was to examine how energy data can be visua

Generating Knowledge on Networks in Environmental Governance

This paper introduces the special issue on “Generating Sustainability-Supporting Knowledge on Social Networks in the Governance and Management of Social–Ecological Systems.” Understanding the interactions of actors and institutions is important for successful governance of human–nature relations. Social network analysis is able to capture and analyze these governance and management interactions, a

Exploring perceptions of stakeholder roles in ecosystem services coproduction

Stakeholder groups engage in ecosystem services coproduction as both coproducers and beneficiaries. Stakeholder group perceptions of their own and each other’s roles in ecosystem services coproduction therefore influence how ecosystem services are provided in a given landscape. However, only a few studies have investigated self-perceived and attributed stakeholder group roles in this context. The

Psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic - A qualitative systematic review

Background: Frontline nurses have been directly exposed to the SARS-CoV-2 virus and come in close contact with patients during the COVID-19 pandemic. Nurses execute tasks related to disease control and face multiple psychosocial challenges in their frontline work, potentially affecting their mental well-being and ability to satisfyingly perform their tasks.Objectives: To explore the psychosocial e

Working with startups? these are the three things you ought to know about startup teams

While much has been written about how startups work to develop their product, this paper focuses instead on how to manage the startup team. Based on a systematic review of current research, I present actionable insights about startup team characteristics; who they are, how they work, and how they stay together. I explain how these characteristics imply both opportunities and threats for the viabil

Patch Testing with Methylchloroisothiazolinone/Methylisothiazolinone Using a New Diagnostic Mix - A Multicenter Study from the International Contact Dermatitis Research Group

Background In the early 1980s, a preservative containing a mixture of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) in a ratio of 3:1 was introduced. This mixture (mix) has been patch tested at 100 ppm (0.01%) worldwide and at 200 ppm (0.02%) in Sweden since 1986 and also in the European baseline series since 2014. Objective A new aqueous mix of MCI 0.015% and MI 0.2% was compar

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Summary . Pied Flycatchers Ficedula hypoleuca are known to be victims of nest killings in contexts of competition for nest boxes. However, there is only anecdotal information on their opposite role as perpetrators of nest takeovers and occasional killings of other songbirds. Over 31 years we examined whether competition with Great Tits Parus major over nest box ownership is a significant source of

The social worker-client relationship in the digital era: : a configurative literature review

Relationen mellan socialarbetare och klienter beskrivs som central för socialt arbete men är ett brett och mångtydigt begrepp. Idag stärks och utmanas relationen genom digitalisering. Syftet med denna konfigurativa litteraturöversikt är att förstå hur forskning om socialt arbete mellan 2015 och 2020 beskriver och analyserar digitaliseringens betydelse för relationen mellan socialarbetare och klien

The Impacts of Climate and Wildfire on Ecosystem Gross Primary Productivity in Alaska

The increase in wildfire occurrence and severity seen over the past decades in the boreal and Arctic biomes is expected to continue in the future in response to rapid climate change in this region. Recent studies documented positive trends in gross primary productivity (GPP) for Arctic boreal biomes driven by warming, but it is unclear how GPP trends are affected by wildfires. Here, we used satell

Mortality among amphetamine users with hepatitis C virus infection : A nationwide study

Aims To investigate liver-related and all-cause mortality among amphetamine users with hepatitis C virus (HCV) infection and compare this with opioid users with HCV infection and the uninfected general population. Methods In this national register study of mortality in persons notified with HCV infection 1990–2015 and a substance-related diagnosis in Sweden, amphetamine users (n = 6,509) were comp

Validation of the Skåne University Hospital nomogram for the preoperative prediction of a disease-free axilla in patients with breast cancer

BACKGROUND: Axillary staging via sentinel lymph node biopsy (SLNB) is performed for clinically node-negative (N0) breast cancer patients. The Skåne University Hospital (SUS) nomogram was developed to assess the possibility of omitting SLNB for patients with a low risk of nodal metastasis. Area under the receiver operating characteristic curve (AUC) was 0.74. The aim was to validate the SUS nomogra